Carbon nanomaterials: a promising avenue in colorectal cancer treatment

IF 5.5 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Carbon Letters Pub Date : 2024-09-23 DOI:10.1007/s42823-024-00805-2

Marzieh Ramezani Farani, Mandana Lak, William C. Cho, Haneul Kang, Maryam Azarian, Fatemeh Yazdian, Sharareh Harirchi, Keyvan Khoshmaram, Iraj Alipourfard, Kiavash Hushmandi, Seung-Kyu Hwang, Yun Suk Huh

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Abstract

Colorectal cancer (CRC) poses a significant global public health challenge, accounting for 10% of newly diagnosed cancer cases and causing 9.4% of cancer-related deaths. Conventional treatment methods like surgery, chemotherapy, and radiation have shown limited success despite the increasing incidence of CRC. Thus, there is an urgent need for innovative therapeutic approaches. Researchers are continually working on developing novel technologies, notably focused on the creation of safe and effective cancer nanomedicines, in their continuous effort to advance cancer treatment. Nanoparticles exist at the nanoscale. Nanoparticles at the nanoscale have distinctive properties that leverage the metabolic disparities between cancerous and normal cells. This property allows them to selectively induce substantial cytotoxicity in cancer cells while minimizing damage to healthy tissue. Carbon nanomaterials (CNMs), including graphene oxide (GO), carbon nanotubes (CNTs), and nanodiamonds (NDs), have undergone extensive investigation due to their biocompatibility, surface-to-volume ratio, thermal conductivity, rigid structural properties, and ability for post-chemical modifications. Notably, GO has emerged as a promising two-dimensional (2D) material for cancer treatment. Several groundbreaking nanoparticle-based therapies, predominantly utilizing GO, are currently undergoing clinical trials, with some already gaining regulatory clearance.

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碳纳米材料：治疗结直肠癌的前景广阔的途径

结直肠癌（CRC）是全球公共卫生面临的重大挑战，占新诊断癌症病例的 10%，并导致 9.4% 的癌症相关死亡。尽管 CRC 的发病率不断上升，但手术、化疗和放疗等传统治疗方法的效果有限。因此，迫切需要创新的治疗方法。研究人员一直致力于开发新技术，特别是以创造安全有效的癌症纳米药物为重点，不断努力推进癌症治疗。纳米粒子存在于纳米尺度。纳米级的纳米粒子具有独特的特性，可以利用癌细胞和正常细胞之间的代谢差异。这种特性使它们能够选择性地诱导癌细胞产生大量细胞毒性，同时最大限度地减少对健康组织的损害。碳纳米材料（CNMs），包括氧化石墨烯（GO）、碳纳米管（CNTs）和纳米金刚石（NDs），因其生物相容性、表面体积比、导热性、刚性结构特性和化学后修饰能力而受到广泛研究。值得注意的是，GO 已成为治疗癌症的一种前景广阔的二维（2D）材料。目前，几种开创性的基于纳米粒子的疗法正在进行临床试验，其中一些已经获得了监管部门的批准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carbon Letters CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

7.30

自引率

20.00%

发文量

118

期刊介绍： Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.