Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis

IF 29.5 1区 医学 Q1 HEMATOLOGY Journal of Hematology & Oncology Pub Date : 2024-10-12 DOI:10.1186/s13045-024-01615-9
Lianxuan Liu, Mi Shao, Yue Huang, Pengxu Qian, He Huang
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Abstract

Due to spatial and genomic independence, mitochondria possess a translational mechanism distinct from that of cytoplasmic translation. Several regulators participate in the modulation of mitochondrial translation. Mitochondrial translation is coordinated with cytoplasmic translation through stress responses. Importantly, the inhibition of mitochondrial translation leads to the inhibition of cytoplasmic translation and metabolic disruption. Therefore, defects in mitochondrial translation are closely related to the functions of hematopoietic cells and various immune cells. Finally, the inhibition of mitochondrial translation is a potential therapeutic target for treating multiple hematologic malignancies. Collectively, more in-depth insights into mitochondrial translation not only facilitate our understanding of its functions in hematopoiesis, but also provide a basis for the discovery of new treatments for hematological malignancies and the modulation of immune cell function.
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揭示线粒体翻译在正常和恶性造血过程中的作用和机制
由于空间和基因组的独立性,线粒体具有不同于细胞质翻译的翻译机制。有几种调节因子参与线粒体翻译的调节。通过应激反应,线粒体翻译与细胞质翻译相互协调。重要的是,抑制线粒体翻译会导致抑制细胞质翻译和新陈代谢紊乱。因此,线粒体翻译缺陷与造血细胞和各种免疫细胞的功能密切相关。最后,抑制线粒体翻译是治疗多种血液恶性肿瘤的潜在治疗靶点。总之,对线粒体翻译的深入研究不仅有助于我们了解线粒体在造血过程中的功能,还为发现治疗血液恶性肿瘤和调节免疫细胞功能的新疗法提供了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
48.10
自引率
2.10%
发文量
169
审稿时长
6-12 weeks
期刊介绍: The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts. Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.
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