Progress of smart material in the repair of intervertebral disc degeneration

Q1 Engineering Smart Materials in Medicine Pub Date : 2024-10-09 DOI:10.1016/j.smaim.2024.10.001

Yisi Liu , Jie Hu , Hao Jiang , Hui He , Liwei Yao , Qianglong Chen , Lijie Wang , Ting Liang , Bin Li , Fengxuan Han

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Abstract

Intervertebral disc degeneration (IVDD) is a prevalent condition leading to back and leg pain as well as chronic disability. It refers to the degeneration of intervertebral disc structure, including the nucleus pulposus, annulus fibrosus, and cartilage endplate. Along with degeneration process, these components can deteriorate, causing pain and functional impairment. To address IVDD, researchers are exploring the use of smart materials as novel therapeutic approaches. This review aims to summarize the application of various stimuli-responsive smart materials (endogenous and exogenous stimuli-responsive materials) in the repair for Intervertebral disc. These smart materials, such as responsive hydrogels, shape-memory polymers, and nanoparticle-based delivery systems, have shown considerable potential in achieving targeted drug delivery and tissue regeneration, and improving clinical outcomes. The ongoing advancement of smart materials towards successful clinical translation holds promise for improving treatment outcomes for IVDD patients, providing more effective and safer therapeutic options.

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智能材料在修复椎间盘退变方面的进展

椎间盘退变（IVDD）是一种导致腰腿痛和慢性残疾的常见疾病。它是指椎间盘结构的退化，包括髓核、纤维环和软骨终板。伴随着退化过程，这些成分会恶化，导致疼痛和功能障碍。为解决 IVDD 问题，研究人员正在探索使用智能材料作为新型治疗方法。本综述旨在总结各种刺激响应智能材料（内源性和外源性刺激响应材料）在椎间盘修复中的应用。这些智能材料，如响应性水凝胶、形状记忆聚合物和基于纳米颗粒的递送系统，在实现定向药物递送和组织再生以及改善临床疗效方面已显示出相当大的潜力。智能材料在临床转化方面的不断进步为改善 IVDD 患者的治疗效果、提供更有效、更安全的治疗方案带来了希望。

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