Predicting the production of 51Mn as a useable radionuclide for PET imaging via the 52Cr(p,2n)51Mn reaction using GEANT4, MCNPX, TALYS, and EMPIRE codes

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL Radiation Physics and Chemistry Pub Date : 2025-01-01 Epub Date: 2024-09-26 DOI:10.1016/j.radphyschem.2024.112264

Farzad Isazadeh, Akbar Abdi Saray

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Abstract

⁵¹Mn is an ideal radioisotope for positron emission tomography (PET) in pancreatic imaging dues to its positron emission characteristics (E_β+ = 963.7 keV, I_β+ = 97%) and its advantageous short half-life (T_1/2 = 46.2 min). In this study, the production of ⁵¹Mn via the ⁵²Cr(p,2n)⁵¹Mn reaction was predicted by calculating cross-section and production yield parameters using GEANT4-10.7, MCNPX, TALYS-1.96, SRIM, and EMPIRE-3.2.3 nuclear codes. The GEANT4 and SRIM codes were applied to investigate range of protons in ⁵²Cr target. The cross-section of the ⁵²Cr(p,2n)⁵¹Mn reaction was determined by GEANT4, EMPIRE, and four methods of TALYS code. The thick yield of the reaction was evaluated via two different ways of GEANT4 toolkit, and also TALYS and MCNPX codes. At the end, the simulated values were compared to previous reported experimental data, which were in good compatibility to each other.

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使用 GEANT4、MCNPX、TALYS 和 EMPIRE 代码预测通过 52Cr(p,2n)51Mn 反应生成 51Mn 作为 PET 成像可用放射性核素的情况

51Mn 因其正电子发射特性（Eβ+ = 963.7 keV，Iβ+ = 97%）和短半衰期（T1/2 = 46.2 分钟）而成为胰腺正电子发射断层成像（PET）的理想放射性同位素。在这项研究中，通过使用 GEANT4-10.7、MCNPX、TALYS-1.96、SRIM 和 EMPIRE-3.2.3 核代码计算横截面和产率参数，预测了通过 52Cr(p,2n)51Mn 反应生成 51Mn。GEANT4 和 SRIM 代码用于研究 52Cr 靶内的质子范围。通过 GEANT4、EMPIRE 和 TALYS 代码的四种方法确定了 52Cr(p,2n)51Mn 反应的横截面。通过 GEANT4 工具包的两种不同方法以及 TALYS 和 MCNPX 代码评估了反应的浓产率。最后，将模拟值与之前报告的实验数据进行了比较，结果表明两者具有很好的兼容性。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.