Wu Yi-xun , Wang Xiao-wei , Wang Hai-bo , Qin Zi-Fei , Jia An , Wei Wen-jun , Guo Tao
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引用次数: 0
Abstract
Two unreported sesquiterpenoids, 7-en-13-hytanaphallin (1) and 8´-en-achillinin C (2) along with two known sesquiterpenoid dimers were obtained from chloroform parts in the leaves of Artemisia argyi Lévl. et Vant, belonging to Asteraceae family. The planar structures and absolute configurations of two new compounds were characterized by HR-ESI-MS, IR, 1D and 2D NMR, and electronic circular dichroism analyses. Two known sesquiterpenoids, argyinolide O (3) and (+)-8-acetylarteminolide (4), exhibited potent activities against NO production from LPS-induced RAW264.7 cells with IC50 values of 3.6 and 9.8 μM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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