Characterization of a real time dosimetry system using 2D nano and micro-coatings in proton and carbon therapeutic ion beams

IF 1.6 3区物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY Radiation Measurements Pub Date : 2024-09-27 DOI:10.1016/j.radmeas.2024.107303

Luana de Freitas Nascimento , Marijke De Saint-Hubert , Marco Caprioli , Laurence Delombaerde , Katleen Himschoot , Dirk Vandenbroucke , Paul Leblans , Wouter Crijns , Satoshi Kodaira

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Abstract

Real-time radioluminescence two-dimensional coatings have potential as dosemeters in proton and carbon therapeutic beams. We investigated coatings made of nano and micro-(C₄₄H₃₈P₂)MnCl₄ and (C₃₈H₃₆P₂)MnBr₄ crystals mixed with a water-equivalent substrate. The response of the radioluminescence signal of the coatings along the Bragg curves presented an ionization quenching effect, but less prominent than what has been observed in our previous works using Al₂O₃:X (X = C and C,Mg) coatings. We hypothesize that this results from their lower crystal sizes and effective atomic number (Z_eff). Combined experimental results and Monte Carlo simulations resulted in correction factors to address the linear energy transfer dependence and restore the constant response for particle therapy beams. The quenching correction method was applied to the studied proton and carbon ion beams and yielded the best results for the nano-(C₄₄H₃₈P₂)MnCl_4, coating, followed by the micro-(C₄₄H₃₈P₂)MnCl₄, nano-(C₃₈H₃₆P₂)MnBr₄, and micro-(C₃₈H₃₆P₂)MnBr₄.

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在质子和碳治疗离子束中使用二维纳米和微涂层的实时剂量测定系统的特性分析

实时放射发光二维涂层具有作为质子和碳治疗束剂量计的潜力。我们研究了由纳米和微米-(C44H38P2)氯化锰和(C38H36P2)溴化锰晶体与水等效基质混合制成的涂层。涂层的辐射发光信号沿布拉格曲线的响应呈现出电离淬灭效应，但没有我们之前使用 Al2O3:X（X = C 和 C,Mg）涂层时观察到的效应那么突出。我们推测这是由于它们的晶体尺寸和有效原子序数（Zeff）较低造成的。结合实验结果和蒙特卡洛模拟，我们得出了修正系数，以解决线性能量转移依赖性问题，并恢复粒子治疗光束的恒定响应。淬火修正法适用于所研究的质子和碳离子束，对纳米（C44H38P2）氯化锰涂层的效果最好，其次是微量（C44H38P2）氯化锰、纳米（C38H36P2）溴化锰和微量（C38H36P2）溴化锰。

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来源期刊

Radiation Measurements 工程技术-核科学技术

CiteScore

4.10

自引率

20.00%

发文量

116

审稿时长

48 days

期刊介绍： The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.