Vat photopolymerization of ultra-porous bioactive glass foams

IF 2.9 Q1 MATERIALS SCIENCE, CERAMICS Open Ceramics Pub Date : 2024-09-30 DOI:10.1016/j.oceram.2024.100690

Francesco Baino , Federico Gaido , Roberta Gabrieli , Dario Alidoost , Alessandro Schiavi , Mehdi Mohammadi , Martin Schwentenwein , Dilshat Tulyaganov , Enrica Verné

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Abstract

The introduction of additive manufacturing technologies in the field of biomaterials science has opened new horizons for regenerative medicine. In this work, we pushed the potential of vat polymerization to the limit for fabricating ultra-porous bioactive SiO₂-CaO-MgO-P₂O₅-CaF₂-Na₂O glass scaffolds with bone-like architectural characteristics. The tomographic reconstruction of an open-cell foam was used as input file to the printing system and reliably reproduced in all its exquisite details, as assessed by morphological analyses of sintered scaffolds (thickness of single struts 35 μm, exceptionally high porosity around 94 vol%, most pores with size from 500 to 900 μm). Immersion studies in simulated body fluid (SBF) revealed the apatite-forming ability (i.e., in vitro bioactivity) of the scaffolds, the surface of which started being coated by calcium phosphate after just 3 days from the beginning of the experiments. Taken together, these results show great promise for application of such scaffolds in bone defect repair.

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超多孔生物活性玻璃泡沫的釜式光聚合反应

在生物材料科学领域引入增材制造技术为再生医学开辟了新天地。在这项工作中，我们将大桶聚合的潜力发挥到了极致，制造出了具有类骨结构特征的超多孔生物活性 SiO2-CaO-MgO-P2O5-CaF2-Na2O 玻璃支架。开孔泡沫的层析重建被用作打印系统的输入文件，并通过烧结支架的形态分析（单个支柱的厚度为 35 μm，孔隙率极高，约为 94%，大多数孔的大小为 500 至 900 μm）可靠地再现了其所有精致的细节。在模拟体液（SBF）中进行的浸泡研究显示了支架的磷灰石形成能力（即体外生物活性），从实验开始到现在，仅用了 3 天时间，支架表面就开始被磷酸钙包覆。综上所述，这些结果表明这种支架在骨缺损修复中的应用前景广阔。

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