LIPOPROTEIN(A) AND CARDIOVASCULAR RISK. A RETROSPECTIVE COHORT STUDY FROM NYC/HHC+ PUBLIC HOSPITAL IN NEW YORK CITY

IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS American journal of preventive cardiology Pub Date : 2024-09-01 DOI:10.1016/j.ajpc.2024.100759

Natalia Nazarenko MD

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Abstract

Therapeutic Area

ASCVD/CVD Risk Factors

Background

Lipoprotein(a) [Lp(a)] is a independent genetic risk factor for cardiovascular disease with heritability rates ranging from 70% to 90%. Our study aimed to compare demographic and clinical characteristics in patients with normal vs. abnormal Lp(a).

Methods

We conducted a retrospective chart review at Jacobi Medical Center from August 2020 to September 2023 and we identified 78 patients with available Lp(a) measurement.

Results

Among 78 patients, 32 (41.03%) were female, and 46 (58.97%) were male. 32 patients had abnormal Lp(a) (>75 nmol/L) with a mean of 143.35 nmol/L, mean BMI of 30.34 and median age of 53.5 years. Abnormal Lp(a) correlated with higher LDL levels (111.01 vs. 91.23 mg/dL; p=0.044). Increased Lp(a) was more prevalent among African Americans. No significant association was found between abnormal Lp(a) and aortic or mitral valve calcifications. In the cohort with abnormal Lp(a) levels, the prevalence of heart failure with preserved ejection fraction (HFpEF) was 100%, while the presence of heart failure with reduced ejection was notably lower at 24% (p=0.008). The demographic and clinical characteristics are presented in Table 1.

Conclusions

Our study found no significant difference in comorbidities between both groups but did show a correlation with elevated LDL. HFpEF was more prevalent among patients with abnormal Lp(a).

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脂蛋白（a）与心血管风险。一项来自纽约市 NYC/hhc+ 公立医院的回顾性队列研究

治疗领域心血管疾病/心血管疾病风险因素背景脂蛋白（a）[Lp（a）]是心血管疾病的独立遗传风险因素，其遗传率为 70% 至 90%。我们的研究旨在比较脂蛋白（a）正常与脂蛋白（a）异常患者的人口统计学特征和临床特征。方法我们对雅各比医疗中心 2020 年 8 月至 2023 年 9 月期间的病历进行了回顾性分析，并确定了 78 名可进行脂蛋白（a）测量的患者。32 名患者的脂蛋白（a）异常（75 nmol/L），平均值为 143.35 nmol/L，平均体重指数（BMI）为 30.34，中位年龄为 53.5 岁。脂蛋白（a）异常与较高的低密度脂蛋白水平相关（111.01 vs. 91.23 mg/dL；p=0.044）。非裔美国人的脂蛋白（a）增高更为普遍。在 Lp(a) 异常与主动脉瓣或二尖瓣钙化之间没有发现明显的关联。在脂蛋白（a）水平异常的人群中，射血分数保留型心力衰竭（HFpEF）的发病率为 100%，而射血分数降低型心力衰竭的发病率明显较低，仅为 24%（P=0.008）。两组患者的人口统计学和临床特征见表 1。在脂蛋白（a）异常的患者中，HFpEF 的发病率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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