Soft hydrogels obtained by photothermal curing of poly(vinylpyrrolidone)/gold nanoparticles dispersions showing anisotropic swelling and photo-activated antimicrobial properties

IF 5.8 2区 化学 Q1 POLYMER SCIENCE European Polymer Journal Pub Date : 2024-10-09 DOI:10.1016/j.eurpolymj.2024.113491
Ana C. Scanone , María E. Pérez , Pablo A. Vallina , Edgardo N. Durantini , Gustavo F. Arenas , Cristina E. Hoppe
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Abstract

Poly(vinylpyrrolidone) (PVP) hydrogels were obtained by green light irradiation of aqueous PVP/ammonium persulfate solutions modified with gold nanoparticles (AuNPs). The increase in temperature produced through the activation of the photothermal effect of AuNPs triggers the decomposition of ammonium persulfate producing radicals that, by attacking the polymer main chain and generating macro-radicals, induce the crosslinking of the polymer via recombination paths. Irradiation from the top of the solutions in an open configuration produced water evaporation and a concomitant increase in temperature during curing, giving rise to dry materials with high aspect ratio and moderate swelling anisotropy. Pads that reversibly adhere to different substrates, including human skin, were produced by simple contact of the final materials with water. Impregnation of gauze wound dressings with PVP-Au-ammonium persulfate dispersions, followed by direct “in situ” photothermal crosslinking, enabled the fabrication of supported functional pads with potential applications as reversible adhesive skin wound dressings. Infusion of the hydrogels with Rose Bengal (RB) provides the materials with photosensitizing properties useful for the photodynamic inactivation of Staphylococcus aureus. A decrease in cell viability of 99.9% was attained after 30 min of irradiation with a low-power green LED source, which demonstrates the efficient singlet oxygen production by RB in the hydrogels and paves the way towards the design of new stimulus-activated bactericidal supplies for biomedical uses.

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通过光热固化聚(乙烯基吡咯烷酮)/金纳米粒子分散体获得的软水凝胶具有各向异性溶胀和光活化抗菌特性
通过绿光照射用金纳米粒子(AuNPs)修饰的聚乙烯吡咯烷酮(PVP)/过硫酸铵水溶液,获得了聚乙烯吡咯烷酮(PVP)水凝胶。通过激活 AuNPs 的光热效应产生的温度升高引发了过硫酸铵的分解,产生自由基,通过攻击聚合物主链和产生大自由基,诱导聚合物通过重组途径发生交联。在固化过程中,从开放结构的溶液顶部进行辐照会导致水分蒸发和温度随之升高,从而产生具有高纵横比和适度膨胀各向异性的干燥材料。只需将最终材料与水接触,就能制成可逆性粘附在不同基底(包括人体皮肤)上的垫子。用 PVP-Au- 过硫酸铵分散体浸渍纱布伤口敷料,然后直接进行 "原位 "光热交联,就能制造出具有可逆粘附皮肤伤口敷料应用潜力的支撑功能垫。用玫瑰红(RB)灌注水凝胶可使材料具有光敏特性,有助于光动力灭活金黄色葡萄球菌。用低功率绿色 LED 光源照射 30 分钟后,细胞存活率降低了 99.9%,这表明水凝胶中的玫瑰红能高效产生单线态氧,为设计用于生物医学用途的新型刺激活化杀菌用品铺平了道路。
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来源期刊
European Polymer Journal
European Polymer Journal 化学-高分子科学
CiteScore
9.90
自引率
10.00%
发文量
691
审稿时长
23 days
期刊介绍: European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.
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