{"title":"Comparative Monte Carlo simulation study of helium-induced DNA damage versus proton","authors":"Renjun Jin, Jie Ma, Hao Shen, Zhaohong Mi","doi":"10.1016/j.nimb.2024.165538","DOIUrl":null,"url":null,"abstract":"<div><div>Helium ions are thought to be effective for radiotherapy, and characterization of physical quantities related to cellular effects of helium ions are important in order to develop and improve treatment planning systems for helium ions. In this study, Geant4-DNA was used to obtain the physical energy deposit and OH reaction sites to feed the density-based spatial clustering of applications with noise (DBSCAN) and obtain the quantities related with DNA strand breaks. The results are compared to other calculations and show that with proper choice of variables, DBSCAN could be used to calculate the DNA damage. The helium DSB (double strand break) yields with chemical processes increased from 11.48 <span><math><mrow><msup><mrow><mo>(</mo><mi>G</mi><mi>y</mi><mi>G</mi><mi>b</mi><mi>p</mi><mo>)</mo></mrow><mrow><mo>-</mo><mn>1</mn></mrow></msup></mrow></math></span> with the LET of 56.3 keV/μm to 49.32 <span><math><mrow><msup><mrow><mo>(</mo><mi>G</mi><mi>y</mi><mi>G</mi><mi>b</mi><mi>p</mi><mo>)</mo></mrow><mrow><mo>-</mo><mn>1</mn></mrow></msup></mrow></math></span> at 219.2 keV/μm. The helium SSB (single strand break) yields with chemical processes decreased from 255.36 <span><math><mrow><msup><mrow><mo>(</mo><mi>G</mi><mi>y</mi><mi>G</mi><mi>b</mi><mi>p</mi><mo>)</mo></mrow><mrow><mo>-</mo><mn>1</mn></mrow></msup></mrow></math></span> with the LET of 56.3 keV/μm to 161.28 <span><math><mrow><msup><mrow><mo>(</mo><mi>G</mi><mi>y</mi><mi>G</mi><mi>b</mi><mi>p</mi><mo>)</mo></mrow><mrow><mo>-</mo><mn>1</mn></mrow></msup></mrow></math></span> at 219.2 keV/μm. SSB and DSB counts induced by helium particles incident on the lung adenocarcinoma cell nucleus increased by about 90 % and 200 % compared with those without chemical processes.</div></div>","PeriodicalId":19380,"journal":{"name":"Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms","volume":"557 ","pages":"Article 165538"},"PeriodicalIF":1.4000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168583X24003082","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
引用次数: 0
Abstract
Helium ions are thought to be effective for radiotherapy, and characterization of physical quantities related to cellular effects of helium ions are important in order to develop and improve treatment planning systems for helium ions. In this study, Geant4-DNA was used to obtain the physical energy deposit and OH reaction sites to feed the density-based spatial clustering of applications with noise (DBSCAN) and obtain the quantities related with DNA strand breaks. The results are compared to other calculations and show that with proper choice of variables, DBSCAN could be used to calculate the DNA damage. The helium DSB (double strand break) yields with chemical processes increased from 11.48 with the LET of 56.3 keV/μm to 49.32 at 219.2 keV/μm. The helium SSB (single strand break) yields with chemical processes decreased from 255.36 with the LET of 56.3 keV/μm to 161.28 at 219.2 keV/μm. SSB and DSB counts induced by helium particles incident on the lung adenocarcinoma cell nucleus increased by about 90 % and 200 % compared with those without chemical processes.
期刊介绍:
Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.