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{"title":"Carcinomes neuroendocrines à grandes cellules (CNEGC) : actualités 2024","authors":"E. Gaye , A. Jannin , C. Do Cao , E. Dansin","doi":"10.1016/S1877-1203(24)00095-8","DOIUrl":null,"url":null,"abstract":"<div><div>Large cell neuroendocrine carcinomas (LCNECs) are rare tumors with high grade malignancy and poor prognosis. The management of LCNECs remains complex and several clinical situations (induction, metastatic stages, etc.) are still debating. While the impact of molecular profiling of these tumors on optimal systemic treatment choice has yet to be demonstrated, the prospective evaluation of immunotherapy in metastatic stages is ongoing and could open up new therapeutic options.</div><div>1877-1203/© 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved.</div></div>","PeriodicalId":53645,"journal":{"name":"Revue des Maladies Respiratoires Actualites","volume":"16 2","pages":"Pages 2S250-2S254"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue des Maladies Respiratoires Actualites","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1877120324000958","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Large cell neuroendocrine carcinomas (LCNECs) are rare tumors with high grade malignancy and poor prognosis. The management of LCNECs remains complex and several clinical situations (induction, metastatic stages, etc.) are still debating. While the impact of molecular profiling of these tumors on optimal systemic treatment choice has yet to be demonstrated, the prospective evaluation of immunotherapy in metastatic stages is ongoing and could open up new therapeutic options.
1877-1203/© 2024 SPLF. Published by Elsevier Masson SAS. All rights reserved.
大细胞神经内分泌癌(LCNEC):2024 年新闻
大细胞神经内分泌癌(LCNECs)是一种罕见的恶性程度高、预后差的肿瘤。LCNECs 的治疗仍然很复杂,一些临床情况(诱导、转移阶段等)仍在争论之中。虽然这些肿瘤的分子图谱分析对最佳系统治疗选择的影响尚未得到证实,但对转移期免疫疗法的前瞻性评估正在进行中,并可能开辟新的治疗方案。由 Elsevier Masson SAS 出版。保留所有权利。
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