{"title":"Fluorescence detection setups in capillary electrophoresis and microscale liquid chromatography: Developments over the past decade","authors":"","doi":"10.1016/j.trac.2024.118001","DOIUrl":null,"url":null,"abstract":"<div><div>Properly adjusted and operated fluorescence detectors may provide higher sensitivity than mass spectrometers and far better sensitivity and selectivity than absorbance detectors. Therefore, various fluorescence detectors are being continuously developed and adapted for high-performance liquid chromatography and capillary electrophoresis. This mini-review summarizes recent developments in fluorescence detectors applicable in capillary scale separation systems with emphasis on the technical details of the optical arrangements, excitation light sources, appearance of the detection zone, multi-wavelength detection schemes, and fluorescence monitoring in tandem with other detection principles. Microchip configurations are not covered.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993624004849","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Properly adjusted and operated fluorescence detectors may provide higher sensitivity than mass spectrometers and far better sensitivity and selectivity than absorbance detectors. Therefore, various fluorescence detectors are being continuously developed and adapted for high-performance liquid chromatography and capillary electrophoresis. This mini-review summarizes recent developments in fluorescence detectors applicable in capillary scale separation systems with emphasis on the technical details of the optical arrangements, excitation light sources, appearance of the detection zone, multi-wavelength detection schemes, and fluorescence monitoring in tandem with other detection principles. Microchip configurations are not covered.
期刊介绍：
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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