Degradation of Mesoporous Silica Materials in Biological Milieu: The Gateway for Therapeutic Applications

IF 4 Q2 ENGINEERING, BIOMEDICAL Advanced Nanobiomed Research Pub Date : 2024-09-02 DOI:10.1002/anbr.202400005
Sergio E. Moya, Raquel Ruiz Hernández, Paula C. Angelomé
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Abstract

Since early developments in the field of mesoporous materials, mesoporous silica has attracted large interest in drug delivery, as they display an ordered array of pores with diameters ranging from 2 to 50 nm, which can be loaded with drugs. Mesoporous silica dissolves at physiological pH, triggering the release of loaded drugs. Several studies have focused on determining the key factors that determine the biodistribution, biocompatibility, and toxicity both in vitro or in vivo. However, in vivo studies focused on the degradation of mesoporous silica materials are very scarce, despite its relevance for drug release. In this perspective, recent works addressing mesoporous materials degradation in the context of drug delivery are discussed, first from a physicochemical point of view, and secondly in in vivo settings, in animal models that are the closest conditions to the encountered when the mesoporous materials are administered to humans. Finally, further discussion about the future directions in the design of mesoporous nanomaterials for therapy and for the study of their biological fate are presented.

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介孔二氧化硅材料在生物环境中的降解:治疗应用之门
自介孔材料领域的早期发展以来,介孔二氧化硅在药物递送方面引起了广泛的兴趣,因为介孔二氧化硅显示出直径从 2 纳米到 50 纳米不等的有序孔阵列,可以负载药物。介孔二氧化硅在生理 pH 值下会溶解,从而引发药物的释放。一些研究侧重于确定决定体外或体内生物分布、生物相容性和毒性的关键因素。然而,尽管介孔二氧化硅材料与药物释放密切相关,但有关介孔二氧化硅材料降解的体内研究却很少。从这个角度出发,我们讨论了近期针对介孔材料在给药过程中降解的研究,首先从物理化学的角度,其次从体内环境的角度,即在动物模型中,讨论了介孔材料在给人类给药过程中的降解问题。最后,进一步讨论了介孔纳米材料治疗设计及其生物转归研究的未来方向。
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来源期刊
Advanced Nanobiomed Research
Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-
CiteScore
5.00
自引率
5.90%
发文量
87
审稿时长
21 weeks
期刊介绍: Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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