Balancing inflammation and adverse effects of glucocorticoids in clinical practice

Q3 Health Professions Revista Colombiana de Reumatologia Pub Date : 2024-10-01 DOI:10.1016/j.rcreu.2023.08.004

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Abstract

Corticosteroids play a vital role in enabling the body to tolerate stressful situations and regulate the inflammatory process. Excessive or persistent inflammation can lead to tissue damage and the development of diseases. Glucocorticoids are crucial in modulating the impact of inflammatory disorders, such as allergies, autoimmune diseases, and sepsis. These disorders can be life-threatening and benefit from glucocorticoid administration. Natural and synthetic glucocorticoids are utilized for the diagnosis and treatment of adrenal function disorders and various inflammatory, immune, and neoplastic conditions. The discovery of glucocorticoids is a testament to the ingenuity and collaboration of researchers. For over 70 years, glucocorticoids have revolutionized medicine and are widely employed in various medical conditions. This article provides a comprehensive review of the critical considerations for the clinical application of glucocorticoids, aiming to strike a balance between their benefits and potential risks. Understanding its history, chemical structure, pharmacology, and mechanisms of action provides the foundation for achieving proper use of this type of medication.

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在临床实践中平衡炎症和糖皮质激素的不良反应

皮质类固醇在帮助人体承受压力和调节炎症过程方面发挥着重要作用。过度或持续的炎症可导致组织损伤和疾病的发生。糖皮质激素对调节过敏、自身免疫性疾病和败血症等炎症性疾病的影响至关重要。这些疾病可能会危及生命，而服用糖皮质激素则可使其获益。天然和合成的糖皮质激素可用于诊断和治疗肾上腺功能紊乱以及各种炎症、免疫和肿瘤疾病。糖皮质激素的发现证明了研究人员的智慧和合作。70 多年来，糖皮质激素给医学带来了革命性的变化，并被广泛应用于各种病症。本文全面回顾了糖皮质激素临床应用的关键注意事项，旨在平衡其益处和潜在风险。了解糖皮质激素的历史、化学结构、药理学和作用机制为正确使用此类药物奠定了基础。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

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0.00%

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期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.