Dietary fibre and metabolic health: A clinical primer

IF 7.9 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Translational Medicine Pub Date : 2024-10-13 DOI:10.1002/ctm2.70018

Valentin Mocanu, Karen L Madsen

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Abstract

Dietary fibres consist of a heterogeneous group of carbohydrate polymers which resist digestion by human gastrointestinal enzymes. Consumption of dietary fibre has been linked with innumerable health benefits encompassing the foundational pillars of metabolic health from obesity to hypertension, dyslipidaemia, and type 2 diabetes mellitus (T2DM), with many of these benefits linked with metabolites produced by the fermentation of fibre by gut microbes [1]. The potential of dietary fibre to provide a safe and effective nonpharmacologic complementary tool with which to combat the evolving consequences of the obesity epidemic has recently garnered tremendous attention in both medical literature and lay media alike.

Highlights

Consumption of dietary fibre has been linked with innumerable health benefits encompassing the foundational pillars of metabolic health with many of these benefits linked with metabolites produced by the fermentation of fibre by gut microbes
At the present time clinicians are faced with an impossible task in which there is rapidly mounting evidence for dietary fibres advancing metabolic health, but little practical options for healthcare providers other than to simply recommend patients consume more fibre.
Benefits of fibre intake may perhaps be maximised in an individual by matching specific fibre consumption with existing microbial functional characteristics
If dietary fibres could be demonstrated to act as successful adjuncts to sustain or improve standard of care therapies or even alleviate common gastrointestinal side effects associated with current treatments, they would be an invaluable tool in our metabolic health armamentarium. Neither Dr. Madsen or I have any financial conflicts of interest pertinent to the contents of this manuscript.

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膳食纤维与代谢健康：临床入门

膳食纤维由一组不同的碳水化合物聚合物组成，这些聚合物能够抵抗人体胃肠道酶的消化作用。食用膳食纤维对健康的益处数不胜数，涵盖了从肥胖到高血压、血脂异常和 2 型糖尿病（T2DM）等代谢健康的基本支柱，其中许多益处与肠道微生物发酵纤维产生的代谢物有关 [1]。最近，膳食纤维作为一种安全有效的非药物补充工具，在应对肥胖症不断演变的后果方面所具有的潜力引起了医学文献和非专业媒体的极大关注。要点摄入膳食纤维对健康的益处数不胜数，涵盖了代谢健康的基本支柱，其中许多益处与肠道微生物发酵纤维产生的代谢物有关。目前，临床医生面临着一项不可能完成的任务，即有越来越多的证据表明膳食纤维能促进代谢健康，但医疗服务提供者除了简单地建议病人摄入更多纤维外，几乎没有其他实际选择。如果能证明膳食纤维能成功地辅助维持或改善标准疗法，甚至减轻与当前疗法相关的常见胃肠道副作用，那么它们将成为我们代谢健康武器库中的宝贵工具。马德森博士和我本人都没有与本手稿内容相关的经济利益冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.