Photovoltaic Molecule-Based Phototheranostics With A-D-A Structure for Near-Infrared Fluorescence Imaging-Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL Luminescence Pub Date : 2024-10-14 DOI:10.1002/bio.4930

Liang Chen, Jierou Huang, Ming Tong, Xinchun He, Li Liu, Haiou Chen, Jianing Yi

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Abstract

Phototheranostics with near-infrared fluorescence and reactive oxygen species generation ability and high photothermal conversion efficiency (PCE) plays a significant role in fluorescence imaging-guided synergetic photodynamic and photothermal therapy of tumors. Here, a star molecule in organic photovoltaic materials, NCBDT-4C with an A-D-A conjugated structure, was assembled with DSPE-PEG-NH₂ to prepare water dispersive nanoparticles (NPs). The prepared NCBDT-4Cl NPs exhibited a maximum NIR absorption peak at 764 nm and a maximum fluorescence peak at 798 nm. These NPs could generate superoxide anion, singlet oxygen (¹O₂), and heat under 808 nm laser irradiation. The ¹O₂ generation quantum yield and PCE of the NPs were 37.5% and 53.6%, respectively. The combination of photodynamic and photothermal therapy of cancer was demonstrated in vitro and in vivo. This work presents the advanced application of organic photovoltaic materials in cancer phototherapy.

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具有 A-D-A 结构的基于光电分子的光otheranostics，用于近红外荧光成像引导的肿瘤光动力和光热协同治疗

具有近红外荧光和活性氧生成能力以及高光热转换效率（PCE）的光热蓄热技术在荧光成像引导的肿瘤光动力和光热疗法协同中发挥着重要作用。本文将有机光电材料中的明星分子--具有A-D-A共轭结构的NCBDT-4C与DSPE-PEG-NH2组装，制备出水分散纳米粒子（NPs）。制备的 NCBDT-4Cl NPs 在 764 纳米波长处显示出最大近红外吸收峰，在 798 纳米波长处显示出最大荧光峰。在 808 纳米激光照射下，这些 NPs 能产生超氧阴离子、单线态氧（1O2）和热量。这些 NPs 产生 1O2 的量子产率和 PCE 分别为 37.5% 和 53.6%。在体外和体内证实了光动力和光热疗法对癌症的联合治疗效果。这项工作展示了有机光伏材料在癌症光疗中的先进应用。

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.