Luminescence最新文献

Four benzothiazole-thiazolidine-4-one derivatives 6 and 7a–c were prepared, and their chemical constructions were proved by IR, NMR, UV–Vis absorption, and emission spectra. The absorption spectra of the synthesized derivatives showed that extending the conjugated system through the insertion of a substituted benzylidene group led to a red shift of λ_max, where the nitro derivative 7c displayed the longer wavelength. Likewise, the emission spectra presented the same effect, where the Stock shift displayed a reversed order in which the parent 6 has the highest value. The synthesized derivatives exhibited cytotoxic effectiveness against several tumor cell lines, where compound 7b displayed significant cytotoxicity towards MCF-7 cells (IC₅₀ = 8.73 ± 0.41 μM). The in vitro VEGFR-2 kinase inhibitory activity of synthetic benzothiazole-thiazolidin-4-one derivatives has been assessed, where derivative 7c had the strongest inhibition (IC₅₀ = 0.20 ± 0.10 μM), followed by derivatives 7b and 7a, respectively. However, the molecular docking showed that derivatives 7b and 7c have higher binding affinity than Sorafenib due to unique molecular interactions with target residues. Moreover, the pharmacokinetic parameters of the newly synthesized derivatives showed that derivative 7b revealed moderate lipophilicity and a lack of Lipinski violations, making it a viable lead contender.

The development of multifunctional biomaterials holds paramount importance in advancing biomedical research and applications. This investigation focuses on synthesizing cerium/reduced graphene oxide (Ce/RGO) nanocomposites using a hydrothermal approach. Structural evaluations via XRD and Raman spectroscopy confirm the successful conversion of graphene oxide (GO) to rGO and the integration of cerium nanoparticles onto the rGO surface. FTIR spectroscopy further validates structural alterations and the successful adhesion of cerium nanoparticles. Morphological and elemental analyses performed using FE-SEM and EDAX demonstrate the attachment of cerium nanoparticles onto rGO sheets. Enhanced hardness in Ce/rGO samples, compared with pure rGO, as indicated by Vickers hardness testing, suggests improved mechanical properties because of the existence of cerium nanoparticles. Measurements of the water contact angle show reduced hydrophobicity in Ce-rGO samples, implying enhanced wettability upon cerium nanoparticle integration. Additionally, porosity analysis reveals increased porosity in Ce/rGO samples, facilitating enhanced nutrient transfer within the system. Biocompatibility assessments, including hemolytic activity testing and Vero cell viability tests demonstrate favorable biocompatibility and improved cell viability in Ce/rGO samples compared with pure rGO. Antibacterial studies unveil increased efficacy against S. aureus and E. coli in Ce/rGO samples, attributed to the synergistic effects of rGO's antimicrobial properties and cerium nanoparticles' activity. This study highlights the encouraging potential of Ce/rGO nanostructures for biomedical applications, offering distinct mechanical properties, hydrophilicity, favorable biological interactions, and enhanced antibacterial performance.

In this study, a coumarin-based Schiff base (1) was designed and synthesized as a Zn²⁺-selective fluorescent chemosensor based on the PET mechanism. The structure of compound 1 was characterized by ¹H NMR and ¹³C NMR. The fluorescence properties of this chemosensor toward various metal ions were explored by fluorescence and UV–vis spectra. The results indicated that the chemosensor had high selectivity toward Zn²⁺ over other coexisting metal ions. The binding stoichiometry of 1 toward Zn²⁺ was determined to be 1:1 by Job's plot. Furthermore, the chemosensor was reversible for Zn²⁺ in an ethanol/H₂O (7:3, V/V) solution by the addition of Na₂ EDTA. The above experimental results demonstrate that 1 can be used as a fluorescent chemosensor for the real-time detection of Zn²⁺ in biological species and environmental systems.

Trace elements in environmental matrices and their potential harm to humans and the ecosystem are causing growing concern. For environmental monitoring and assessment, trace element analysis in water, soil, and air must be precise. Due to its selectivity and sensitivity, fluorometric analysis has grown in popularity. This review covers the latest fluorometric approaches for trace element measurement in environmental samples. This review discusses sensitive and selective fluorometric probes. A significant increase in fluorescence intensity makes this probe better for trace element research. Various parameters like pH, temperature, and reaction time were carefully optimized in each approach to increase sensitivity and accuracy. The current study sheds light on this analytical approach's concepts, applications, and difficulties. In general, fluorometric analysis is important for environmental studies. For researchers, it allows them to use fluorometric technology with other methods and focus on real-time analysis to solve environmental challenges.

Indigofera aspalathoides is a medicinal plant with significant traditional importance, known for its anti-inflammatory, antimicrobial, and hepatoprotective properties. In this study, the green synthesis of selenium nanoparticles (SeNPs) was performed using I. aspalathoides ethanolic extract and characterized through Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), x-ray diffraction (XRD), and dynamic light scattering (DLS) analytical techniques. The synthesized SeNPs were evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging assays, cytotoxicity using the MTT assay against the MCF-7 breast cancer cell line, and hepatoprotective potential against the HepG2 liver cancer cell line. Characterization confirmed that the SeNPs possessed a stable, spherical structure with an optimal size range of 50–80 nm, enhancing their bioavailability and biological interactions. The SeNPs demonstrated remarkable antioxidant activity, achieving 70.32% DPPH scavenging and 73.68% hydroxyl radical scavenging, significantly surpassing the activity of the plant extract alone. The hepatoprotective effects were dose dependent, with maximum protection of HepG2 liver cells observed at 88 μg/mL (100% viability), but higher concentrations (100 μg/mL) showed some cytotoxicity. These results underscore the potential of I. aspalathoides-derived SeNPs as innovative nanomedicine solutions for addressing oxidative stress, hepatic disorders, and infections.

The coupling of photocatalysis and piezocatalysis has gained significant interest among researchers. In this study, we present the photo-piezocatalytic activity exhibited by bismuth titanate (Bi₄Ti₃O₁₂) glass-ceramics (BTO-GC). BTO-GC samples were prepared in a glass system of 40Bi₂O₃-40B₂O₃-20TiO₂ (in mol %) by using the melt-quench technique. The catalyst was characterized by the X-ray diffraction (XRD) technique and Raman spectroscopy for its structure and phase analysis. Surface morphology and chemical composition were analyzed by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), respectively. The catalytic performance of BTO-GC was evaluated in photocatalysis, piezocatalysis, and photo-piezocatalysis processes. Methylene blue (MB) dye degradation was evaluated by using a UV–Vis spectrophotometer. A maximum degradation performance of ~86% was achieved in the solar light photocatalysis process. This study highlights the synergistic photo-piezocatalytic performance in glass-ceramics and advances the understanding of its underlying mechanism.

This study explores the green synthesis of copper nanoparticles (Cu-NPs) using Panchagavya, a traditional organic substance composed of five cow-derived components, as a reducing and stabilizing agent. Cu-NPs were characterized using UV–Vis, FT-IR, XRD, SEM-EDS, TEM, DLS, and zeta potential analysis, which revealed their size, shape, and elemental properties. They exhibited strong antibacterial activity against Bacillus cereus and Pseudomonas aeruginosa. Biofilm inhibition was observed at various concentrations, with 38.98% at ½ MIC, 67.48% at MIC, and 84.03% at 2× MIC. SEM analysis confirmed that Cu-NPs disrupted the bacterial cell membrane, causing leakage of cellular contents. Antioxidant assays (DPPH, FRAP) revealed high scavenging activity, with percentages of 88.50% and 92.54%, respectively. Cu-NPs showed anticancer activity on MCF7 cells, with an IC₅₀ of 38.18 μg/mL. Additionally, Cu-NPs significantly reduced nitric oxide (NO) production in RAW 264.7 macrophage cells in a dose-dependent manner. The Cu-NPs also exhibited larvicidal efficacy, with 99.12% mortality against Aedes aegypti and 95.26% against Culex quinquefasciatus, and LC₅₀ values of 29.40 μg/mL and 93.55 μg/mL, respectively. Morphological changes in treated larvae included body shrinkage and degeneration of tracheal tube and ventral brush were noticed as compared to control. Histopathological examinations of Cu-NP-treated larvae showed several structural damages, including damage to gut epithelial cells, dissipation of the muscle layer, and loss of goblet cells. GC–MS analysis of Panchagavya revealed its potential for various biological applications. These findings highlight the eco-friendly and multifunctional nature of Panchagavya-mediated Cu-NPs, demonstrating their potential for antimicrobial, antioxidant, anticancer, and larvicidal applications, which could contribute to sustainable pest and disease management strategies.