Urine Liquid Biopsies via Highly Integrated Digital PCR System for Accurate Detection of Bladder Cancer (Adv. Therap. 10/2024)

IF 3.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY Advanced Therapeutics Pub Date : 2024-10-13 DOI:10.1002/adtp.202470020
Yue Zhang, Ming Xu, Zhihong Wu, Fan Yang, Lu Zhang, Yiquan Liu, Jiahao Lv, Shuyue Xiang, Beiyuan Fan, Zijian Zhao, Yanzhao Li, Yang Yu
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Abstract

In article 2400191, Zijian Zhao, Yanzhao Li, Yang Yu, and co-workers develop a highly accurate urine-based diagnostic tool for bladder cancer using an on-chip heating dPCR system. By integrating genetic and epigenetic biomarkers and optimizing the diagnostic model with machine learning, the tool achieved high sensitivity and specificity in detecting bladder cancer and shows potential for differentiating tumor stages.

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通过高度集成的数字 PCR 系统进行尿液液体活检以准确检测膀胱癌(Adv. Therap.)
在第2400191号文章中,赵子健、李彦钊、于洋及其合作者利用片上加热dPCR系统开发了一种基于尿液的膀胱癌高精度诊断工具。通过整合遗传学和表观遗传学生物标记物并利用机器学习优化诊断模型,该工具在检测膀胱癌方面实现了高灵敏度和高特异性,并显示出区分肿瘤分期的潜力。
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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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