Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics

IF 26.6 1区材料科学 Q1 Engineering Nano-Micro Letters Pub Date : 2024-10-17 DOI:10.1007/s40820-024-01536-9

Shichang Liu, Farid Manshaii, Jinmiao Chen, Xinfei Wang, Shaolei Wang, Junyi Yin, Ming Yang, Xuxu Chen, Xinhua Yin, Yunlei Zhou

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Abstract

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration. Inspired by bioelectricity, electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix, thereby accelerating bone regeneration. With ongoing advances in biomaterials and energy-harvesting techniques, electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue. In this review, we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue. Next, we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering. Finally, we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

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释放骨治疗电活性混合生物材料和自供电系统的潜力

在全球范围内，由外伤造成的大面积骨缺损的发生率正在不断上升，由于自愈能力有限，组织再生过程需要较长的恢复时间。内源性生物电现象已被公认为骨重塑和再生过程中的关键生物物理因素。受生物电的启发，电刺激被广泛认为是一种外部干预措施，可诱导细胞的成骨系，促进细胞外基质的合成，从而加速骨再生。随着生物材料和能量收集技术的不断进步，电活性生物材料和自供电系统被认为是一种生物仿生方法，可通过重现健康骨组织的天然电生理微环境来确保功能恢复。在这篇综述中，我们首先介绍了生物电和内源性电场在骨组织中的作用，并总结了电刺激细胞和组织的不同技术。接下来，我们将重点介绍在探索电活性混合生物材料、自供电系统（如基于三电和压电的纳米发电机和基于光电池的设备）及其在骨组织工程中的应用方面取得的最新进展。最后，我们强调了模拟目标组织电生理微环境的重要性，并提出了电活性混合生物材料和自供电生物电子学在骨修复策略中面临的机遇和挑战。

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.