Antifungal, antibacterial and antioxidant activity of Pinus roxburghii mediated green synthesized zinc and gadolinium doped manganese oxide nanoparticles

Abstract

The exploration into the synthesis and characterization of manganese oxide nanoparticles (MO NPs) has garnered considerable attention, driven by their potential applications across various fields, particularly in medicine and biotechnology. This study focuses on investigating the diverse biological functions of Zinc doped (Zn)-MO and Gadolinium doped (Gd)-MO NPs, including their antifungal, antibacterial, and antioxidant properties. The NPs were synthesized using a sustainable green approach incorporating phytochemicals sourced from Pinus roxburghii. XRD confirmed tetragonal structure for both Zn-CuO and Gd-CuO NPs. Examination TEM and SEM-EDS revealed spheroidal NPs with diameters ranging from 8 to 12 nm. Evaluation of antifungal activity exhibited promising outcomes, indicating the capability of both Zn-MO and Gd-MO NPs to hinder fungal growth, suggesting their potential as antifungal agents. Similarly, the antibacterial effectiveness of these NPs was demonstrated by their ability to impede bacterial growth, highlighting their potential in addressing bacterial infections and potentially combating antibiotic resistance. Furthermore, the antioxidant activity of Zn-MO and Gd-MO NPs was assessed, revealing their capacity to scavenge free radicals and alleviate oxidative stress. In summary, the results emphasize the significant biological activities of Zn-MO and Gd-MO NPs, positioning them as promising candidates for further exploration and development in biomedical and pharmaceutical research.