A genome-wide association study reveals fetal genetic factor for gestation length on chromosome 21 in Japanese Black cattle

IF 1.7 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Science Journal Pub Date : 2024-10-15 DOI:10.1111/asj.14006
Marina Kurose-Iwanaga, Eiji Muraki, Shinji Sasaki
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Abstract

Gestation length (GL) in cattle is associated with neonatal health and the subsequent reproductive performance of dams. We performed a genome-wide association study (GWAS) using 25,144 single nucleotide polymorphisms (SNPs) in 4373 animals to detect genetic variants associated with GL as a fetal trait in Japanese Black cattle in Gifu Prefecture. We identified four significant SNPs on chromosome 21 in moderate linkage disequilibrium (LD). The minor allele of the most significant SNP has the effect on −2.47 days GL with a 0.019 allele frequency. Of the 4373 animals, 140 heterozygotes and one homozygote with the minor allele were traced back to a heterozygous sire. The 7.2 Mb LD region harbors three genes: gamma-aminobutyric acid type A receptor subunit beta3 (GABRB3), arrestin domain containing 4 (ARRDC4), and nuclear receptor subfamily 2 group F member 2 (NR2F2, also known as COUP-TFII). RNA expression analysis and its functions suggest that GABRB3, ARRDC4, and NR2F2 (COUP-TFII) are involved in glucose production via the hypothalamic–pituitary–adrenal axis during the fetal stress response at gestation period termination. These results suggest that an increase in the allele frequency of the associated SNPs has an impact on genetic improvement by shortening the GL in the population.

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全基因组关联研究揭示了日本黑牛 21 号染色体上妊娠期长短的胎儿遗传因子
牛的妊娠期(GL)与新生儿的健康和母牛随后的繁殖性能有关。我们在 4373 头牛中使用 25144 个单核苷酸多态性(SNPs)进行了全基因组关联研究(GWAS),以检测与岐阜县日本黑牛胎儿性状 GL 相关的遗传变异。我们在中度连锁不平衡(LD)的 21 号染色体上发现了四个重要的 SNPs。最显著 SNP 的小等位基因对 -2.47 天 GL 有影响,等位基因频率为 0.019。在 4373 头动物中,有 140 头杂合子和 1 头带有小等位基因的同源杂合子可追溯到杂合父本。7.2 Mb的LD区域包含三个基因:γ-氨基丁酸A型受体亚基β3(GABRB3)、含捕捉素结构域4(ARRDC4)和核受体亚家族2 F组2(NR2F2,又称COUP-TFII)。RNA 表达分析及其功能表明,GABRB3、ARRDC4 和 NR2F2(COUP-TFII)通过下丘脑-垂体-肾上腺轴参与妊娠期终止时胎儿应激反应过程中葡萄糖的产生。这些结果表明,相关 SNPs 等位基因频率的增加会缩短群体中的 GL,从而对遗传改良产生影响。
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来源期刊
Animal Science Journal
Animal Science Journal 生物-奶制品与动物科学
CiteScore
3.80
自引率
5.00%
发文量
111
审稿时长
1 months
期刊介绍: Animal Science Journal (a continuation of Animal Science and Technology) is the official journal of the Japanese Society of Animal Science (JSAS) and publishes Original Research Articles (full papers and rapid communications) in English in all fields of animal and poultry science: genetics and breeding, genetic engineering, reproduction, embryo manipulation, nutrition, feeds and feeding, physiology, anatomy, environment and behavior, animal products (milk, meat, eggs and their by-products) and their processing, and livestock economics. Animal Science Journal will invite Review Articles in consultations with Editors. Submission to the Journal is open to those who are interested in animal science.
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