Expression and role of methyltransferase 3 in oral malignant transformation

IF 2.5 4区生物学 Q1 ANATOMY & MORPHOLOGY Tissue & cell Pub Date : 2024-10-10 DOI:10.1016/j.tice.2024.102583

Tianyi Zhang , Haofeng Xiong , Liujun Zeng , Zhimin Yang , Xin Hu , Tong Su

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Abstract

Objective

To investigate the expression and role of methyltransferase 3 (METTL3) in oral malignant transformation.

Materials and methods

Immunohistochemical method was used to investigate the expression of METTL3 in the human oral malignant transformation. Bioinformatics analysis was used to explore the role of METTL3 in oral malignant transformation. Oral cancer animal model was used to verify the expression trend of METTL3 in oral malignant transformation. Knockdown of METTL3 expression in human oral mucosal precancerous lesion cells was performed to explore the METTL3 effect on proliferation, migration, apoptosis, and cell cycle.

Results

METTL3 expression was significantly up-regulated in the human oral malignant transformation. Moreover, METTL3 was related to the pathway of “Neuroactive ligand-receptor interaction.” In addition, METTL3 expression was also significantly up-regulated in the hamster oral malignant transformation. Finally, the proliferation and migration abilities of human oral mucosal precancerous lesion cells were inhibited after METTL3 knockdown.

Conclusions

In conclusion, we found that METTL3 was up-regulated in oral malignant transformation, and the role may relate to the pathway of “Neuroactive ligand-receptor interaction.”

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甲基转移酶 3 在口腔恶性转化中的表达和作用

材料与方法采用免疫组织化学方法研究METTL3在人类口腔恶性转化中的表达。采用生物信息学分析探讨 METTL3 在口腔恶性转化中的作用。利用口腔癌动物模型验证 METTL3 在口腔恶性转化中的表达趋势。结果METTL3在人类口腔恶性转化中表达显著上调。此外，METTL3与 "神经活性配体-受体相互作用 "途径有关。此外，在仓鼠口腔恶性转化中，METTL3 的表达也明显上调。结论我们发现，METTL3在口腔恶性转化中上调，其作用可能与 "神经活性配体-受体相互作用 "途径有关。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.