Diagnostic challenge: Combination of magnetic resonance imaging and serum soluble Interleukin-2 receptor in soft tissue non-hodgkin lymphoma

IF 1.5 Q3 ORTHOPEDICS Journal of orthopaedics Pub Date : 2024-10-10 DOI:10.1016/j.jor.2024.10.019

Takuya Watanabe , Tomoaki Torigoe , Yasuo Yazawa , Ken Nakazawa , Jungo Imanishi

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Abstract

Purpose

Non-Hodgkin lymphoma (NHL) sometimes occurs in soft tissue (referred to as soft tissue lymphoma or soft tissue NHL), often mimicking soft tissue tumors. Despite some clinical indicators, accurate diagnosis of soft tissue NHL before biopsy remains challenging. We investigated the diagnostic value of serum soluble interleukin-2 receptor (sIL-2R) levels and magnetic resonance imaging (MRI) as an initial tool to assess the likelihood of soft tissue NHL.

Methods

We analyzed 36 cases of pathologically proven soft tissue NHL initially suspected as soft tissue tumors alongside 48 control cases of soft tissue sarcoma or carcinoma. Patient medical charts and MRI scans were retrospectively reviewed and statistically analyzed, focusing on assessing the diagnostic efficacy of soft tissue NHL.

Results

The diagnostic accuracy of soft tissue NHL combining the appearance of homogeneity on MRI (T2-weighted and/or short-time inversion recovery [STIR] images) and sIL-2R value (≧ 904 U/mL) yielded a sensitivity of 78 % and 86 %, and specificity of 83 % and 88 %, respectively. Meeting one or both criteria increased the sensitivity to a maximum of 92 %, albeit with a specificity of 71 %. When both criteria were met, sensitivity and specificity were 72 % and 100 %, respectively.

Conclusion

The integrated approach of combining MRI and sIL-2R demonstrated excellent efficacy in predicting the diagnosis of soft tissue NHL, which was initially referred to as soft tissue tumor.

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诊断难题：软组织非霍奇金淋巴瘤中磁共振成像与血清可溶性白细胞介素-2 受体的结合应用

目的非霍奇金淋巴瘤（NHL）有时会发生在软组织中（称为软组织淋巴瘤或软组织NHL），通常与软组织肿瘤相似。尽管有一些临床指标，但在活检前准确诊断软组织NHL仍具有挑战性。我们研究了血清可溶性白细胞介素-2受体（sIL-2R）水平和磁共振成像（MRI）作为评估软组织NHL可能性的初始工具的诊断价值。结果结合核磁共振成像（T2加权和/或短时反转恢复[STIR]图像）显示的均匀性和sIL-2R值（≧ 904 U/mL），软组织NHL的诊断准确率分别为78%和86%，特异性分别为83%和88%。符合一个或两个标准可将灵敏度提高到最高 92%，但特异性仅为 71%。结论结合 MRI 和 sIL-2R 的综合方法在预测软组织 NHL（最初被称为软组织肿瘤）的诊断方面表现出卓越的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of orthopaedics ORTHOPEDICS-

CiteScore

3.50

自引率

6.70%

发文量

202

审稿时长

56 days

期刊介绍： Journal of Orthopaedics aims to be a leading journal in orthopaedics and contribute towards the improvement of quality of orthopedic health care. The journal publishes original research work and review articles related to different aspects of orthopaedics including Arthroplasty, Arthroscopy, Sports Medicine, Trauma, Spine and Spinal deformities, Pediatric orthopaedics, limb reconstruction procedures, hand surgery, and orthopaedic oncology. It also publishes articles on continuing education, health-related information, case reports and letters to the editor. It is requested to note that the journal has an international readership and all submissions should be aimed at specifying something about the setting in which the work was conducted. Authors must also provide any specific reasons for the research and also provide an elaborate description of the results.