Pub Date : 2026-05-01Epub Date: 2026-02-05DOI: 10.1016/j.jor.2026.02.031
Yong Huang , Chao Lou , Michael Jagodzinski
Background
Arthrofibrosis is a frequent complication after total knee arthroplasty (TKA) and remains difficult to diagnose early due to the lack of reliable biomarkers. Excessive extracellular matrix (ECM) remodeling is driven by core signaling cascades, notably the Transforming Growth Factor-beta 1 (TGF-ß1) and Wnt/ß-catenin pathways. Xylosyltransferase-I (XT-I), a key enzyme regulating proteoglycan biosynthesis, has emerged as a critical downstream effector and potential indicator of early fibrotic activity.
Methods
This narrative review summarizes clinical and experimental findings on XT-I in joint fibrosis, with emphasis on its role within the molecular network of key pro-fibrotic signaling and its diagnostic and translational potential in knee arthrofibrosis.
Results
XT-I is consistently upregulated in fibrotic synovial fibroblasts and synovial fluid of arthrofibrotic knees, correlating with ECM remodeling and myofibroblast activation induced by both TGF-ß1and Wnt/ß-catenin signaling. XT-I demonstrates local rather than systemic diagnostic value and may serve as an early fibrosis indicator.
Conclusion
XT-I holds promise as a synovial biomarker and potential therapeutic target in arthrofibrosis. Targeting XT-I, potentially in combination with core pathway inhibitors (e.g., Wnt/ß-catenin inhibitors), may offer a refined strategy for early diagnosis and postoperative management in TKA patients.
{"title":"Xylosyltransferase-I in knee arthrofibrosis: Mechanistic insights and translational implications","authors":"Yong Huang , Chao Lou , Michael Jagodzinski","doi":"10.1016/j.jor.2026.02.031","DOIUrl":"10.1016/j.jor.2026.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Arthrofibrosis is a frequent complication after total knee arthroplasty (TKA) and remains difficult to diagnose early due to the lack of reliable biomarkers. Excessive extracellular matrix (ECM) remodeling is driven by core signaling cascades, notably the Transforming Growth Factor-beta 1 (TGF-ß1) and Wnt/ß-catenin pathways. Xylosyltransferase-I (XT-I), a key enzyme regulating proteoglycan biosynthesis, has emerged as a critical downstream effector and potential indicator of early fibrotic activity.</div></div><div><h3>Methods</h3><div>This narrative review summarizes clinical and experimental findings on XT-I in joint fibrosis, with emphasis on its role within the molecular network of key pro-fibrotic signaling and its diagnostic and translational potential in knee arthrofibrosis.</div></div><div><h3>Results</h3><div>XT-I is consistently upregulated in fibrotic synovial fibroblasts and synovial fluid of arthrofibrotic knees, correlating with ECM remodeling and myofibroblast activation induced by both TGF-ß1and Wnt/ß-catenin signaling. XT-I demonstrates local rather than systemic diagnostic value and may serve as an early fibrosis indicator.</div></div><div><h3>Conclusion</h3><div>XT-I holds promise as a synovial biomarker and potential therapeutic target in arthrofibrosis. Targeting XT-I, potentially in combination with core pathway inhibitors (e.g., Wnt/ß-catenin inhibitors), may offer a refined strategy for early diagnosis and postoperative management in TKA patients.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 40-45"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-10DOI: 10.1016/j.jor.2026.02.043
Lindsay Maier , Zachary Chen , Mithil Gudi , Spencer Barlow , Trae Hill , Charles S. Day
Objectives
To evaluate the existing literature on value comparisons between treatment strategies in orthopaedic hip fracture care using real-world clinical data and standardized cost-effectiveness metrics.
Materials and Methods
Data sources
A comprehensive search of PubMed, Embase, and Web of Science was conducted for studies published between January 1, 2003, and May 30, 2024. Only English-language articles were included.
Study selection
Eligible studies directly compared two or more treatment strategies for hip fracture care and included a value-based economic evaluation using clinical (non-simulated) data. Exclusion criteria included simulation models, protocols, case reports, systematic reviews, and meta-analyses.
Data extraction
Two independent reviewers screened titles, abstracts, and full texts using PRISMA guidelines. Discrepancies were resolved by a third reviewer. Extracted variables included study design, intervention type, cost perspective, quality metric used, and economic evaluation method.
Data synthesis
Studies were analyzed descriptively. Outcome measures included cost-effectiveness ratios such as ICER, ICUR, and NMB. QALYs were used to enable cross-study comparisons.
Results
Sixteen of 935 screened full-text articles met inclusion criteria. Most studies evaluated surgical interventions. Cemented hemiarthroplasty showed a favorable NMB compared to uncemented implants. Liposomal bupivacaine and tranexamic acid were cost-effective due to lower operating costs and shorter hospital stays. Internal fixation was more cost-effective than hemiarthroplasty in some settings despite lower quality outcomes. Operative treatment in frail, institutionalized patients offered minimal QALY benefit at high cost. Home-based post-acute care and fracture liaison services improved value, while outreach rehab lacked long-term cost-effectiveness. Most studies used public payer perspectives and EQ-5D-derived QALYs.
Conclusion
There is significant variability in how value is calculated and reported in hip fracture care. Standardized value frameworks using a hospital/clinic perspective, patient-reported outcomes transformed into QALYs, and cost-utility ratios compared with the ICER equation should be utilized in future studies.
Level of evidence
Level III (Systematic Review of Comparative Studies)
目的利用真实世界的临床数据和标准化的成本-效果指标对骨科髋部骨折治疗策略的价值比较进行评估。资料与方法数据来源对2003年1月1日至2024年5月30日期间发表的研究进行了PubMed、Embase和Web of Science的综合检索。只包括英文文章。研究选择:符合条件的研究直接比较髋部骨折护理的两种或多种治疗策略,并使用临床(非模拟)数据进行基于价值的经济评估。排除标准包括模拟模型、方案、病例报告、系统评价和荟萃分析。数据提取:两名独立审稿人使用PRISMA指南筛选标题、摘要和全文。差异由第三位审稿人解决。提取的变量包括研究设计、干预类型、成本视角、使用的质量度量和经济评价方法。数据综合:对研究进行描述性分析。结果测量包括成本-效果比,如ICER、ICUR和NMB。使用质量分析来进行交叉研究比较。结果935篇筛选的全文文章中有16篇符合纳入标准。大多数研究评估手术干预。与非骨水泥植入物相比,骨水泥半关节置换术显示出良好的NMB。布比卡因和氨甲环酸脂质体由于较低的操作成本和较短的住院时间而具有成本效益。尽管结果质量较低,但在某些情况下,内固定比半关节置换术更具成本效益。对于体弱的住院患者,手术治疗在高成本下提供了最低的质量效益。以家庭为基础的急性后护理和骨折联络服务提高了价值,而外展康复缺乏长期的成本效益。大多数研究使用公共付款人的观点和eq - 5d衍生的质量分析。结论髋部骨折护理中价值的计算和报道存在显著差异。采用医院/诊所视角的标准化价值框架,将患者报告的结果转化为质量质量年,并将成本效用比与ICER方程进行比较,应在未来的研究中加以利用。证据水平III级(比较研究系统综述)
{"title":"Calculating and comparing value in orthopaedic hip trauma: A systematic review","authors":"Lindsay Maier , Zachary Chen , Mithil Gudi , Spencer Barlow , Trae Hill , Charles S. Day","doi":"10.1016/j.jor.2026.02.043","DOIUrl":"10.1016/j.jor.2026.02.043","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the existing literature on value comparisons between treatment strategies in orthopaedic hip fracture care using real-world clinical data and standardized cost-effectiveness metrics.</div><div>Materials and Methods</div></div><div><h3>Data sources</h3><div>A comprehensive search of PubMed, Embase, and Web of Science was conducted for studies published between January 1, 2003, and May 30, 2024. Only English-language articles were included.</div></div><div><h3>Study selection</h3><div>Eligible studies directly compared two or more treatment strategies for hip fracture care and included a value-based economic evaluation using clinical (non-simulated) data. Exclusion criteria included simulation models, protocols, case reports, systematic reviews, and meta-analyses.</div></div><div><h3>Data extraction</h3><div>Two independent reviewers screened titles, abstracts, and full texts using PRISMA guidelines. Discrepancies were resolved by a third reviewer. Extracted variables included study design, intervention type, cost perspective, quality metric used, and economic evaluation method.</div></div><div><h3>Data synthesis</h3><div>Studies were analyzed descriptively. Outcome measures included cost-effectiveness ratios such as ICER, ICUR, and NMB. QALYs were used to enable cross-study comparisons.</div></div><div><h3>Results</h3><div>Sixteen of 935 screened full-text articles met inclusion criteria. Most studies evaluated surgical interventions. Cemented hemiarthroplasty showed a favorable NMB compared to uncemented implants. Liposomal bupivacaine and tranexamic acid were cost-effective due to lower operating costs and shorter hospital stays. Internal fixation was more cost-effective than hemiarthroplasty in some settings despite lower quality outcomes. Operative treatment in frail, institutionalized patients offered minimal QALY benefit at high cost. Home-based post-acute care and fracture liaison services improved value, while outreach rehab lacked long-term cost-effectiveness. Most studies used public payer perspectives and EQ-5D-derived QALYs.</div></div><div><h3>Conclusion</h3><div>There is significant variability in how value is calculated and reported in hip fracture care. Standardized value frameworks using a hospital/clinic perspective, patient-reported outcomes transformed into QALYs, and cost-utility ratios compared with the ICER equation should be utilized in future studies.</div></div><div><h3>Level of evidence</h3><div>Level III (Systematic Review of Comparative Studies)</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 168-176"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-04DOI: 10.1016/j.jor.2026.02.027
Danielle B. Heckert , Julia Jezykowski , Clare K. Green , Joyce En-Hua Wang , Ved A. Vengsarkar , Wendy Novicoff , Xudong Li , Stephen Lockey
Introduction
Patients with myasthenia gravis (MG) are at higher risk for postoperative complications after surgery. Knowledge concerning the impact of the condition on outcomes and complications after spine surgery is currently limited. Using a large-scale, national database, the purpose of this investigation was to compare the rate of medical and surgical complications, healthcare utilization, and need for revision surgery following single-level lumbar fusion between patients with and without MG.
Methods
Data was collected using the PearlDiver database and adult patients with and without MG who underwent single-level lumbar spine fusion from 2010 to 2022 were matched 1:4 on age, sex, and baselin comorbidities. Pearson's Chi-squared test and Welch's t-test were used to evaluate differences in demographic and clinical outcomes. Univariate analysis and multivariate logistic regression were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) after controlling for potential confounders.
Results
A total of 537 (20.0%) patients with MG were matched with 2140 (80.0%) patients controls. At 90 days postoperatively, patients with MG experienced significantly higher rates of postoperative arrhythmia, cerebrovascular accident, atelectasis, respiratory failure, pleural effusion, pulmonary embolism, urinary retention, urinary tract infection, and renal failure. At two-year follow up, 27 (5.0%) patients with MG developed pseudoarthrosis compared to 48 (2.2%) controls (OR 2.32; 95% CI: 1.41-3.74; p < 0.001), and 38 (7.1%) MG patients had undergone revision lumbar spine surgery compared to 61 (2.9%) controls (OR: 2.61; 95% CI: 1.70-3.95; p < 0.001). Regarding healthcare utilization, patients with MG were more likely to present to the emergency department and require readmission at both 30 and 90 days postoperatively.
Conclusion
Patients with MG experienced more postoperative complications and higher healthcare utilization after single-level lumbar fusion. These findings highlight the importance of individualized perioperative planning to mitigate risks and inform surgeon counseling of patients and their families.
重症肌无力(MG)患者术后并发症发生率较高。目前关于脊柱手术后病情对预后和并发症的影响的知识有限。使用一个大规模的国家数据库,本研究的目的是比较有MG和无MG患者单节段腰椎融合术后的内科和外科并发症的发生率、医疗保健的利用以及翻修手术的需要。方法使用PearlDiver数据库收集数据,2010年至2022年接受单节段腰椎融合术的成年MG和非MG患者在年龄、性别和基线合并症方面按1:4匹配。使用Pearson卡方检验和Welch t检验来评估人口学和临床结果的差异。在控制潜在混杂因素后,进行单因素分析和多因素logistic回归计算优势比(ORs)和95%置信区间(CIs)。结果537例MG患者(20.0%)与对照组2140例(80.0%)匹配。在术后90天,MG患者出现术后心律失常、脑血管意外、肺不张、呼吸衰竭、胸腔积液、肺栓塞、尿潴留、尿路感染和肾功能衰竭的发生率明显较高。在两年的随访中,27例(5.0%)MG患者发生假关节,而对照组为48例(2.2%)(OR 2.32; 95% CI: 1.41-3.74; p < 0.001), 38例(7.1%)MG患者接受了腰椎翻修手术,而对照组为61例(2.9%)(OR: 2.61; 95% CI: 1.70-3.95; p < 0.001)。在医疗保健利用方面,MG患者更有可能出现在急诊科,并在术后30天和90天再次入院。结论单节段腰椎融合术后MG患者并发症较多,医疗保健利用率较高。这些发现强调了个体化围手术期计划的重要性,以减轻风险,并告知外科医生对患者及其家属的咨询。
{"title":"Outcomes following single-level lumbar fusion in patients with myasthenia gravis","authors":"Danielle B. Heckert , Julia Jezykowski , Clare K. Green , Joyce En-Hua Wang , Ved A. Vengsarkar , Wendy Novicoff , Xudong Li , Stephen Lockey","doi":"10.1016/j.jor.2026.02.027","DOIUrl":"10.1016/j.jor.2026.02.027","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with myasthenia gravis (MG) are at higher risk for postoperative complications after surgery. Knowledge concerning the impact of the condition on outcomes and complications after spine surgery is currently limited. Using a large-scale, national database, the purpose of this investigation was to compare the rate of medical and surgical complications, healthcare utilization, and need for revision surgery following single-level lumbar fusion between patients with and without MG.</div></div><div><h3>Methods</h3><div>Data was collected using the PearlDiver database and adult patients with and without MG who underwent single-level lumbar spine fusion from 2010 to 2022 were matched 1:4 on age, sex, and baselin comorbidities. Pearson's Chi-squared test and Welch's <em>t</em>-test were used to evaluate differences in demographic and clinical outcomes. Univariate analysis and multivariate logistic regression were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) after controlling for potential confounders.</div></div><div><h3>Results</h3><div>A total of 537 (20.0%) patients with MG were matched with 2140 (80.0%) patients controls. At 90 days postoperatively, patients with MG experienced significantly higher rates of postoperative arrhythmia, cerebrovascular accident, atelectasis, respiratory failure, pleural effusion, pulmonary embolism, urinary retention, urinary tract infection, and renal failure. At two-year follow up, 27 (5.0%) patients with MG developed pseudoarthrosis compared to 48 (2.2%) controls (OR 2.32; 95% CI: 1.41-3.74; p < 0.001), and 38 (7.1%) MG patients had undergone revision lumbar spine surgery compared to 61 (2.9%) controls (OR: 2.61; 95% CI: 1.70-3.95; p < 0.001). Regarding healthcare utilization, patients with MG were more likely to present to the emergency department and require readmission at both 30 and 90 days postoperatively.</div></div><div><h3>Conclusion</h3><div>Patients with MG experienced more postoperative complications and higher healthcare utilization after single-level lumbar fusion. These findings highlight the importance of individualized perioperative planning to mitigate risks and inform surgeon counseling of patients and their families.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 57-61"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study evaluated stress distribution across the entire pelvis following rotational acetabular osteotomy (RAO) for osteoarthritis secondary to acetabular dysplasia using finite element analysis (FEA). Additionally, we aimed to elucidate the mechanisms underlying postoperative posterior column and inferior pubic ramus fractures, which are recognized complications of RAO.
Methods
FEA was conducted based on the computed tomography (CT) images of a 26-year-old female patient who developed a posterior column fracture following RAO. Three pelvic models were constructed: preoperative, immediately postoperative, and 1 year postoperatively, in which osseous union was achieved between the rotated fragment and the ilium; however, the osteotomy site at the superior pubic ramus resulted in nonunion. Additionally, a Union model, simulating the continuity of the superior pubic ramus in both postoperative stages, was created for comparison with the Nonunion model. A load of 500 N was applied in a sitting position, with the von Mises stress distribution and element failure patterns analyzed.
Results
In the Nonunion model, von Mises stress at the inferior pubic ramus was approximately 3.6 times higher immediately after surgery than preoperatively (43.0 MPa) and approximately 2.6 times higher than in the Union model. Similarly, the stress in the posterior column increased approximately 5.1-fold (53.9 MPa) immediately postoperatively in the Nonunion model, which was approximately 3.2 times higher (34.2 MPa) than in the Union model. Furthermore, element failure was observed in areas where stress exceeded 30 MPa, with a high incidence of failure in the immediate postoperative Nonunion model.
Conclusion
Early post-RAO fractures of the posterior column and inferior pubic ramus are significantly influenced by the continuity of the superior pubic ramus. Notably, even before weight-bearing begins, the presence of a gap at the pubic osteotomy site immediately after RAO may substantially elevate fracture risk.
{"title":"Evaluation of early pelvic Fracture risk after rotational acetabular osteotomy: Finite element analysis of pelvic stress distribution","authors":"Tsuguaki Hosoyama , Nobuhiro Kaku , Yutaro Shibuta , Kensei Tanaka","doi":"10.1016/j.jor.2026.02.022","DOIUrl":"10.1016/j.jor.2026.02.022","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated stress distribution across the entire pelvis following rotational acetabular osteotomy (RAO) for osteoarthritis secondary to acetabular dysplasia using finite element analysis (FEA). Additionally, we aimed to elucidate the mechanisms underlying postoperative posterior column and inferior pubic ramus fractures, which are recognized complications of RAO.</div></div><div><h3>Methods</h3><div>FEA was conducted based on the computed tomography (CT) images of a 26-year-old female patient who developed a posterior column fracture following RAO. Three pelvic models were constructed: preoperative, immediately postoperative, and 1 year postoperatively, in which osseous union was achieved between the rotated fragment and the ilium; however, the osteotomy site at the superior pubic ramus resulted in nonunion. Additionally, a Union model, simulating the continuity of the superior pubic ramus in both postoperative stages, was created for comparison with the Nonunion model. A load of 500 N was applied in a sitting position, with the von Mises stress distribution and element failure patterns analyzed.</div></div><div><h3>Results</h3><div>In the Nonunion model, von Mises stress at the inferior pubic ramus was approximately 3.6 times higher immediately after surgery than preoperatively (43.0 MPa) and approximately 2.6 times higher than in the Union model. Similarly, the stress in the posterior column increased approximately 5.1-fold (53.9 MPa) immediately postoperatively in the Nonunion model, which was approximately 3.2 times higher (34.2 MPa) than in the Union model. Furthermore, element failure was observed in areas where stress exceeded 30 MPa, with a high incidence of failure in the immediate postoperative Nonunion model.</div></div><div><h3>Conclusion</h3><div>Early post-RAO fractures of the posterior column and inferior pubic ramus are significantly influenced by the continuity of the superior pubic ramus. Notably, even before weight-bearing begins, the presence of a gap at the pubic osteotomy site immediately after RAO may substantially elevate fracture risk.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 120-125"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-04DOI: 10.1016/j.jor.2026.02.012
Michael J. Archibeck, Brenna E. Blackburn, Claire R. Kapron, Lucas A. Anderson, Jeremy M. Gililland, Christopher L. Peters, Christopher E. Pelt
Introduction
The popularity of modular dual mobility (MDM) acetabular components has increased. Concerns have been raised about the potential for corrosion related complications in these modular implants. The purpose of this study was to prospectively monitor serum ion levels in a series of patients with a modular dual mobility system.
Methods
Twenty-six patients with the Zimmer Biomet G7 DM construct were enrolled and followed for a minimum of one year. Serum cobalt, chromium, and titanium levels were obtained prior to six-weeks postoperatively and at one and two-years postoperatively. Five-year labs were obtained if previous labs were elevated.
Results
At 0-6 weeks postoperatively, 4/26 patients had mildly elevated cobalt levels (1-2.8 μg/L) and 2/26 had mildly elevated chromium levels (1.6, 2.0 μg/L). None of the 19 patients showed elevated cobalt levels at one or two years, while 4/19 reported mildly elevated chromium levels (1.1-1.3 μg/L) at one-year with a slight decrease (1-1.4 μg/L) at two-years. No patients at any time point had metal ion levels exceeding the initial early threshold of 5 μg/L. No patient was symptomatic and no MRIs were indicated or obtained.
Discussion
In this series of a specific modular DM system, the early mildly elevated cobalt levels in four patients all subsequently normalized. Chromium was mildly elevated in four patients through year two. While these findings are reassuring in the short term as mildly elevated chromium (<2 μg/L) has not been associated with clinical toxicity, additional follow-up is needed to establish the long-term safety and efficacy of this specific modular DM implant.
{"title":"Reassuring early serum metal ion levels with a specific modular dual mobility system","authors":"Michael J. Archibeck, Brenna E. Blackburn, Claire R. Kapron, Lucas A. Anderson, Jeremy M. Gililland, Christopher L. Peters, Christopher E. Pelt","doi":"10.1016/j.jor.2026.02.012","DOIUrl":"10.1016/j.jor.2026.02.012","url":null,"abstract":"<div><h3>Introduction</h3><div>The popularity of modular dual mobility (MDM) acetabular components has increased. Concerns have been raised about the potential for corrosion related complications in these modular implants. The purpose of this study was to prospectively monitor serum ion levels in a series of patients with a modular dual mobility system.</div></div><div><h3>Methods</h3><div>Twenty-six patients with the Zimmer Biomet G7 DM construct were enrolled and followed for a minimum of one year. Serum cobalt, chromium, and titanium levels were obtained prior to six-weeks postoperatively and at one and two-years postoperatively. Five-year labs were obtained if previous labs were elevated.</div></div><div><h3>Results</h3><div>At 0-6 weeks postoperatively, 4/26 patients had mildly elevated cobalt levels (1-2.8 μg/L) and 2/26 had mildly elevated chromium levels (1.6, 2.0 μg/L). None of the 19 patients showed elevated cobalt levels at one or two years, while 4/19 reported mildly elevated chromium levels (1.1-1.3 μg/L) at one-year with a slight decrease (1-1.4 μg/L) at two-years. No patients at any time point had metal ion levels exceeding the initial early threshold of 5 μg/L. No patient was symptomatic and no MRIs were indicated or obtained.</div></div><div><h3>Discussion</h3><div>In this series of a specific modular DM system, the early mildly elevated cobalt levels in four patients all subsequently normalized. Chromium was mildly elevated in four patients through year two. While these findings are reassuring in the short term as mildly elevated chromium (<2 μg/L) has not been associated with clinical toxicity, additional follow-up is needed to establish the long-term safety and efficacy of this specific modular DM implant.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 6-11"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-03DOI: 10.1016/j.jor.2026.02.020
Cailan L. Feingold , Eric H. Lin , Andrew B. Barcenas , Brandon A. Young , Ji S. Chin , Austin V. Stone , Joseph N. Liu
Purpose
Isolated lateral release (LR) and lateral lengthening (LL) may have a role in the management of knee pain without instability, but these indications have not been clearly defined. This study sought to evaluate the use of isolated lateral release and lateral lengthening for non-instability indications of the knee.
Methods
PubMed, Embase, and Web of Science were queried for terms related to lateral release and lateral lengthening of the knee. Included studies investigated isolated LR or LL as an intervention for non-patellofemoral instability indications of the knee that were published in English and in peer-reviewed journals. Studies were excluded if they investigated LR or LL for patellofemoral instability or during total knee arthroplasty, published before 2000, systematic reviews, biomechanical studies, and case reports. Surgery indications, patient demographics, patient-reported outcome measures (PROMs), complications and subsequent surgeries, were collected.
Results
Seven studies with 404 patients were included, 4 of which investigated LR/LL for lateral patellar compression syndrome (LPCS), 1 for anterior knee pain, 1 for patellofemoral arthritis, and 1 for patellofemoral arthrofibrosis following anterior cruciate ligament reconstruction. All seven studies reported significant improvements in PROMs and clinical outcomes, regardless of indication. The most common complications were postoperative hemarthrosis, medial patellar instability, and fibrosis.
Conclusion
Isolated LR and LL are viable options for the management of LPCS, anterior knee pain, and postoperative patellofemoral arthrofibrosis that lead to improvements in PROMs. Medial patellar instability is a feared complication of LR/LL but appears to be more likely in patients undergoing LR.
Study design
Systematic Review; LOE IV
目的:孤立的外侧松解术(LR)和外侧延长术(LL)可能在无不稳定性的膝关节疼痛治疗中发挥作用,但这些适应症尚未明确定义。本研究旨在评估孤立的外侧松解和外侧延长在膝关节非不稳定指征中的应用。方法查询spubmed、Embase和Web of Science中与膝关节外侧松解和外侧延长相关的术语。纳入的研究调查了孤立的LR或LL作为膝关节非髌骨不稳指征的干预措施,这些研究已在英文和同行评审期刊上发表。在2000年之前发表的系统综述、生物力学研究和病例报告中,如果研究髌骨不稳定或全膝关节置换术期间的LR或LL,则排除。收集手术指征、患者人口统计学、患者报告的结果测量(PROMs)、并发症和随后的手术。结果纳入7项研究,共404例患者,其中4项研究LR/LL治疗外侧髌骨压迫综合征(LPCS), 1项治疗膝关节前侧疼痛,1项治疗髌股关节炎,1项治疗前交叉韧带重建后髌股关节纤维化。所有七项研究都报告了PROMs和临床结果的显著改善,无论适应症如何。最常见的并发症是术后关节出血、内侧髌骨不稳定和纤维化。结论孤立的LR和LL是治疗LPCS、膝关节前侧疼痛和术后髌股关节纤维化的可行选择,可改善PROMs。内侧髌骨不稳定是LR/LL的一种可怕的并发症,但在LR患者中似乎更容易发生。研究设计;系统评价;爱情第四
{"title":"Isolated lateral release or lateral lengthening for non-instability indications: A systematic review","authors":"Cailan L. Feingold , Eric H. Lin , Andrew B. Barcenas , Brandon A. Young , Ji S. Chin , Austin V. Stone , Joseph N. Liu","doi":"10.1016/j.jor.2026.02.020","DOIUrl":"10.1016/j.jor.2026.02.020","url":null,"abstract":"<div><h3>Purpose</h3><div>Isolated lateral release (LR) and lateral lengthening (LL) may have a role in the management of knee pain without instability, but these indications have not been clearly defined. This study sought to evaluate the use of isolated lateral release and lateral lengthening for non-instability indications of the knee.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and Web of Science were queried for terms related to lateral release and lateral lengthening of the knee. Included studies investigated isolated LR or LL as an intervention for non-patellofemoral instability indications of the knee that were published in English and in peer-reviewed journals. Studies were excluded if they investigated LR or LL for patellofemoral instability or during total knee arthroplasty, published before 2000, systematic reviews, biomechanical studies, and case reports. Surgery indications, patient demographics, patient-reported outcome measures (PROMs), complications and subsequent surgeries, were collected.</div></div><div><h3>Results</h3><div>Seven studies with 404 patients were included, 4 of which investigated LR/LL for lateral patellar compression syndrome (LPCS), 1 for anterior knee pain, 1 for patellofemoral arthritis, and 1 for patellofemoral arthrofibrosis following anterior cruciate ligament reconstruction. All seven studies reported significant improvements in PROMs and clinical outcomes, regardless of indication. The most common complications were postoperative hemarthrosis, medial patellar instability, and fibrosis.</div></div><div><h3>Conclusion</h3><div>Isolated LR and LL are viable options for the management of LPCS, anterior knee pain, and postoperative patellofemoral arthrofibrosis that lead to improvements in PROMs. Medial patellar instability is a feared complication of LR/LL but appears to be more likely in patients undergoing LR.</div></div><div><h3>Study design</h3><div>Systematic Review; LOE IV</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 62-66"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-11DOI: 10.1016/j.jor.2026.02.047
Zayd Chishti , Albert Brotgandel , Carson Balen , Rebecca Lipscomb , D. Trey Remaley , John Kiel
Objectives
To determine the incidence and demographic characteristics of combat sport-related fractures treated in U.S. emergency departments and compare demographic variables, injury characteristics, and disposition among boxing-, wrestling-, and martial arts (MA)-related fractures.
Methods
The National Electronic Injury Surveillance System (NEISS) was queried for boxing, wrestling, and MA-related fractures from 2014 to 2023. Analyses included descriptive statistics and comparative tests (chi-square, Fisher's, Mann-Whitney U, Kruskal-Wallis).
Results
Of 22,233 combat sport-related injuries, 4391 (19.7%) were fractures: 929 boxing (21.2%), 1938 wrestling (44.1%), and 1524 MA (34.7%). NEISS weighted estimates correspond to 80,182 injuries and 14,555 fractures annually. Fractures comprised the greatest proportion of total injuries in boxing (21.6%) (p = 0.002), and the mean age at the time of fracture was highest in the boxing group (25.18 ± 11.49 years) (p < 0.001). Boxing fractures most often involved the hand (50.4%), wrestling the shoulder (15.7%), and MA the toes (15.9%) (p < 0.001). Pediatric patients (<18 years) represented 64.9% of fractures, most commonly lower arm (15.2%), while adults most often sustained hand fractures (31.0%) (p < 0.001). Wrestling (88.2%) and MA (56.3%) fractures occurred mainly in pediatric patients, whereas boxing fractures were more frequent in adults (69.6%) (p < 0.001). Males accounted for 85.2% of fractures, most often involving the hand (16.7%), while females most frequently sustained shoulder fractures (14.5%) (p < 0.001). Patients with boxing fractures were the most likely to be treated and released (96.3%) (p < 0.001).
Conclusion
Combat sport-related fractures show distinct patterns by sport, age, and sex, insights that can inform targeted injury prevention and safety strategies.
{"title":"Epidemiology of combat sport-related fractures treated in United States emergency departments","authors":"Zayd Chishti , Albert Brotgandel , Carson Balen , Rebecca Lipscomb , D. Trey Remaley , John Kiel","doi":"10.1016/j.jor.2026.02.047","DOIUrl":"10.1016/j.jor.2026.02.047","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the incidence and demographic characteristics of combat sport-related fractures treated in U.S. emergency departments and compare demographic variables, injury characteristics, and disposition among boxing-, wrestling-, and martial arts (MA)-related fractures.</div></div><div><h3>Methods</h3><div>The National Electronic Injury Surveillance System (NEISS) was queried for boxing, wrestling, and MA-related fractures from 2014 to 2023. Analyses included descriptive statistics and comparative tests (chi-square, Fisher's, Mann-Whitney U, Kruskal-Wallis).</div></div><div><h3>Results</h3><div>Of 22,233 combat sport-related injuries, 4391 (19.7%) were fractures: 929 boxing (21.2%), 1938 wrestling (44.1%), and 1524 MA (34.7%). NEISS weighted estimates correspond to 80,182 injuries and 14,555 fractures annually. Fractures comprised the greatest proportion of total injuries in boxing (21.6%) (p = 0.002), and the mean age at the time of fracture was highest in the boxing group (25.18 ± 11.49 years) (p < 0.001). Boxing fractures most often involved the hand (50.4%), wrestling the shoulder (15.7%), and MA the toes (15.9%) (p < 0.001). Pediatric patients (<18 years) represented 64.9% of fractures, most commonly lower arm (15.2%), while adults most often sustained hand fractures (31.0%) (p < 0.001). Wrestling (88.2%) and MA (56.3%) fractures occurred mainly in pediatric patients, whereas boxing fractures were more frequent in adults (69.6%) (p < 0.001). Males accounted for 85.2% of fractures, most often involving the hand (16.7%), while females most frequently sustained shoulder fractures (14.5%) (p < 0.001). Patients with boxing fractures were the most likely to be treated and released (96.3%) (p < 0.001).</div></div><div><h3>Conclusion</h3><div>Combat sport-related fractures show distinct patterns by sport, age, and sex, insights that can inform targeted injury prevention and safety strategies.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 106-112"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-04DOI: 10.1016/j.jor.2026.02.016
Kenneth T. Nguyen , Erin L. Brown , Bhavesh R. Koppala , Daman P. Dhunna , Neil Samant , Hanna House , Alexander Kuzma , Nikolas Baksh
Purpose
Adult spinal deformity (ASD) affects approximately 68% of patients over age 65 and can significantly reduce quality of life. Posterior spinal fusion (PSF) is a common corrective procedure, but sociodemographic disparities may influence outcomes. This study evaluates the frequency of sociodemographic variable reporting in randomized controlled trials (RCTs) investigating PSF for ASD, hypothesizing significant underreporting and their potential as modifiable confounders of treatment outcomes.
Methods
A systematic literature review was conducted on April 15, 2024, in accordance with PRISMA guidelines using PubMed, Embase, and Scopus to identify RCTs on ASD and PSF. Studies were included if they were full-length RCTs and excluded if non-English, unavailable, cadaveric, technical, or non-RCT. Two spine surgeons independently screened studies, with a third reviewer resolving disagreements. Data on demographic and socioeconomic variables were extracted. Descriptive statistics and chi-squared or Fisher's exact tests (P < 0.05) were used for analysis.
Results
The search yielded 32 studies; after removing duplicates and ineligible studies, five RCTs published between 2008 and 2020 met inclusion criteria. All reported age and sex (100%), but none included race, ethnicity, employment, education, housing, or income, and only one reported insurance status (20%). Demographic and socioeconomic variables were significantly underreported compared to age and sex (P < 0.001), with no differences by journal or publication year.
Conclusion
Age and sex were consistently reported in ASD RCTs, but broader sociodemographic data were largely absent. Future trials should include these variables to better understand disparities and improve equitable care for ASD patients.
{"title":"Sociodemographic variables are rarely reported in randomized controlled trials investigating posterior spinal fusion for adult spinal deformity: A systematic review","authors":"Kenneth T. Nguyen , Erin L. Brown , Bhavesh R. Koppala , Daman P. Dhunna , Neil Samant , Hanna House , Alexander Kuzma , Nikolas Baksh","doi":"10.1016/j.jor.2026.02.016","DOIUrl":"10.1016/j.jor.2026.02.016","url":null,"abstract":"<div><h3>Purpose</h3><div>Adult spinal deformity (ASD) affects approximately 68% of patients over age 65 and can significantly reduce quality of life. Posterior spinal fusion (PSF) is a common corrective procedure, but sociodemographic disparities may influence outcomes. This study evaluates the frequency of sociodemographic variable reporting in randomized controlled trials (RCTs) investigating PSF for ASD, hypothesizing significant underreporting and their potential as modifiable confounders of treatment outcomes.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted on April 15, 2024, in accordance with PRISMA guidelines using PubMed, Embase, and Scopus to identify RCTs on ASD and PSF. Studies were included if they were full-length RCTs and excluded if non-English, unavailable, cadaveric, technical, or non-RCT. Two spine surgeons independently screened studies, with a third reviewer resolving disagreements. Data on demographic and socioeconomic variables were extracted. Descriptive statistics and chi-squared or Fisher's exact tests (P < 0.05) were used for analysis.</div></div><div><h3>Results</h3><div>The search yielded 32 studies; after removing duplicates and ineligible studies, five RCTs published between 2008 and 2020 met inclusion criteria. All reported age and sex (100%), but none included race, ethnicity, employment, education, housing, or income, and only one reported insurance status (20%). Demographic and socioeconomic variables were significantly underreported compared to age and sex (P < 0.001), with no differences by journal or publication year.</div></div><div><h3>Conclusion</h3><div>Age and sex were consistently reported in ASD RCTs, but broader sociodemographic data were largely absent. Future trials should include these variables to better understand disparities and improve equitable care for ASD patients.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 1-5"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-09DOI: 10.1016/j.jor.2026.02.037
Chang Hee Baek, Bo Taek Kim, Jung Gon Kim, Chaemoon Lim, Seung Jin Kim
Introduction
Complete anatomic repair of large to massive rotator cuff tears (RCTs) is often not feasible because of tendon retraction, poor tissue quality, and advanced muscle degeneration. This study evaluates short-term clinical outcomes, complications, and postoperative structural integrity following arthroscopic partial rotator cuff repair with patch augmentation in patients with large to massive rotator cuff tears.
Methods
From May 2023 to December 2023, patients who underwent arthroscopic partial rotator cuff repair with patch augmentation for large to massive RCTS were retrospectively reviewed. Inclusion criteria were full-thickness supraspinatus tears with or without infraspinatus involvement, anteroposterior tear size >30 mm, and intraoperative confirmation that complete footprint coverage was not achievable. Exclusion criteria were loss to follow-up, prior shoulder instability surgery, and incomplete clinical data. Clinical outcomes were assessed preoperatively and at final follow-up using VAS pain, Constant, ASES, and SANE scores, range of motion (ROM), and forward elevation strength. Postoperative cuff integrity was evaluated with MRI, with subgroup analyses based on repair integrity.
Results
After exclusion of 16 patients, 90 patients were included, with a mean follow-up duration of 26.3 ± 2.1 months. Significant improvements were observed in pain, patient-reported outcome measures, ROM, and shoulder strength at final follow-up compared with preoperative values (all p < .001). Postoperative retear occurred in 18 patients (20.0%). Patients with intact repairs showed significantly superior pain relief, functional outcome scores, ROM, and strength compared with those who experienced retears (all p < .001). Other complications included shoulder stiffness in 8 patients (8.9%), infection in 2 patients (2.2%), and progression of glenohumeral arthritis in 3 patients (3.3%).
Conclusion
Arthroscopic partial repair with patch augmentation resulted in significant short-term improvements in pain, functional outcomes, ROM, and shoulder strength in patients with large to massive RCTs. Patients with intact repairs demonstrated superior clinical outcomes and achieved higher rates of clinically meaningful improvement compared with those in the retear group.
{"title":"Clinical outcomes and structural integrity after arthroscopic partial repair with patch augmentation for large to massive rotator cuff tears","authors":"Chang Hee Baek, Bo Taek Kim, Jung Gon Kim, Chaemoon Lim, Seung Jin Kim","doi":"10.1016/j.jor.2026.02.037","DOIUrl":"10.1016/j.jor.2026.02.037","url":null,"abstract":"<div><h3>Introduction</h3><div>Complete anatomic repair of large to massive rotator cuff tears (RCTs) is often not feasible because of tendon retraction, poor tissue quality, and advanced muscle degeneration. This study evaluates short-term clinical outcomes, complications, and postoperative structural integrity following arthroscopic partial rotator cuff repair with patch augmentation in patients with large to massive rotator cuff tears.</div></div><div><h3>Methods</h3><div>From May 2023 to December 2023, patients who underwent arthroscopic partial rotator cuff repair with patch augmentation for large to massive RCTS were retrospectively reviewed. Inclusion criteria were full-thickness supraspinatus tears with or without infraspinatus involvement, anteroposterior tear size >30 mm, and intraoperative confirmation that complete footprint coverage was not achievable. Exclusion criteria were loss to follow-up, prior shoulder instability surgery, and incomplete clinical data. Clinical outcomes were assessed preoperatively and at final follow-up using VAS pain, Constant, ASES, and SANE scores, range of motion (ROM), and forward elevation strength. Postoperative cuff integrity was evaluated with MRI, with subgroup analyses based on repair integrity.</div></div><div><h3>Results</h3><div>After exclusion of 16 patients, 90 patients were included, with a mean follow-up duration of 26.3 ± 2.1 months. Significant improvements were observed in pain, patient-reported outcome measures, ROM, and shoulder strength at final follow-up compared with preoperative values (all p < .001). Postoperative retear occurred in 18 patients (20.0%). Patients with intact repairs showed significantly superior pain relief, functional outcome scores, ROM, and strength compared with those who experienced retears (all p < .001). Other complications included shoulder stiffness in 8 patients (8.9%), infection in 2 patients (2.2%), and progression of glenohumeral arthritis in 3 patients (3.3%).</div></div><div><h3>Conclusion</h3><div>Arthroscopic partial repair with patch augmentation resulted in significant short-term improvements in pain, functional outcomes, ROM, and shoulder strength in patients with large to massive RCTs. Patients with intact repairs demonstrated superior clinical outcomes and achieved higher rates of clinically meaningful improvement compared with those in the retear group.</div></div><div><h3>Study design</h3><div>Case series; Level of evidence, IV.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 148-153"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-05-01Epub Date: 2026-02-05DOI: 10.1016/j.jor.2026.01.019
Zeremy Tang , Ryan Wai Keong Loke , Jonathan Jia En Boey , Alexander Xi Xuan Ang , Darren Keng Jin Tay
Background
Unstable intertrochanteric hip fractures remain prevalent in the elderly with impacts on function and quality of life. Both hemiarthroplasty and internal fixation methods have been surgical options, with consensus yet to be reached on the optimal approach. This review compares intraoperative and postoperative clinical outcomes between the two techniques.
Methods
Systematic review and meta-analysis was conducted, searching four databases for studies on patients who received either internal fixation (IF) or hemiarthroplasty (HA) for unstable intertrochanteric hip fractures. The primary outcome was Harris Hip Score (HHS), with secondary outcomes of intraoperative and postoperative clinical findings. Intra-study risk of bias was graded using ROBINS-I and Cochrane Risk-of-Bias tool, with assessment of evidence certainty using the GRADE approach.
Results
HHS for HA was significantly greater at 3 and 6-month post-operation compared to IF, with a weighted mean difference of 12.5 (95% CI: 8.6-16.4) and 5.3 (95% CI: 2.9-7.7) respectively. Furthermore, HA's relative risk (RR) of reoperations was lower at 0.6 (95% CI: 0.3-1.0), RR of nonunion of fractures was lower at 0.5 (95% CI: 0.3 - 0.9) and RR of prosthesis failure lower at 0.4 (95% CI: 0.2-1.0). Intraoperatively, HA had a longer operation time by 12.2 min (95% CI: 6.6-17.9) and greater blood loss of 152.8 mL (95% CI: 108.1-197.6). Post-operatively, HA had a higher RR of 1-year mortality rate at 1.6 (95% CI: 1.2 - 2.1) and higher RR of SSI at 1.4 (95% CI: 1.0-2.1). Otherwise, there is no difference in post-operative complications of deep vein thrombosis, limb length deformity and periprosthetic fractures.
Conclusion
HA provided superior early functional outcome and a reduced relative risk of mechanical complications at the cost of increased intraoperative burden, higher early post-operative mortality and SSI risk. IF hence offers lowered intraoperative stress and reduced post-operative morbidity. Surgical choice should ultimately be individualised based on patient priorities and risk profile.
{"title":"Hemiarthroplasty for unstable intertrochanteric hip fractures: A systematic review and meta-analysis","authors":"Zeremy Tang , Ryan Wai Keong Loke , Jonathan Jia En Boey , Alexander Xi Xuan Ang , Darren Keng Jin Tay","doi":"10.1016/j.jor.2026.01.019","DOIUrl":"10.1016/j.jor.2026.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Unstable intertrochanteric hip fractures remain prevalent in the elderly with impacts on function and quality of life. Both hemiarthroplasty and internal fixation methods have been surgical options, with consensus yet to be reached on the optimal approach. This review compares intraoperative and postoperative clinical outcomes between the two techniques.</div></div><div><h3>Methods</h3><div>Systematic review and meta-analysis was conducted, searching four databases for studies on patients who received either internal fixation (IF) or hemiarthroplasty (HA) for unstable intertrochanteric hip fractures. The primary outcome was Harris Hip Score (HHS), with secondary outcomes of intraoperative and postoperative clinical findings. Intra-study risk of bias was graded using ROBINS-I and Cochrane Risk-of-Bias tool, with assessment of evidence certainty using the GRADE approach.</div></div><div><h3>Results</h3><div>HHS for HA was significantly greater at 3 and 6-month post-operation compared to IF, with a weighted mean difference of 12.5 (95% CI: 8.6-16.4) and 5.3 (95% CI: 2.9-7.7) respectively. Furthermore, HA's relative risk (RR) of reoperations was lower at 0.6 (95% CI: 0.3-1.0), RR of nonunion of fractures was lower at 0.5 (95% CI: 0.3 - 0.9) and RR of prosthesis failure lower at 0.4 (95% CI: 0.2-1.0). Intraoperatively, HA had a longer operation time by 12.2 min (95% CI: 6.6-17.9) and greater blood loss of 152.8 mL (95% CI: 108.1-197.6). Post-operatively, HA had a higher RR of 1-year mortality rate at 1.6 (95% CI: 1.2 - 2.1) and higher RR of SSI at 1.4 (95% CI: 1.0-2.1). Otherwise, there is no difference in post-operative complications of deep vein thrombosis, limb length deformity and periprosthetic fractures.</div></div><div><h3>Conclusion</h3><div>HA provided superior early functional outcome and a reduced relative risk of mechanical complications at the cost of increased intraoperative burden, higher early post-operative mortality and SSI risk. IF hence offers lowered intraoperative stress and reduced post-operative morbidity. Surgical choice should ultimately be individualised based on patient priorities and risk profile.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 73-81"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}