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Relationship between social determinants of health and hip fracture in the American population: a cross-sectional NHANES study 美国人群健康的社会决定因素与髋部骨折之间的关系:一项横断面NHANES研究
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-01-12 DOI: 10.1016/j.jor.2026.01.008
Fangfang Deng, Huali Guo, Li Song, Bo Chen

Background

This article aims to investigate the link between social determinants of health (SDoH) and the occurrence of hip fractures, and to analyze the potential underlying mechanisms of influence.

Methods

This paper conducted a deep analysis among the general sample population from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. Within each survey period, self-reported data covering eight domains of SDoH were collected, including employment status, poverty-to-income ratio (PIR), food security, educational level, health insurance coverage, type of health insurance, homeownership, and marital status. Concurrently, a history of hip fractures among participants was learned through self-reporting. Correlation analysis, Lasso regression analysis, and the Boruta algorithm were employed to explore the link between SDoH and hip fractures.

Results

This study comprehensively analyzed 11,254 adult participants. The findings indicated a notable link between eight sub-items of SDoH and the risk of hip fracture. Specifically, the cumulative number of adverse SDoH was positively linked with the risk of hip fracture. Especially as 4-7 adverse factors were accumulated, the incidence of hip fractures climbed greatly.

Conclusion

This paper suggests a marked link between adverse SDoH and the occurrence of hip fractures, particularly when these adverse factors accumulate to a certain number (4–7). A profound probe into the interactions among these SDoH and their mechanisms of influence on fracture risk may offer crucial evidence for the prevention and intervention of hip fractures.
本文旨在探讨健康的社会决定因素(SDoH)与髋部骨折发生之间的联系,并分析其潜在的影响机制。方法对1999-2018年国家健康与营养检查调查(NHANES)的一般样本人群进行深入分析。在每个调查期间,收集了包括就业状况、贫困收入比(PIR)、粮食安全、教育水平、医疗保险覆盖率、医疗保险类型、住房所有权和婚姻状况在内的八个领域的自我报告数据。同时,参与者通过自我报告了解髋部骨折史。采用相关分析、Lasso回归分析和Boruta算法探讨SDoH与髋部骨折的关系。结果本研究综合分析了11254名成年参与者。研究结果表明,SDoH的8个分项与髋部骨折风险之间存在显著联系。具体而言,不良SDoH累积次数与髋部骨折风险呈正相关。特别是随着4-7个不良因素的累积,髋部骨折的发生率急剧攀升。结论本文认为不良SDoH与髋部骨折的发生有明显的联系,特别是当这些不良因素累积到一定数量时(4-7)。深入探讨这些SDoH之间的相互作用及其对骨折风险的影响机制,将为髋部骨折的预防和干预提供重要依据。
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引用次数: 0
Nonoperative management of sacral chordomas: A systematic review of the literature 骶脊索瘤的非手术治疗:文献的系统回顾
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-01-08 DOI: 10.1016/j.jor.2026.01.007
Sean Bae , Mark Ehioghae , Jonathan P. Japa , Ala Alshomali , Aaron Phung , Linus Lee , Justin Hyde , Jamie Lee , Kevin Yoon , Addisu Mesfin

Background

Sacral chordomas are rare malignant tumors arising from notochordal remnants that can be identified incidentally or present with sacral pain. Although surgical resection is the accepted standard treatment, some patients forgo surgery due to associated morbidity and complications. Nonoperative alternatives, including radiotherapies, have emerged, but literature on their outcomes remains scarce. The purpose of this study was to evaluate the outcomes of nonoperative management of sacral chordomas.

Methods

We conducted a systematic review of the literature utilizing PubMed. Search keywords included “nonoperative treatment,” “sacral chordomas,” “radiotherapy,” and “functional outcomes.” Studies involving sacral chordoma patients who underwent nonoperative treatment were included; patients with surgical treatment and hybrid therapies that included surgery were excluded from the analysis.

Results

Eleven clinical studies on nonoperative management of sacral chordomas with 52 patients aged between 35 and 85 years (mean = 62.8) were identified. Males were affected at higher rates than females (73.1 % vs 26.9 %). S1 (15.4 %) and S2 (25 %) were the most affected spinal segments. CT-guided biopsy was the most common method of tumor diagnosis (82.7 %). Carbon ion radiotherapy (CIRT) and proton beam therapy were the most common treatment methods, with 57.7 % of patients reporting recurrence-free survival at a mean follow-up of 24 months.

Conclusion

Nonoperative management of sacral chordomas shows promising outcomes for patients who are not candidates for surgery. Although recurrence remains a risk, nonoperative management may offer meaningful functional preservation and local disease control.
背景:骶脊索瘤是一种罕见的恶性肿瘤,起源于脊索残余,可偶然发现或伴有骶痛。虽然手术切除是公认的标准治疗方法,但由于相关的发病率和并发症,一些患者放弃手术。包括放射治疗在内的非手术替代疗法已经出现,但关于其结果的文献仍然很少。本研究的目的是评估非手术治疗骶脊索瘤的结果。方法利用PubMed对相关文献进行系统综述。搜索关键词包括“非手术治疗”、“骶脊索瘤”、“放疗”和“功能结果”。包括接受非手术治疗的骶脊索瘤患者的研究;手术治疗和混合治疗包括手术的患者被排除在分析之外。结果对52例35 ~ 85岁的骶脊索瘤患者进行非手术治疗的临床研究,平均62.8岁。男性受影响的比例高于女性(73.1% vs 26.9%)。S1(15.4%)和S2(25%)是受影响最大的脊柱节段。ct引导下活检是最常见的肿瘤诊断方法(82.7%)。碳离子放射治疗(CIRT)和质子束治疗是最常见的治疗方法,平均随访24个月,57.7%的患者报告无复发生存。结论非手术治疗骶脊索瘤对不需要手术治疗的患者有较好的疗效。虽然复发仍有风险,但非手术治疗可能提供有意义的功能保留和局部疾病控制。
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引用次数: 0
Injury patterns in footvolley players: an epidemiological survey 足球运动员的损伤模式:流行病学调查
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-01-08 DOI: 10.1016/j.jor.2025.12.066
Rodrigo Favarin Pozzobom , Tamiris Beppler Martins , Filippo Migliorini , Nicola Maffulli , Rodrigo Okubo

Background

Footvolley, a fusion of football and volleyball, has gained considerable popularity worldwide. The dynamic nature of the sport exposes players to various risks of injury. This study investigates the prevalence of injuries among footvolley athletes. It examines practitioner profiles and associated injuries and identifies the anatomical regions most commonly affected.

Material and methods

The study sample comprised footvolley players from Brazil, encompassing individuals of both genders aged 18 and above, with no restrictions on practice duration, to provide a comprehensive overview of player profiles within the sport. Data was collected using a customised form created in Google Forms®, which was disseminated via email, WhatsApp®, and social media platforms and distributed in training centres and to individual practitioners. The study population predominantly consisted of male participants, with an average age of 30.

Results

182 injuries were reported, resulting in an overall injury incidence rate of 1.43 per 1000 h of exposure. Notably, 52.3 % of practitioners experienced some form of injury related to footvolley practice. The anatomical segments most commonly affected were the knees, lumbar spine, neck, and ankles. Furthermore, the recurrence rate for all injuries was 21.5 %. Several factors were associated with a higher prevalence of injuries, including older age, increased experience and practice in footvolley, participation in competitions, and not engaging in simultaneous training in another modality.

Conclusions

This study sheds light on the injury landscape in footvolley and underscores the importance of implementing targeted injury prevention strategies and promoting athlete well-being in this dynamic sport.
足球是足球和排球的融合,在世界范围内获得了相当大的知名度。这项运动的动态性使运动员面临各种各样的受伤风险。本研究调查了足球运动员受伤的发生率。它检查从业者概况和相关的伤害,并确定最常受影响的解剖区域。材料和方法研究样本包括来自巴西的足球运动员,包括18岁及以上的男女球员,没有训练时间的限制,以提供运动员在这项运动中的全面概况。使用b谷歌Forms®中创建的定制表格收集数据,通过电子邮件、WhatsApp®和社交媒体平台传播,并在培训中心和个人从业者中分发。研究人群主要由男性参与者组成,平均年龄30岁。结果共报告182例损伤,总损伤发生率为1.43 / 1000 h。值得注意的是,52.3%的练习者经历过与足球练习有关的某种形式的伤害。最常受影响的解剖节段是膝关节、腰椎、颈部和脚踝。所有损伤的复发率为21.5%。有几个因素与较高的受伤发生率有关,包括年龄较大,足球经验和练习的增加,参加比赛,以及没有同时参加另一种形式的训练。结论:本研究揭示了足球运动的损伤情况,强调了在这项充满活力的运动中实施有针对性的损伤预防策略和促进运动员健康的重要性。
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引用次数: 0
Design-dependent associations between quadriceps strength and sagittal knee biomechanics after posterior-stabilized total knee arthroplasty: A 3D motion analysis study 后稳定全膝关节置换术后股四头肌力量和矢状膝关节生物力学之间的设计依赖关系:一项3D运动分析研究
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-01-07 DOI: 10.1016/j.jor.2026.01.005
Ryota Fujii , Hyunho Lee , Christopher Stickley , Kazuyoshi Nakanishi

Purpose

Single-radius (SR) and multi-radius (MR) femoral components are widely used in posterior-stabilized total knee arthroplasty (TKA). While previous studies have compared these designs primarily using clinical outcomes or basic kinematics, the relationship between quadriceps strength and dynamic sagittal-plane knee biomechanics remains insufficiently understood.

Methods

This prospective exploratory cohort study included 31 posterior-stabilized TKAs (SR: 16 knees; MR: 15 knees). Patients were evaluated at 6 months and 1 year postoperatively. Knee extension strength was measured using a handheld dynamometer. Sagittal-plane biomechanics during level walking, stair ascent, and stair descent were assessed using three-dimensional motion capture. External knee flexion moment (KFM) and KFM impulse were calculated. Associations between quadriceps strength and sagittal-plane biomechanical variables were analyzed using Spearman correlation coefficients.

Results

No significant between-group differences were observed in demographics or clinical activity levels. In the SR group, no significant associations were identified between quadriceps strength and sagittal-plane biomechanical variables at any postoperative time point. In contrast, the MR group demonstrated a moderate positive correlation between knee extensor strength and stair-descent knee flexion moment (KFM) impulse at 6 months postoperatively (r = 0.498, p < 0.05), which was not observed at 1 year postoperatively. During stair ascent, a significant positive correlation between knee extensor strength and the first peak KFM was observed in the MR group at 1 year (r = 0.606, p < 0.05).

Conclusions

This exploratory study demonstrated design-dependent associations between quadriceps strength and sagittal-plane knee biomechanics after posterior-stabilized TKA. While no significant between-group differences were observed in clinical or absolute biomechanical outcomes, task- and time-dependent strength–biomechanics associations were identified in the MR group, whereas no such associations were observed in the SR group, suggesting potential clinical relevance in patients with delayed quadriceps recovery.
目的单桡骨(SR)和多桡骨(MR)股骨假体广泛应用于后稳定全膝关节置换术(TKA)。虽然先前的研究主要通过临床结果或基本运动学来比较这些设计,但股四头肌力量和动态矢状面膝关节生物力学之间的关系仍然没有得到充分的了解。方法本前瞻性探索性队列研究纳入31例后稳定tka患者(SR: 16膝;MR: 15膝)。分别于术后6个月和1年对患者进行评估。使用手持式测力仪测量膝关节伸展强度。使用三维运动捕捉技术评估水平行走、楼梯上升和楼梯下降时的矢状面生物力学。计算膝关节外屈力矩(KFM)和KFM冲量。使用Spearman相关系数分析股四头肌力量与矢状面生物力学变量之间的关系。结果两组在人口统计学和临床活动水平上无显著差异。在SR组中,在任何术后时间点,股四头肌力量和矢状面生物力学变量之间没有明显的关联。相比之下,MR组在术后6个月时膝关节伸肌强度与下楼梯膝关节屈曲力矩(KFM)脉冲呈中度正相关(r = 0.498, p < 0.05),而在术后1年未观察到这种正相关。在爬楼梯过程中,MR组1年时膝关节伸肌强度与KFM第一次峰值呈显著正相关(r = 0.606, p < 0.05)。结论:本探索性研究证实了后稳定TKA后股四头肌力量与膝关节矢状面生物力学之间的设计依赖性关联。虽然在临床或绝对生物力学结果方面没有观察到组间的显著差异,但在MR组中发现了任务和时间依赖的力量-生物力学关联,而在SR组中没有观察到这种关联,这表明在股四头肌延迟恢复患者中存在潜在的临床相关性。
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引用次数: 0
METTL14 regulate LRIG1 expression via m6A to affect nucleus pulposus cell senescence in intervertebral disc degeneration METTL14通过m6A调控LRIG1表达,影响椎间盘退变中髓核细胞衰老
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-01-05 DOI: 10.1016/j.jor.2026.01.004
Ruihai Xiao , Qunying Yang , Yingqun Yin , Shanshan Peng , Xigao Cheng

Objectives

This study aims to explore the role of METTL14, a key m6A “writer” in regulating LRIG1 expression and its involvement in IVDD pathogenesis.

Methods

METTL14 expression was evaluated in nucleus pulposus (NP) tissues from IVDD patients at different degeneration stages using immunohistochemistry. In vitro experiments were conducted with METTL14 knockdown and TNF-α-induced cellular degeneration in NP cells. The effects on cellular senescence markers, ECM components, and m6A RNA methylation were examined. m6A RNA immunoprecipitation was employed to assess m6A modification levels. Bioinformatics tools predicted potential m6A sites on LRIG1 mRNA, which were further validated by luciferase reporter assays.

Results

METTL14 expression was significantly upregulated in NP tissues from patients with severe IVDD. METTL14 knockdown in NP cells led to reduced m6A enrichment on LRIG1 mRNA, destabilizing LRIG1 transcripts and increasing cellular senescence marker P21. TNF-α stimulation further induced METTL14 expression, exacerbated ECM degradation, and accelerated cellular senescence. Restoration of LRIG1 expression through overexpression mitigated the degenerative changes caused by METTL14 knockdown. Luciferase assays confirmed that METTL14 regulates LRIG1 mRNA stability via specific m6A sites, establishing a METTL14-LRIG1 axis in cellular senescence.

Conclusions

This study identifies METTL14 as a critical regulator of LRIG1-mediated ECM stability and cellular senescence in IVDD pathogenesis. The METTL14-LRIG1 axis, driven by m6A modifications, provides new mechanistic insights into the inflammatory and degenerative processes underlying IVDD. Targeting METTL14 or the associated m6A pathway may offer novel therapeutic strategies for IVDD.
目的探讨m6A关键“作者”METTL14在调控LRIG1表达及其参与IVDD发病机制中的作用。方法采用免疫组化方法检测不同退行性变阶段IVDD患者髓核(NP)组织中smettl14的表达。体外实验采用METTL14敲除和TNF-α-诱导NP细胞变性。研究了其对细胞衰老标志物、ECM成分和m6A RNA甲基化的影响。m6A RNA免疫沉淀法评估m6A修饰水平。生物信息学工具预测了LRIG1 mRNA上潜在的m6A位点,并通过荧光素酶报告基因试验进一步验证了这一预测。结果重度IVDD患者NP组织中mettl14表达明显上调。NP细胞中METTL14敲低导致LRIG1 mRNA上m6A富集减少,LRIG1转录物不稳定,细胞衰老标志物P21增加。TNF-α刺激进一步诱导METTL14表达,加剧ECM降解,加速细胞衰老。通过过表达恢复LRIG1的表达可以减轻METTL14敲低引起的退行性变化。荧光素酶测定证实,METTL14通过特定的m6A位点调节LRIG1 mRNA的稳定性,在细胞衰老过程中建立了METTL14-LRIG1轴。结论本研究确定METTL14在IVDD发病过程中是lrig1介导的ECM稳定性和细胞衰老的关键调节因子。由m6A修饰驱动的METTL14-LRIG1轴为IVDD的炎症和退行性过程提供了新的机制见解。靶向METTL14或相关的m6A通路可能为IVDD提供新的治疗策略。
{"title":"METTL14 regulate LRIG1 expression via m6A to affect nucleus pulposus cell senescence in intervertebral disc degeneration","authors":"Ruihai Xiao ,&nbsp;Qunying Yang ,&nbsp;Yingqun Yin ,&nbsp;Shanshan Peng ,&nbsp;Xigao Cheng","doi":"10.1016/j.jor.2026.01.004","DOIUrl":"10.1016/j.jor.2026.01.004","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to explore the role of METTL14, a key m6A “writer” in regulating LRIG1 expression and its involvement in IVDD pathogenesis.</div></div><div><h3>Methods</h3><div>METTL14 expression was evaluated in nucleus pulposus (NP) tissues from IVDD patients at different degeneration stages using immunohistochemistry. In vitro experiments were conducted with METTL14 knockdown and TNF-α-induced cellular degeneration in NP cells. The effects on cellular senescence markers, ECM components, and m6A RNA methylation were examined. m6A RNA immunoprecipitation was employed to assess m6A modification levels. Bioinformatics tools predicted potential m6A sites on LRIG1 mRNA, which were further validated by luciferase reporter assays.</div></div><div><h3>Results</h3><div>METTL14 expression was significantly upregulated in NP tissues from patients with severe IVDD. METTL14 knockdown in NP cells led to reduced m6A enrichment on LRIG1 mRNA, destabilizing LRIG1 transcripts and increasing cellular senescence marker P21. TNF-α stimulation further induced METTL14 expression, exacerbated ECM degradation, and accelerated cellular senescence. Restoration of LRIG1 expression through overexpression mitigated the degenerative changes caused by METTL14 knockdown. Luciferase assays confirmed that METTL14 regulates LRIG1 mRNA stability via specific m6A sites, establishing a METTL14-LRIG1 axis in cellular senescence.</div></div><div><h3>Conclusions</h3><div>This study identifies METTL14 as a critical regulator of LRIG1-mediated ECM stability and cellular senescence in IVDD pathogenesis. The METTL14-LRIG1 axis, driven by m6A modifications, provides new mechanistic insights into the inflammatory and degenerative processes underlying IVDD. Targeting METTL14 or the associated m6A pathway may offer novel therapeutic strategies for IVDD.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"74 ","pages":"Pages 195-204"},"PeriodicalIF":1.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Legal blindness as a risk factor for complications and prolonged hospitalization after spinal fusion 法定失明是脊柱融合术后并发症和延长住院时间的危险因素
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-01-03 DOI: 10.1016/j.jor.2026.01.001
Donald MacElroy , Jay B. Ayar , Samir Rao , Merritt D. Kinon

Introduction

Legally blind patients represent a vulnerable group who may face barriers to safe mobility, postoperative rehabilitation, and discharge planning. There is limited evidence describing perioperative course during spinal fusion surgery in this population. This study aimed to evaluate the association between legal blindness, operative complications and discharge disposition in patients undergoing cervical or lumbar spinal fusion.

Methods

The National Inpatient Sample was queried from 2016 to 2021, identifying adult hospitalizations for cervical or lumbar spinal fusion using ICD-10 procedure codes. The primary exposure was legal blindness (ICD-10-CM: H54.8). Outcomes included: major medical complications, non-home discharge and extended length of stay (>3 days). Survey-weighted logistic regression was used to evaluate associations between legal blindness and complications.

Results

Among 338,578 hospitalizations for cervical or lumbar spinal fusion that met our inclusion criteria, 315 involved legally blind patients. In multivariate analysis adjusting for demographics, comorbidities and hospital level covariates, legal blindness was independently associated with higher odds of major medical complications (aOR 1.58, 95 % CI 1.08–2.32), non-home discharge (aOR 2.57, 95 % CI 1.98–3.32), and extended length of stay (aOR 1.67, 95 % CI 1.31–2.12).

Conclusions

Legal blindness is independently associated with increased major medical complications, extended hospital stays and higher rates of non-home discharge following spinal fusion procedures. These findings highlight the importance of recognizing visual impairment as a marker of perioperative vulnerability in the context of spinal fusion surgery and highlight the need for targeted perioperative strategies to support this underrepresented population.
法定失明患者是一个弱势群体,他们可能面临安全行动、术后康复和出院计划方面的障碍。在这一人群中,描述脊柱融合术围手术期病程的证据有限。本研究旨在评估接受颈椎或腰椎融合术患者的法定失明、手术并发症和出院处置之间的关系。方法查询2016年至2021年全国住院患者样本,使用ICD-10程序代码确定颈椎或腰椎融合术的成人住院病例。主要暴露为法定失明(ICD-10-CM: H54.8)。结果包括:主要医疗并发症、非居家出院和延长住院时间(3天)。采用调查加权logistic回归来评估法律盲症与并发症之间的关系。结果在338,578例符合纳入标准的颈椎或腰椎融合术住院患者中,315例为法定盲患者。在调整人口统计学、合并症和医院水平协变量的多变量分析中,法定失明与较高的主要医疗并发症(aOR 1.58, 95% CI 1.08-2.32)、非居家出院(aOR 2.57, 95% CI 1.98-3.32)和延长住院时间(aOR 1.67, 95% CI 1.31-2.12)独立相关。结论:法定失明与脊柱融合术后主要并发症增加、住院时间延长和非家庭出院率升高独立相关。这些发现强调了在脊柱融合手术背景下,将视力障碍作为围手术期易损标志的重要性,并强调了有针对性的围手术期策略的必要性,以支持这一未被充分代表的人群。
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引用次数: 0
A decade of progress and paradigm shifts in osteoporosis therapeutics: A bibliometric analysis 十年来骨质疏松症治疗的进展和范式转变:文献计量学分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-31 DOI: 10.1016/j.jor.2025.12.069
Yanping Liu, Xijie Yu
Despite extensive research on osteoporosis therapies, systematic analysis of knowledge evolution and translational bottlenecks remains unexplored. This study presents the multidimensional bibliometric analysis of 10,247 publications (2015–2024) to decode paradigm shifts in osteoporosis therapeutics. Using CiteSpace and VOSviewer for bibliometric and visualization analyses, we observed a notable increase in annual publications, peaking in 2022. China and the United States led in research output, while European countries demonstrated higher citation impact. Shanghai Jiao Tong University, Harvard Medical School, and Chinese Academy of Sciences were the top three contributing institutions. Cooper, Cyrus is the most influential author. In academic publishing, Osteoporosis International has been identified as the journal with the most research results in the field of osteoporosis treatment. Keyword emergence analysis revealed a transition in research focus from randomized controlled trial and ovariectomized rats to drug, discontinuation, osteogenesis, bisphosphonate related osteonecrosis, network pharmacology, molecular docking, reduction, fixation, damage, American association, osteoporotic fracture, gut microbiota in the last five years, and that this is being explored in detail for future work. In summary, this study offers a thorough bibliometric analysis of osteoporosis therapeutics worldwide, providing scholars conducting analogous research in this field with valuable insights.
尽管对骨质疏松症治疗进行了广泛的研究,但对知识演变和转化瓶颈的系统分析仍未得到探索。本研究对10247份出版物(2015-2024)进行多维文献计量分析,以解读骨质疏松症治疗的范式转变。使用CiteSpace和VOSviewer进行文献计量和可视化分析,我们观察到年度出版物显著增加,并在2022年达到峰值。中国和美国在研究产出方面处于领先地位,而欧洲国家表现出更高的引用影响力。上海交通大学、哈佛医学院和中国科学院是贡献最大的三个机构。库珀,塞勒斯是最有影响力的作家。在学术出版方面,《骨质疏松国际》被认为是骨质疏松治疗领域研究成果最多的期刊。关键词涌现分析揭示了近五年来研究重点从随机对照试验和去卵巢大鼠向药物、停药、成骨、双膦酸盐相关骨坏死、网络药理学、分子对接、复位、固定、损伤、美国关联、骨质疏松性骨折、肠道微生物群的转变,并为今后的工作提供了详细的探讨。综上所述,本研究对全球骨质疏松治疗方法进行了全面的文献计量分析,为在该领域进行类似研究的学者提供了有价值的见解。
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引用次数: 0
Association of surgical procedure and radiographic hip alignment with hip abductor strength ratio at discharge after proximal femoral fracture surgery 股骨近端骨折术后出院时髋外展肌力量比与手术方式和髋关节x线对准的关系
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-31 DOI: 10.1016/j.jor.2025.12.068
Satoshi Hakukawa, Shunsuke Onuma, Kanata Yoshihara

Background

Hip abductor weakness is common after proximal femoral fracture and may contribute to gait instability. The influence of postoperative hip alignment on early recovery of hip abductor strength during inpatient rehabilitation after surgery remains unclear.

Objective

To examine longitudinal changes in hip abductor strength and identify factors associated with the operated-to-non-operated hip abductor strength ratio at discharge, focusing on surgical procedure and radiographic alignment.

Methods

This retrospective observational cohort study enrolled 64 patients transferred to a rehabilitation hospital after proximal femoral fracture surgery (34 femoral neck fractures treated with hemiarthroplasty; 30 intertrochanteric fractures treated with cephalomedullary nailing). Hip abductor strength was measured using a handheld dynamometer at rehabilitation admission and discharge and normalized by body weight. Radiographic parameters were measured on supine anteroposterior pelvic radiographs; side-to-side differences (operated minus non-operated) were calculated for the neck–shaft angle, hip center of rotation, femoral offset, and trochanteric height. Multivariable linear regression (ANCOVA-type) was performed with the discharge strength ratio as the dependent variable and the admission strength ratio as an adjustment factor.

Results

Hip abductor strength improved on both sides (p < 0.001). The operated side increased from 1.04 ± 0.5 to 1.8 ± 0.7 N/kg and the non-operated side from 1.6 ± 0.6 to 2.3 ± 0.8 N/kg; the operated-to-non-operated ratio improved from 62.7 % to 72.9 %. In the adjusted model (R2 = 0.325), cephalomedullary nailing (vs hemiarthroplasty) was associated with a higher discharge strength ratio (B = 0.114, p = 0.027). A greater neck–shaft angle difference was also associated with a higher discharge strength ratio (B = 0.0073 per degree, p = 0.011). The admission strength ratio remained a significant predictor (B = 0.245, p = 0.002).

Conclusions

Early recovery of the hip abductor strength ratio after proximal femoral fracture was associated with surgical procedure and postoperative neck–shaft angle asymmetry, independent of baseline strength ratio. Postoperative radiographic alignment may aid in stratifying recovery and tailoring rehabilitation, although causal inference is limited.
背景:股骨近端骨折后髋关节外展肌无力很常见,可能导致步态不稳定。术后髋关节对准对术后住院康复期间髋关节外展肌力早期恢复的影响尚不清楚。目的探讨髋关节外展肌力量的纵向变化,并确定与出院时手术与非手术髋关节外展肌力量比相关的因素,重点是手术方式和x线对准。方法回顾性观察队列研究纳入64例股骨近端骨折术后转至康复医院的患者,其中34例股骨颈骨折采用半关节置换术治疗,30例股骨粗隆间骨折采用头髓内钉治疗。在康复入院和出院时使用手持式测力仪测量髋关节外展肌力,并按体重归一化。在仰卧位骨盆正位x线片上测量影像学参数;计算颈轴角、髋关节旋转中心、股骨偏移量和粗隆高度的侧对侧差异(手术减去非手术)。以出料强度比为因变量,进料强度比为调节因子,进行ancova型多变量线性回归分析。结果双侧外展肌力量均有改善(p < 0.001)。手术侧从1.04±0.5 N/kg增加到1.8±0.7 N/kg,非手术侧从1.6±0.6 N/kg增加到2.3±0.8 N/kg;运行与非运行比率从62.7%提高到72.9%。在调整后的模型中(R2 = 0.325),头髓内钉(与半关节置换术相比)与较高的出院强度比相关(B = 0.114, p = 0.027)。较大的颈轴角差也与较高的放电强度比相关(B = 0.0073 /度,p = 0.011)。入院强度比仍然是一个显著的预测因子(B = 0.245, p = 0.002)。结论股骨近端骨折后髋外展肌力量比的早期恢复与手术方式和术后颈轴角不对称有关,与基线力量比无关。术后x线对准可能有助于分层恢复和定制康复,尽管因果推理有限。
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引用次数: 0
Risk factors for mortality in patients following total hip arthroplasty and hemiarthroplasty due to femoral neck fractures 股骨颈骨折患者全髋关节置换术和半髋关节置换术后死亡率的危险因素
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-31 DOI: 10.1016/j.jor.2025.12.067
Itay Ron , Lizi Tamam , Bezalel Peskin , Nabil Ghrayeb , Doron Norman , Jacob Shapira

Background

Femoral neck fractures (FNF) in older adults are frequently managed with either total hip arthroplasty (THA) or hemiarthroplasty (HA). Despite improvements in surgical techniques, mortality rates after hip fracture surgery remain high. Identifying predictors of early mortality may enhance surgical decision-making, optimize perioperative management, and improve patient outcomes.

Purpose

The purpose of this study was to determine the short- and mid-term mortality rates after THA and HA for FNF, to identify clinical, demographic, and laboratory factors associated with 30-, 90-, and 180-day mortality, and to establish clinically relevant cutoff thresholds for significant continuous variables to stratify risk.

Patients and methods

We retrospectively reviewed 2379 consecutive patients treated for sub-capital FNF at a tertiary trauma center between [insert study years]. Of these, 831 underwent THA and 1548 underwent HA. Mortality was assessed at 30, 90, and 180 days postoperatively. Demographic, clinical, and laboratory parameters were analyzed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curve analysis was performed to identify optimal cutoff thresholds for significant continuous predictors.

Results

Among THA patients, mortality was 1.4 % at 30 days, 3.4 % at 90 days, and 5.1 % at 180 days. Postoperative albumin ≤2.85 g/dL predicted 30-day mortality, while C-reactive protein (CRP) > 19.15 mg/dL was independently associated with mortality at 90 and 180 days. Among HA patients, mortality was 6.6 % at 30 days, 12.9 % at 90 days, and 17.6 % at 180 days. Predictors of 30-day mortality included white blood cell count (WBC) > 14.48 × 109/L, albumin <3.55 g/dL, and Charlson Comorbidity Index (CCI) > 7.5. At 90 and 180 days, age >83.65 and > 89.34 years, WBC >13.49 × 109/L, albumin <3.35–3.45 g/dL, creatinine >1.08 mg/dL, and CCI >6.5 were associated with higher mortality risk.

Conclusions

This study identified several laboratory and clinical markers that predict short- and mid-term mortality following hip arthroplasty for FNF. Hypoalbuminemia, elevated inflammatory markers, renal dysfunction, and high comorbidity burden were consistent risk factors. Incorporating these parameters into preoperative assessment may improve patient selection, perioperative optimization, and shared decision-making.

Level of Evidence

III
背景:老年人股骨颈骨折(FNF)通常采用全髋关节置换术(THA)或半髋关节置换术(HA)治疗。尽管手术技术有所进步,髋部骨折手术后的死亡率仍然很高。确定早期死亡的预测因素可以加强手术决策,优化围手术期管理,改善患者预后。目的本研究的目的是确定全髋关节置换术和全髋关节置换术后FNF的短期和中期死亡率,确定与30天、90天和180天死亡率相关的临床、人口统计学和实验室因素,并为重要的连续变量建立临床相关的临界值,以对风险进行分层。患者和方法我们回顾性回顾了2379例连续在三级创伤中心接受亚资本FNF治疗的患者。其中831例行THA, 1548例行HA。分别于术后30、90和180天评估死亡率。使用单变量和多变量logistic回归模型分析人口统计学、临床和实验室参数。进行受试者工作特征(ROC)曲线分析,以确定显著连续预测因子的最佳截止阈值。结果THA患者30天死亡率为1.4%,90天死亡率为3.4%,180天死亡率为5.1%。术后白蛋白≤2.85 g/dL预测30天死亡率,而c反应蛋白(CRP)≤19.15 mg/dL与90天和180天死亡率独立相关。在HA患者中,30天死亡率为6.6%,90天死亡率为12.9%,180天死亡率为17.6%。预测30天死亡率的指标包括白细胞计数(WBC) 14.48 × 109/L、白蛋白3.55 g/dL和Charlson合并症指数(CCI) 7.5。90日龄和180日龄、83.65岁和89.34岁、WBC 13.49 × 109/L、白蛋白3.35 ~ 3.45 g/dL、肌酐1.08 mg/dL、CCI 6.5与较高的死亡风险相关。结论:本研究确定了几个实验室和临床指标,可预测FNF髋关节置换术后的短期和中期死亡率。低白蛋白血症、炎症标志物升高、肾功能不全和高合并症负担是一致的危险因素。将这些参数纳入术前评估可以改善患者选择、围手术期优化和共同决策。证据水平ⅱ
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引用次数: 0
A systematic review and meta-analysis of cases of prosthetic hip-associated cobalt toxicity in patients with prosthetic hip ceramic bearing fractures subsequently revised to metal-on-polyethylene implants 一项系统回顾和荟萃分析,在髋关节陶瓷骨折患者中,随后修改为金属对聚乙烯植入物的假髋关节相关钴毒性病例
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-31 DOI: 10.1016/j.jor.2025.12.064
Patrick Sweeney , James Broderick

Background

Prosthetic hip-associated cobalt toxicity (PHACT) remains a rare but serious complication, potentially leading to missed diagnoses and delayed treatment. This systematic review explores cases of PHACT associated with fractured ceramic bearing followed by revision surgery with metal-on-polyethylene implants. Notably, patients in this subgroup often exhibited earlier symptom onset and elevated cobalt ion levels. Through a systematic review, we aim to explore and summarise the most common symptoms and clinical outcomes associated with PHACT among this specific patient subgroup. Our focus is on identifying patterns of systemic symptoms and associated clinical outcomes.

Methods

Adhering to PRISMA guidelines, we conducted a structured search across PubMed, Medline, and Scopus databases. Inclusion criteria comprised published case reports or case series detailing PHACT cases after ceramic bearing fractures revised to metal-on-polyethylene bearings. Over 30 cases were identified, and their clinical presentations and outcomes were analysed.

Result

The majority of PHACT cases in this cohort presented with cardiovascular manifestations (cardiomyopathy, cardiogenic shock, and heart failure), neurological symptoms (visual impairment, sensorineural hearing loss, and cognitive impairment), and endocrine dysfunction (thyroid dysfunction). Various atypical symptoms were also observed.

Conclusion

PHACT within this patient group presents insidiously with diverse, sometimes overlapping, systemic symptoms. The study highlights the potential for missed diagnoses due to the lack of apparent risk factors or related medical history. This review strongly advocates for proactive, registry data-driven identification of at-risk patients, as well as the opportunity for follow-up assessment and cobalt level monitoring. This study also highlights the importance of ceramic-on-polyethylene based revision in cases of ceramic bearing fractures.
假体髋关节相关钴毒性(PHACT)仍然是一种罕见但严重的并发症,可能导致漏诊和延迟治疗。本系统综述探讨了PHACT与陶瓷轴承骨折相关的病例,随后使用金属对聚乙烯植入物进行翻修手术。值得注意的是,该亚组患者通常表现出较早的症状发作和钴离子水平升高。通过系统回顾,我们旨在探索和总结这一特定患者亚组中与PHACT相关的最常见症状和临床结果。我们的重点是识别全身性症状的模式和相关的临床结果。方法遵循PRISMA指南,在PubMed、Medline和Scopus数据库中进行结构化检索。纳入标准包括已发表的病例报告或病例系列,详细介绍了陶瓷轴承骨折后的PHACT病例,修订为金属对聚乙烯轴承。我们对30多例病例进行了临床分析。结果该队列中大多数PHACT病例表现为心血管症状(心肌病、心源性休克和心力衰竭)、神经系统症状(视力障碍、感音神经性听力损失和认知障碍)和内分泌功能障碍(甲状腺功能障碍)。还观察到各种不典型症状。结论该患者组的phact隐匿地表现为多样的,有时重叠的全身性症状。该研究强调了由于缺乏明显的危险因素或相关病史而漏诊的可能性。本综述强烈主张积极主动、注册数据驱动的高危患者识别,并有机会进行随访评估和钴水平监测。该研究还强调了陶瓷-聚乙烯基修复在陶瓷轴承骨折病例中的重要性。
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引用次数: 0
期刊
Journal of orthopaedics
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