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mModPoEs: Multimodal posture estimation and feedback-driven correction of load-bearing human movements using wearable sensors and computer vision mModPoEs:使用可穿戴传感器和计算机视觉对负重人体运动进行多模态姿态估计和反馈驱动校正
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-12 DOI: 10.1016/j.jor.2025.12.024
P. Gokul Thilaak , G. Malathi , D. Thiagarajan

Objective

Improper spinal posture during activities of daily living such as seated posture, upright stance, and ambulation, particularly under load-bearing conditions, has been recognized as a major contributor to musculoskeletal disorders, including chronic back pain and disc degeneration. This study presents a multimodal posture estimation and feedback framework that integrates wearable-sensor data and computer-vision analysis to support spinal health.

Methods

The system integrates data from Inertial Measurement Units (IMUs) and flex sensors to quantify postural angles which acts as sensor data, while concurrently extracting key visual features from multi-view (frontal and lateral) video recordings and photographs using the MediaPipe framework. A control group was formed under the guidance of physiotherapist and the data was collected at Tagore College of Physiotherapy located in Chennai, India. This control group comprises of 40 subjects, selected without gender bias, aged between 19 and 22 years. The analysis on multimodal data incorporated specifically, logistic regression (LR), decision tree (DT), random forest (RF), KNN and SVM.

Results

Among all evaluated models, the RF algorithm, showed effective performance and balance in all activities of both male and female subjects. The dataset used was a composite collection of both genders, resulting in accuracy rates of 75 %, 95 % and 63 % for sitting, standing, and walking, respectively.

Conclusion

The findings highlight that integrating wearable and visual modalities enhances posture classification accuracy. While the findings are preliminary, they establish a methodological foundation for future development of multimodal, feedback-based posture assessment systems.
在日常生活活动中,如坐姿、直立站立和行走时,特别是在负重条件下,不正确的脊柱姿势已被认为是肌肉骨骼疾病(包括慢性背痛和椎间盘退变)的主要原因。本研究提出了一个多模态姿势估计和反馈框架,该框架集成了可穿戴传感器数据和计算机视觉分析,以支持脊柱健康。方法该系统集成了惯性测量单元(imu)和弯曲传感器的数据,量化姿态角度作为传感器数据,同时使用MediaPipe框架从多视角(正面和侧面)视频记录和照片中提取关键视觉特征。在物理治疗师的指导下组成对照组,数据收集于印度金奈泰戈尔物理治疗学院。该对照组包括40名受试者,年龄在19至22岁之间,无性别偏见。对多模态数据的分析包括逻辑回归(LR)、决策树(DT)、随机森林(RF)、KNN和支持向量机(SVM)。结果在所有评估模型中,RF算法在男性和女性受试者的所有活动中都表现出有效的性能和平衡。使用的数据集是两种性别的合成集合,坐姿、站立和行走的准确率分别为75%、95%和63%。结论结合可穿戴和视觉模式可提高姿势分类的准确性。虽然这些发现是初步的,但它们为未来多模式、基于反馈的姿势评估系统的发展奠定了方法学基础。
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引用次数: 0
Femoral neck system vs conventional fixation: Long-term outcomes from a single-center study 股骨颈系统与传统固定:单中心研究的长期结果
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-11 DOI: 10.1016/j.jor.2025.12.021
Grégoire Châtelier , Romain Huguet , Igor Benezis , Johan Lebecque

Background

The Femoral Neck System (FNS) is a minimally invasive fixation device for femoral neck fractures, but its comparative long-term performance versus conventional fixation remains debated.

Materials and methods

In this single-center retrospective study (Jan 2020–Oct 2022) all patients treated surgically for femoral neck fractures were included. Primary outcomes were operative time, peri-operative bleeding, fixation failure, avascular necrosis, reoperation, mortality, and autonomy using Parker score. A multivariable logistic regression assessed risk of postoperative loss of autonomy. FNS results were compared to a large multicenter series from the literature.

Resultsa

total of 143 patients (mean age 78.7 ± 13.8 years; 58.7 % women) were included and grouped by implant: 31 FNS, 62 triple cannulated screws, 50 dynamic hip screw (DHS). Operative time differed across groups with DHS being the longest. Peri-operative bleeding, fixation failure, infection, and mortality did not differ significantly between groups. In adjusted analysis, each additional year of age increased the risk of postoperative loss of autonomy by 5.1 % independently of the surgical system. Mean follow-up was approximately two years enabling detection of later complications.

Conclusion

FNS provided outcomes broadly comparable to conventional fixation with shorter operative time than DHS. Given the older, more displaced case-mix and longer follow-up, cautious interpretation is warranted. Age emerged as the strongest predictor of functional outcome.
股骨颈系统(FNS)是一种用于股骨颈骨折的微创固定装置,但其与传统固定装置的长期性能比较仍存在争议。材料与方法本研究为单中心回顾性研究(2020年1月- 2022年10月),纳入所有股骨颈骨折手术治疗的患者。主要结局是手术时间、围术期出血、固定失败、缺血性坏死、再手术、死亡率和使用帕克评分的自主性。多变量logistic回归评估术后自主性丧失的风险。将FNS结果与文献中的大型多中心序列进行比较。结果共纳入143例患者(平均年龄78.7±13.8岁,女性58.7%),按植入物分类:FNS 31例,三空心螺钉62例,动态髋螺钉(DHS) 50例。各组手术时间不同,DHS最长。围手术期出血、固定失败、感染和死亡率在两组间无显著差异。在调整后的分析中,年龄每增加一岁,与手术系统无关的术后自主性丧失风险增加5.1%。平均随访时间约为两年,可发现后期并发症。结论fns的疗效与传统固定大体相当,手术时间比DHS短。鉴于较早、更分散的病例组合和较长的随访时间,有必要谨慎解释。年龄是功能预后的最强预测因子。
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引用次数: 0
The management of proximal periprosthetic femoral fractures: Is open reduction and internal fixation a solution for all fractures treated surgically around a polished tapered stem? 股骨近端假体周围骨折的治疗:切开复位和内固定是所有手术治疗的方法吗?
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-11 DOI: 10.1016/j.jor.2025.12.009
Emily Seymour-Jackson , Rohan Ramasubbu , James Doonan , Kevin Bryceland , Andrew Stark

Aims & objectives

The aim of this study is to assess whether open reduction and internal fixation (ORIF) is appropriate for the surgical management of all proximal femoral periprosthetic fractures involving a polished tapered stem.

Methods

This retrospective case series assessed the five year follow-up of 105 consecutive patients treated with ORIF following proximal femoral periprosthetic fractures with minimum 12-month follow-up. Primary outcome measure of this study was union at one year following surgery and secondary outcome measures included reoperation, post-operative infection and dislocation.

Results

105 patients had periprosthetic fractures over 10 years (B1 n = 31; B2 n = 64; and C n = 10). Union within one year of periprosthetic fractures were achieved in 76.7 % of short oblique/transverse fractures and 100 % of long spiral fractures. The fracture pattern and fracture location with B1, B2 and C type were disturbed in a statistically significant pattern. Importantly, each periprosthetic fractures that did not achieve union by one year resulted in plate breakage which resulted in further major revision surgery.

Conclusions

We advocate that ORIF should be attempted in all proximal femoral periprosthetic fractures as only a small number of patients develop non-union and go on to require further surgery. Short oblique fractures at the tip of the stem are higher risk for non-union and dual plating could be considered in these cases.
目的:本研究的目的是评估切开复位内固定(ORIF)是否适用于所有股骨近端涉及磨光锥形柄的假体周围骨折的手术治疗。方法回顾性分析105例股骨近端假体周围骨折患者连续5年的随访情况,随访时间至少为12个月。本研究的主要指标是术后1年愈合,次要指标包括再手术、术后感染和脱位。结果10年内发生假体周围骨折105例(B1 31例,B2 64例,C 10例)。76.7%的短斜/横骨折和100%的长螺旋骨折在一年内愈合。B1型、B2型和C型的骨折形态和骨折位置有统计学意义的干扰。重要的是,每个假体周围骨折在一年内未愈合导致钢板断裂,导致进一步的大翻修手术。结论:我们提倡在所有股骨近端假体周围骨折中尝试ORIF,因为只有少数患者出现不愈合并需要进一步手术。椎弓根尖端短斜骨折发生骨不愈合的风险较高,在这种情况下可考虑采用双钢板。
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引用次数: 0
Novel hematological indices SII and NLR: Aiding diagnosis, differentiating subtypes, and reflecting disease activity in juvenile idiopathic arthritis 新的血液学指标SII和NLR:帮助诊断、区分亚型和反映青少年特发性关节炎的疾病活动性
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-10 DOI: 10.1016/j.jor.2025.12.014
XiaoLin Luo , JianWei Hu , ShengPing Tang , ChenYang Li , ShiJie Liao , XiaoFei Ding

Objective

This study aimed to evaluate the clinical utility of novel hematological indices, particularly the systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) in diagnosing juvenile idiopathic arthritis (JIA), differentiating its subtypes, and assessing disease activity.

Methods

We conducted a retrospective analysis of 185 JIA patients and 124 healthy controls. Comprehensive clinical and hematological parameters were collected, and immune-inflammatory ratios were calculated. Participants were stratified by JIA subtype according to ILAR criteria and by disease activity based on Wallace criteria. Statistical analyses compared these indices across groups and evaluated their correlations with conventional markers and the JADAS-27 score. Subgroup analyses further assessed their diagnostic potential in patients with normal erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP).

Results

SII, NLR, platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were significantly elevated in JIA patients compared to controls, with AUC values > 0.6 for JIA identification. Notably, systemic JIA (sJIA) showed distinct inflammatory profiles, with significantly higher SII, MLR, PLR, and NLR, and lower monocyte-to-neutrophil ratio (MNR) and platelet-to-neutrophil ratio (PNR), compared to other subtypes. Active JIA patients exhibited elevated SII and NLR and reduced MNR relative to those with inactive disease. SII and NLR demonstrated moderate positive correlations with ESR, CRP, and JADAS-27, whereas MNR was negatively correlated. Although subgroup analyses in patients with normal ESR/CRP did not reach statistical significance, likely due to sample size limitations—the consistent trends support the potential supplementary role of these indices.

Conclusion

This study establishes SII and NLR as accessible and informative biomarkers for JIA. They effectively differentiate systemic JIA from other subtypes, reflect disease activity, and correlate with established activity scores. Their low cost and routine availability position them as valuable adjuncts in the diagnostic and monitoring workflow for JIA, particularly when traditional markers are ambiguous or unavailable.
目的评价新型血液学指标,特别是全身免疫炎症指数(SII)和中性粒细胞与淋巴细胞比值(NLR)在诊断幼年特发性关节炎(JIA)、区分其亚型和评估疾病活动性中的临床应用价值。方法对185例JIA患者和124例健康对照进行回顾性分析。收集综合临床和血液学参数,计算免疫炎症比。根据ILAR标准按JIA亚型和Wallace标准按疾病活动度对参与者进行分层。统计分析比较各组的这些指标,并评估它们与常规标记物和JADAS-27评分的相关性。亚组分析进一步评估了它们在正常红细胞沉降率(ESR)/ c反应蛋白(CRP)患者中的诊断潜力。结果JIA患者sii、NLR、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)较对照组显著升高,鉴别JIA的AUC值为0.6。值得注意的是,系统性JIA (sJIA)表现出明显的炎症特征,与其他亚型相比,SII、MLR、PLR和NLR明显较高,单核细胞与中性粒细胞比率(MNR)和血小板与中性粒细胞比率(PNR)较低。与非活动性JIA患者相比,活动性JIA患者SII和NLR升高,MNR降低。SII和NLR与ESR、CRP和JADAS-27呈中度正相关,而MNR呈负相关。虽然正常ESR/CRP患者的亚组分析没有达到统计学意义,可能是由于样本量的限制,但一致的趋势支持这些指标的潜在补充作用。结论本研究确立了SII和NLR是JIA的可及和信息丰富的生物标志物。它们能有效区分系统性JIA与其他亚型,反映疾病活动性,并与已建立的活动性评分相关。它们的低成本和常规可用性使它们成为JIA诊断和监测工作流程中有价值的辅助工具,特别是当传统标记物不明确或不可用时。
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引用次数: 0
Greening orthopaedic surgery: Carbon footprint, waste generation, environmental impact, and mitigation strategies 绿化骨科手术:碳足迹、废物产生、环境影响和缓解策略
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-10 DOI: 10.1016/j.jor.2025.12.018
Anil Regmi , Surakshya Baral , Abdus Sami , Vijay Kumar Jain

Background

Orthopaedic surgery is among the most resource-intensive areas of healthcare, generating substantial waste, energy consumption, and carbon emissions. Operating rooms contribute disproportionately to a hospital's environmental footprint due to their high energy loads, extensive use of consumables, and complex supply chains. Despite rising global attention to sustainable healthcare, evidence specific to orthopaedic practice remains fragmented.

Objectives

This narrative review synthesises current evidence on the environmental impact of orthopaedic surgery, identifies major contributors to waste and carbon footprint, and outlines effective mitigation strategies applicable at institutional, clinical, and policy levels.

Methods

A structured search was conducted using MeSH and keyword combinations related to carbon footprint, sustainability, and orthopaedic surgery. Eligible studies included original research, reviews, and institutional reports assessing waste generation, CO2e emissions, energy use, or sustainability interventions. Two reviewers independently screened studies and performed thematic synthesis.

Results

Orthopaedic procedures generate 4–10 kg of waste per case, with plastics comprising nearly half. Life-cycle assessments report procedure-level emissions ranging from 28 to >150 kg CO2e, highest in arthroplasty and spine surgery. Major footprint contributors include OR energy use, single-use consumables, implant manufacturing, sterilisation, and anaesthetic gases. Evidence demonstrates that tray optimisation, reusable systems, improved waste segregation, low-flow anaesthesia, and environmentally preferable procurement can reduce environmental impact by 20–70 %. However, methodological heterogeneity and limited data from low-income settings hinder the benchmarking process.

Conclusion

Orthopaedic surgery carries a significant environmental burden; however, multiple evidence-based strategies can substantially reduce its environmental footprint. Standardised assessment methods and broader global data are essential to guide sustainable surgical practice.
骨科手术是医疗保健中资源最密集的领域之一,产生大量的废物、能源消耗和碳排放。由于手术室的高能耗负荷、耗材的广泛使用和复杂的供应链,手术室对医院的环境足迹造成了不成比例的影响。尽管全球越来越关注可持续医疗保健,但具体到骨科实践的证据仍然是碎片化的。本综述综合了骨科手术对环境影响的现有证据,确定了造成废物和碳足迹的主要因素,并概述了适用于机构、临床和政策层面的有效缓解策略。方法采用MeSH和碳足迹、可持续性、骨科相关关键词组合进行结构化检索。合格的研究包括评估废物产生、二氧化碳排放、能源使用或可持续性干预措施的原始研究、评论和机构报告。两位审稿人独立筛选研究并进行主题综合。结果整形手术每个病例产生4-10公斤的废物,其中塑料占近一半。生命周期评估报告的手术水平排放范围为28至150公斤二氧化碳当量,在关节置换术和脊柱手术中最高。主要的足迹贡献者包括手术室能源使用、一次性耗材、植入物制造、消毒和麻醉气体。有证据表明,托盘优化、可重复使用的系统、改进的废物分类、低流量麻醉和环保采购可以减少20 - 70%的环境影响。然而,方法的异质性和来自低收入环境的有限数据阻碍了对标过程。结论骨科手术具有明显的环境负担;然而,多种基于证据的策略可以大大减少其环境足迹。标准化的评估方法和更广泛的全球数据对于指导可持续的外科实践至关重要。
{"title":"Greening orthopaedic surgery: Carbon footprint, waste generation, environmental impact, and mitigation strategies","authors":"Anil Regmi ,&nbsp;Surakshya Baral ,&nbsp;Abdus Sami ,&nbsp;Vijay Kumar Jain","doi":"10.1016/j.jor.2025.12.018","DOIUrl":"10.1016/j.jor.2025.12.018","url":null,"abstract":"<div><h3>Background</h3><div>Orthopaedic surgery is among the most resource-intensive areas of healthcare, generating substantial waste, energy consumption, and carbon emissions. Operating rooms contribute disproportionately to a hospital's environmental footprint due to their high energy loads, extensive use of consumables, and complex supply chains. Despite rising global attention to sustainable healthcare, evidence specific to orthopaedic practice remains fragmented.</div></div><div><h3>Objectives</h3><div>This narrative review synthesises current evidence on the environmental impact of orthopaedic surgery, identifies major contributors to waste and carbon footprint, and outlines effective mitigation strategies applicable at institutional, clinical, and policy levels.</div></div><div><h3>Methods</h3><div>A structured search was conducted using MeSH and keyword combinations related to carbon footprint, sustainability, and orthopaedic surgery. Eligible studies included original research, reviews, and institutional reports assessing waste generation, CO<sub>2</sub>e emissions, energy use, or sustainability interventions. Two reviewers independently screened studies and performed thematic synthesis.</div></div><div><h3>Results</h3><div>Orthopaedic procedures generate 4–10 kg of waste per case, with plastics comprising nearly half. Life-cycle assessments report procedure-level emissions ranging from 28 to &gt;150 kg CO<sub>2</sub>e, highest in arthroplasty and spine surgery. Major footprint contributors include OR energy use, single-use consumables, implant manufacturing, sterilisation, and anaesthetic gases. Evidence demonstrates that tray optimisation, reusable systems, improved waste segregation, low-flow anaesthesia, and environmentally preferable procurement can reduce environmental impact by 20–70 %. However, methodological heterogeneity and limited data from low-income settings hinder the benchmarking process.</div></div><div><h3>Conclusion</h3><div>Orthopaedic surgery carries a significant environmental burden; however, multiple evidence-based strategies can substantially reduce its environmental footprint. Standardised assessment methods and broader global data are essential to guide sustainable surgical practice.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"73 ","pages":"Pages 86-94"},"PeriodicalIF":1.5,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet rich plasma augmentation for meniscus repair reduces failure but not complication rates or outcomes: A systematic review and meta-analysis 富血小板血浆增强半月板修复减少失败,但没有并发症发生率或结果:系统回顾和荟萃分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-09 DOI: 10.1016/j.jor.2025.12.015
Udit Dave , Jared Rubin , Nicole Chang , Nurudeen Alli , Myles Atkins , Thomas E. Moran , Andrew S. Bi , Monique Haynes , Nikhil N. Verma , Jorge Chahla

Introduction

Platelet rich plasma (PRP) has been shown to promote healing, especially in areas with poor vascularity, such as the inner third of the meniscus. The purpose of this systematic review and meta-analysis was to compare post-operative outcomes and complications among patients who have undergone meniscus repair with and without PRP augmentation.

Methods

In accordance with PRISMA guidelines, PubMed, Embase, and Cochrane Library databases were searched in December 2024 for studies published after 2004. Studies met inclusion criteria if they included patients who underwent meniscal repair without concomitant procedures and were comparative studies evaluating outcomes in patients who underwent meniscal repair with and without PRP treatment. Studies not written in English or not directly comparing patients undergoing meniscus repair with and without PRP were excluded. Two-proportion z-tests were performed to assess for a statistically significant difference in the proportion of each complication within the PRP cohort versus the control cohort. Risk of bias was assessed with the Cochrane Risk of Bias 2 tool for RCTs and MINORS criteria for non-RCTs.

Results

The initial search identified 862 studies, of which 8 were included, each with sufficiently low risk of bias. A total of 354 patients were included with 180 patients in the PRP cohort and 174 patients in the control cohort. Mean age across cohorts ranged from 26.0 to 70.0 years. Mean follow-up times ranged from 3.0 to 48.0 months. Similar mean values were reported in patient-reported outcomes including Lysholm, VAS, IKDC, and WOMAC scores across both cohorts. Patients undergoing meniscus repair with PRP augmentation had significantly fewer re-tears/failures (18.2 %) than patients undergoing repair without PRP augmentation (30.5 %), (p = 0.0188); however, there was no significant difference in rate of re-operations, wound complications, or infection between the two cohorts.

Conclusions

While significant heterogeneity in study methodology exists within the comparative literature, limited evidence exists suggesting a significantly decreased rate of re-tear or failure in patients undergoing meniscus repair with PRP augmentation versus without PRP augmentation.

Level of evidence

Level III, Systematic Review and Meta-Analysis of Level I-III studies.
富血小板血浆(PRP)已被证明可以促进愈合,特别是在血管不足的区域,如半月板的内三分之一。本系统综述和荟萃分析的目的是比较接受半月板修复术和不接受PRP增强术的患者的术后结果和并发症。方法根据PRISMA指南,检索PubMed、Embase和Cochrane图书馆数据库,于2024年12月检索2004年以后发表的研究。如果研究纳入的患者接受了半月板修复术,但未同时进行手术,并且是比较研究,评估半月板修复术患者接受和不接受PRP治疗的结果,则符合纳入标准。未以英文撰写或未直接比较接受半月板修复的患者是否接受PRP的研究被排除在外。采用双比例z检验来评估PRP队列与对照队列中每种并发症的比例是否存在统计学上的显著差异。偏倚风险评估采用Cochrane rct偏倚风险2工具,非rct采用未成年人标准。最初的检索确定了862项研究,其中8项被纳入,每项研究的偏倚风险都足够低。共纳入354例患者,其中180例为PRP组,174例为对照组。队列的平均年龄为26.0至70.0岁。平均随访时间3.0 ~ 48.0个月。在两个队列中,患者报告的结果(包括Lysholm、VAS、IKDC和WOMAC评分)的平均值相似。接受PRP增强半月板修复的患者再撕裂/失败(18.2%)明显少于未接受PRP增强修复的患者(30.5%),(p = 0.0188);然而,两组患者在再手术率、伤口并发症或感染方面没有显著差异。结论:虽然比较文献中研究方法存在显著的异质性,但有限的证据表明,接受PRP增强半月板修复的患者与未接受PRP增强的患者相比,再撕裂或失败率显著降低。证据水平:III级,I-III级研究的系统评价和荟萃分析。
{"title":"Platelet rich plasma augmentation for meniscus repair reduces failure but not complication rates or outcomes: A systematic review and meta-analysis","authors":"Udit Dave ,&nbsp;Jared Rubin ,&nbsp;Nicole Chang ,&nbsp;Nurudeen Alli ,&nbsp;Myles Atkins ,&nbsp;Thomas E. Moran ,&nbsp;Andrew S. Bi ,&nbsp;Monique Haynes ,&nbsp;Nikhil N. Verma ,&nbsp;Jorge Chahla","doi":"10.1016/j.jor.2025.12.015","DOIUrl":"10.1016/j.jor.2025.12.015","url":null,"abstract":"<div><h3>Introduction</h3><div>Platelet rich plasma (PRP) has been shown to promote healing, especially in areas with poor vascularity, such as the inner third of the meniscus. The purpose of this systematic review and meta-analysis was to compare post-operative outcomes and complications among patients who have undergone meniscus repair with and without PRP augmentation.</div></div><div><h3>Methods</h3><div>In accordance with PRISMA guidelines, PubMed, Embase, and Cochrane Library databases were searched in December 2024 for studies published after 2004. Studies met inclusion criteria if they included patients who underwent meniscal repair without concomitant procedures and were comparative studies evaluating outcomes in patients who underwent meniscal repair with and without PRP treatment. Studies not written in English or not directly comparing patients undergoing meniscus repair with and without PRP were excluded. Two-proportion z-tests were performed to assess for a statistically significant difference in the proportion of each complication within the PRP cohort versus the control cohort. Risk of bias was assessed with the Cochrane Risk of Bias 2 tool for RCTs and MINORS criteria for non-RCTs.</div></div><div><h3>Results</h3><div>The initial search identified 862 studies, of which 8 were included, each with sufficiently low risk of bias. A total of 354 patients were included with 180 patients in the PRP cohort and 174 patients in the control cohort. Mean age across cohorts ranged from 26.0 to 70.0 years. Mean follow-up times ranged from 3.0 to 48.0 months. Similar mean values were reported in patient-reported outcomes including Lysholm, VAS, IKDC, and WOMAC scores across both cohorts. Patients undergoing meniscus repair with PRP augmentation had significantly fewer re-tears/failures (18.2 %) than patients undergoing repair without PRP augmentation (30.5 %), (p = 0.0188); however, there was no significant difference in rate of re-operations, wound complications, or infection between the two cohorts.</div></div><div><h3>Conclusions</h3><div>While significant heterogeneity in study methodology exists within the comparative literature, limited evidence exists suggesting a significantly decreased rate of re-tear or failure in patients undergoing meniscus repair with PRP augmentation versus without PRP augmentation.</div></div><div><h3>Level of evidence</h3><div>Level III, Systematic Review and Meta-Analysis of Level I-III studies.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"73 ","pages":"Pages 62-71"},"PeriodicalIF":1.5,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classical non-traumatic osteonecrosis versus osteonecrosis of the jaw: Distinct manifestations of a shared pathophysiological spectrum 经典的非创伤性骨坏死与颌骨骨坏死:共同病理生理谱的不同表现
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-09 DOI: 10.1016/j.jor.2025.12.017
Edward Y. Cheng, Alireza Mirzaei

Introduction

Classical non-traumatic osteonecrosis (NTON)—most commonly affecting the femoral head—and osteonecrosis of the jaw (ONJ) represent two major forms of osteonecrosis. Ongoing debate persists regarding whether these conditions reflect manifestations of a shared underlying pathology or represent distinct clinical entities.

Hypothesis

We hypothesize that although NTON and ONJ share core mechanisms, their initiating events, osteoclastic responses, and reactions to anti-resorptive therapy differ sufficiently.

Methods

A comprehensive literature review was conducted using PubMed, Scopus, Web of Science, and the Cochrane Library. Evidence was synthesized regarding anatomical and mechanical differences, etiologic factors, pathogenic mechanisms, and therapeutic responses in NTON and ONJ.

Results

In NTON, compromised vascular supply is widely recognized as the primary initiating event, leading to hypoxia, increased osteoclastogenesis, and excessive bone resorption. In ONJ, impaired blood flow occurs secondarily, typically following dental trauma, infection, or anti-resorptive therapy. While both conditions involve disturbed bone homeostasis, NTON is characterized by heightened osteoclast activity, whereas ONJ features suppressed osteoclast function. This contrast results in divergent pharmacologic behavior: bisphosphonates and denosumab may be protective during the resorptive stage of NTON but significantly increase the risk of ONJ.

Conclusion

Although NTON and ONJ share fundamental disruptions in bone homeostasis and vascular regulation, their distinct initiating events, osteoclastic dynamics, and responses to anti-resorptive therapy suggest they are best viewed as separate clinical entities rather than variations of a single disease.
经典的非创伤性骨坏死(NTON)——最常影响股骨头——和颌骨骨坏死(ONJ)是骨坏死的两种主要形式。关于这些疾病是否反映了共同的基础病理表现,还是代表了不同的临床实体,目前的争论仍在继续。假设我们假设,尽管NTON和ONJ有共同的核心机制,但它们的起始事件、破骨细胞反应和对抗再吸收治疗的反应有很大的不同。方法采用PubMed、Scopus、Web of Science、Cochrane Library进行文献综述。综合了NTON和ONJ的解剖学和力学差异、病因、致病机制和治疗反应的证据。结果在NTON中,血管供应受损被广泛认为是主要的起始事件,导致缺氧、破骨细胞生成增加和骨吸收过度。在ONJ中,血流受损继发发生,通常发生在牙齿创伤、感染或抗吸收治疗之后。虽然这两种情况都涉及骨稳态紊乱,但NTON的特征是破骨细胞活性升高,而ONJ的特征是破骨细胞功能受到抑制。这种对比导致不同的药理学行为:双膦酸盐和地诺单抗在NTON的吸收阶段可能具有保护作用,但显著增加ONJ的风险。结论:尽管NTON和ONJ在骨稳态和血管调节方面有共同的基本破坏,但它们不同的起始事件、破骨细胞动力学和对抗吸收治疗的反应表明,它们最好被视为独立的临床实体,而不是单一疾病的变异。
{"title":"Classical non-traumatic osteonecrosis versus osteonecrosis of the jaw: Distinct manifestations of a shared pathophysiological spectrum","authors":"Edward Y. Cheng,&nbsp;Alireza Mirzaei","doi":"10.1016/j.jor.2025.12.017","DOIUrl":"10.1016/j.jor.2025.12.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Classical non-traumatic osteonecrosis (NTON)—most commonly affecting the femoral head—and osteonecrosis of the jaw (ONJ) represent two major forms of osteonecrosis. Ongoing debate persists regarding whether these conditions reflect manifestations of a shared underlying pathology or represent distinct clinical entities.</div></div><div><h3>Hypothesis</h3><div>We hypothesize that although NTON and ONJ share core mechanisms, their initiating events, osteoclastic responses, and reactions to anti-resorptive therapy differ sufficiently.</div></div><div><h3>Methods</h3><div>A comprehensive literature review was conducted using PubMed, Scopus, Web of Science, and the Cochrane Library. Evidence was synthesized regarding anatomical and mechanical differences, etiologic factors, pathogenic mechanisms, and therapeutic responses in NTON and ONJ.</div></div><div><h3>Results</h3><div>In NTON, compromised vascular supply is widely recognized as the primary initiating event, leading to hypoxia, increased osteoclastogenesis, and excessive bone resorption. In ONJ, impaired blood flow occurs secondarily, typically following dental trauma, infection, or anti-resorptive therapy. While both conditions involve disturbed bone homeostasis, NTON is characterized by heightened osteoclast activity, whereas ONJ features suppressed osteoclast function. This contrast results in divergent pharmacologic behavior: bisphosphonates and denosumab may be protective during the resorptive stage of NTON but significantly increase the risk of ONJ.</div></div><div><h3>Conclusion</h3><div>Although NTON and ONJ share fundamental disruptions in bone homeostasis and vascular regulation, their distinct initiating events, osteoclastic dynamics, and responses to anti-resorptive therapy suggest they are best viewed as separate clinical entities rather than variations of a single disease.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"73 ","pages":"Pages 55-61"},"PeriodicalIF":1.5,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridge Enhanced ACL Repair (BEAR) versus Bone Patella Tendon Bone (BPTB) ACL reconstruction among young athletes: A systematic review and meta-analysis 在年轻运动员中,桥增强ACL修复(BEAR)与骨髌骨肌腱骨(BPTB) ACL重建:系统回顾和荟萃分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-08 DOI: 10.1016/j.jor.2025.12.008
Kunal P. Shah , Timothy Gelatt , Kunal Damaraju , Jonathan Elias , Sameer Shah , Elizabeth Ford , Sean McMillan

Introduction

Anterior cruciate ligament (ACL) tears are among the leading causes of injuries among young athletes and are traditionally treated with surgical intervention. Recently, the Bridge Enhanced ACL Restoration (BEAR) procedure has gained popularity among surgeons as an alternative to ACL reconstruction (ACLR). Previously, BEAR has been compared to hamstring ACLR; however, little has been reported in comparison to bone-patella-tendon-bone (BPTB) ACLR, auto-, and allograft.

Purpose

To examine differences in the International Knee Documentation Committee (IKDC) scores of patients undergoing the BEAR procedure compared to BPTB for ACL tears.

Methods

A comprehensive search was conducted utilizing PRISMA 2020 guidelines. The search yielded 261 studies. Using Rayyan.ai, after the initial inclusion and exclusion, 14 studies underwent a full-text review. Inclusion criteria were randomized clinical trials for patients receiving either BEAR or BPTB with IKDC scores at 12- and 24-months. Statistical analysis was performed for random-effects meta-analysis using SPSS for the extracted IKDC scores.

Results

5 studies were included in the meta-analysis. At 12 months, comparison of BEAR (Cohen's d = 3.14) and BPTB (Cohen's d = 2.68) demonstrated no statistical difference. BEAR was found to have a higher clinical significance with an effect size difference of 0.48. A 24-month analysis yielded no clinical or statistical significance for BEAR (Cohen's d = 3.56) compared to BPTB (Cohen's d = 3.39).

Conclusion

Both BEAR and BPTB ACLR seemed to obtain comparable IKDC scores for addressing ACL injuries at 12- and 24-months post-procedure.
前交叉韧带(ACL)撕裂是年轻运动员受伤的主要原因之一,传统上通过手术干预治疗。最近,桥式增强前交叉韧带修复术(BEAR)作为前交叉韧带重建术(ACLR)的替代方法在外科医生中越来越受欢迎。此前,BEAR被比作腿筋ACLR;然而,与骨-髌骨-肌腱-骨(BPTB) ACLR、自体和同种异体移植相比,很少有报道。目的研究国际膝关节文献委员会(IKDC)对前交叉韧带撕裂患者行BEAR手术与行BPTB手术的评分差异。方法采用PRISMA 2020指南进行综合检索。这项搜索共产生了261项研究。使用Rayyan。在最初的纳入和排除之后,14项研究进行了全文综述。纳入标准是接受BEAR或BPTB的患者在12个月和24个月的IKDC评分的随机临床试验。采用SPSS对提取的IKDC评分进行随机效应荟萃分析。结果meta分析共纳入5项研究。12个月时,BEAR (Cohen’s d = 3.14)与BPTB (Cohen’s d = 2.68)比较无统计学差异。BEAR具有较高的临床意义,效应量差异为0.48。24个月的分析显示,与BPTB (Cohen’s d = 3.39)相比,BEAR (Cohen’s d = 3.56)没有临床或统计学意义。结论BEAR和BPTB ACLR在术后12个月和24个月处理ACL损伤时似乎获得了相当的IKDC评分。
{"title":"Bridge Enhanced ACL Repair (BEAR) versus Bone Patella Tendon Bone (BPTB) ACL reconstruction among young athletes: A systematic review and meta-analysis","authors":"Kunal P. Shah ,&nbsp;Timothy Gelatt ,&nbsp;Kunal Damaraju ,&nbsp;Jonathan Elias ,&nbsp;Sameer Shah ,&nbsp;Elizabeth Ford ,&nbsp;Sean McMillan","doi":"10.1016/j.jor.2025.12.008","DOIUrl":"10.1016/j.jor.2025.12.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Anterior cruciate ligament (ACL) tears are among the leading causes of injuries among young athletes and are traditionally treated with surgical intervention. Recently, the Bridge Enhanced ACL Restoration (BEAR) procedure has gained popularity among surgeons as an alternative to ACL reconstruction (ACLR). Previously, BEAR has been compared to hamstring ACLR; however, little has been reported in comparison to bone-patella-tendon-bone (BPTB) ACLR, auto-, and allograft.</div></div><div><h3>Purpose</h3><div>To examine differences in the International Knee Documentation Committee (IKDC) scores of patients undergoing the BEAR procedure compared to BPTB for ACL tears.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted utilizing PRISMA 2020 guidelines. The search yielded 261 studies. Using Rayyan.ai, after the initial inclusion and exclusion, 14 studies underwent a full-text review. Inclusion criteria were randomized clinical trials for patients receiving either BEAR or BPTB with IKDC scores at 12- and 24-months. Statistical analysis was performed for random-effects meta-analysis using SPSS for the extracted IKDC scores.</div></div><div><h3>Results</h3><div>5 studies were included in the meta-analysis. At 12 months, comparison of BEAR (Cohen's d = 3.14) and BPTB (Cohen's d = 2.68) demonstrated no statistical difference. BEAR was found to have a higher clinical significance with an effect size difference of 0.48. A 24-month analysis yielded no clinical or statistical significance for BEAR (Cohen's d = 3.56) compared to BPTB (Cohen's d = 3.39).</div></div><div><h3>Conclusion</h3><div>Both BEAR and BPTB ACLR seemed to obtain comparable IKDC scores for addressing ACL injuries at 12- and 24-months post-procedure.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"73 ","pages":"Pages 30-41"},"PeriodicalIF":1.5,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of implant generation on the outcomes in medial pivot total knee arthroplasty: a systematic review 植入物生成对内侧枢轴全膝关节置换术疗效的影响:一项系统综述
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-08 DOI: 10.1016/j.jor.2025.12.007
Filippo Migliorini , Marco Pilone , Luise Schäfer , Raju Vaishya , Michael Memminger , Nicola Maffulli

Introduction

Medial pivot total knee arthroplasty (TKA) was developed to reproduce native knee kinematics and improve function. Second-generation designs introduced refinements to enhance medial conformity and lateral rollback, but their clinical benefit remains uncertain. This systematic review compared outcomes of first- and second-generation medial pivot implants.

Methods

A comprehensive search of PubMed, Web of Science, Embase, and Google Scholar was performed in August 2025 following PRISMA guidelines. Comparative and non-comparative studies reporting outcomes after first- or second-generation medial pivot TKA were included. Primary endpoints were Knee Society Score (KSS), functional subscale (KSS-F), Oxford Knee Score (OKS), WOMAC, Forgotten Joint Score (FJS), range of motion (ROM), and revision rates.

Results

Twenty-four studies including 4686 patients (3541 first-generation; 1145 s-generation) were analysed. Most baseline variables were comparable, though BMI, follow-up duration, and baseline WOMAC and ROM showed minor differences. At the latest follow-up, KSS, KSS-F, WOMAC, and FJS showed no significant differences. Revision rates were similar. OKS was slightly lower in the second-generation cohort (MD −2.5, p = 0.04), and ROM was greater (MD 4.6°, p = 0.01), but both fell below minimal clinically important difference thresholds.

Conclusion

First- and second-generation medial pivot TKAs achieved comparable outcomes and survivorship. Although second-generation designs showed statistical improvements in ROM and OKS, these were not clinically relevant. These findings suggest that while design refinements of second-generation implants may offer minor biomechanical advantages, they do not translate into significant improvements in patient-reported outcomes. Surgical decision-making should be based on the surgeon's experience, implant availability, and patient-specific factors rather than expectations of superior performance from newer designs.

Level of evidence

Level III.
内侧枢轴全膝关节置换术(TKA)的发展是为了恢复膝关节的运动学和改善功能。第二代设计引入了改进,以增强内侧整合和侧退,但其临床效益仍不确定。本系统综述比较了第一代和第二代内侧枢轴植入物的疗效。方法于2025年8月按照PRISMA指南对PubMed、Web of Science、Embase和谷歌Scholar进行综合检索。比较和非比较研究报告了第一代或第二代内侧支点TKA后的结果。主要终点是膝关节社会评分(KSS)、功能量表(KSS- f)、牛津膝关节评分(OKS)、WOMAC、遗忘关节评分(FJS)、活动范围(ROM)和翻修率。结果共纳入24项研究,共4686例患者(第一代3541例,第一代1145例)。大多数基线变量具有可比性,尽管BMI、随访时间、基线WOMAC和ROM显示出微小差异。最新随访时,KSS、KSS- f、WOMAC、FJS无显著差异。复习率相似。第二代队列的OKS略低(MD - 2.5, p = 0.04), ROM更高(MD 4.6°,p = 0.01),但均低于最小临床重要差异阈值。结论:第一代和第二代中间支点tka的预后和生存期相当。虽然第二代设计显示ROM和OKS有统计学上的改善,但这些与临床无关。这些发现表明,虽然第二代植入物的设计改进可能提供较小的生物力学优势,但它们并没有转化为患者报告结果的显着改善。手术决策应基于外科医生的经验、植入物的可用性和患者的具体因素,而不是期望新设计的优越性能。证据等级:III级。
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引用次数: 0
Ethnic and sex-specific differences in proximal femoral geometry and its implications for prosthetic design in total hip arthroplasty - A systematic analysis 全髋关节置换术中股骨近端几何形状的种族和性别差异及其对假体设计的影响-系统分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2025-12-08 DOI: 10.1016/j.jor.2025.12.005
Ram Sudhan S , Yashwanth Krishna , Vinayak Prabhu , Nahas R , Mohamed Azhaarudeen A , Naveen P. Gopinath , Daku Jadav , Hishanil Rasheed N.K , Avinash TP , Sharat Balemane
Restoration of proximal femoral geometry is critical for total hip arthroplasty (THA) success, yet ethnic and sex-based morphological variations remain inadequately characterised. This systematic review synthesises morphometric evidence across multiple ethnic cohorts to inform implant design and surgical planning. A 3-year systematic review was conducted at Yenepoya Medical College (June 2022–present), searching multiple databases for studies reporting proximal femoral parameters in Chinese, Korean, Japanese, European, and Brazilian populations using radiography and 3D-CT imaging. An in-vivo Indian cohort of 96 hips was included for clinical correlation. Studies lacking ethnic/sex stratification, involving pediatric populations, or with inadequate methodology were excluded. Quality assessment used the Newcastle–Ottawa Scale (≥6 points retained). Sex-stratified data extraction was performed using fixed/random-effects meta-analyses, with meta-regression evaluating ethnicity and sex as predictors of geometric parameters (α = 0.05). Six studies were analyzed, representing six ethnic populations plus one in-vivo cohort (n = 727 femurs). Korean males showed the largest femoral head diameter (48.50 ± 2.23 mm) compared to Brazilian males (31.1 ± 2.7 mm), a 17.4 mm disparity. Neck-shaft angles varied between 126.35° and 132.1° across populations. Chinese females exhibited the highest anteversion (29.03 ± 2.73°) versus males (11.66 ± 1.55°), representing a 149 % difference. Brazilian populations displayed minimal sexual dimorphism (<2 %). Indian CT measurements revealed systematically lower head diameter values compared to radiography (43.0 ± 2.6 vs 48.4 ± 2.6 mm in males). Substantial ethnic and sex-specific differences in proximal femoral geometry necessitate ethnicity-conscious and sex-specific implant modularity or customization to prevent offset under-restoration, impingement, and accelerated bone resorption, rather than relying on universal implant designs.
股骨近端几何形状的恢复对于全髋关节置换术(THA)的成功至关重要,然而基于种族和性别的形态变化仍然没有充分的特征。本系统综述综合了多种族人群的形态计量学证据,为植入物设计和手术计划提供信息。叶纳波亚医学院(2022年6月-至今)进行了一项为期3年的系统评价,检索了多个数据库中使用x线摄影和3D-CT成像报道中国、韩国、日本、欧洲和巴西人群股骨近端参数的研究。一个96髋的印度体内队列被纳入临床相关性。排除了缺乏种族/性别分层、涉及儿科人群或方法学不充分的研究。质量评估采用纽卡斯尔-渥太华量表(保留≥6分)。采用固定/随机效应meta分析进行性别分层数据提取,meta回归评估种族和性别作为几何参数的预测因子(α = 0.05)。分析了6项研究,代表6个民族人群和1个体内队列(n = 727根股骨)。韩国男性的股骨头直径(48.50±2.23 mm)比巴西男性(31.1±2.7 mm)大17.4 mm。颈轴角在126.35°~ 132.1°之间变化。中国女性的前倾度最高(29.03±2.73°),男性为11.66±1.55°,差异达149%。巴西人群表现出最小的性别二态性(2%)。印度CT测量显示,与x线摄影相比,头部直径值系统性降低(男性为43.0±2.6 mm,男性为48.4±2.6 mm)。股骨近端几何形状存在明显的种族和性别差异,因此需要有种族意识和性别特异性的植入物模块或定制,以防止移位复位不足、撞击和加速骨吸收,而不是依赖于通用的植入物设计。
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引用次数: 0
期刊
Journal of orthopaedics
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