首页 > 最新文献

Journal of orthopaedics最新文献

英文 中文
Xylosyltransferase-I in knee arthrofibrosis: Mechanistic insights and translational implications 木糖基转移酶- 1在膝关节纤维化中的作用:机制见解和翻译意义
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jor.2026.02.031
Yong Huang , Chao Lou , Michael Jagodzinski

Background

Arthrofibrosis is a frequent complication after total knee arthroplasty (TKA) and remains difficult to diagnose early due to the lack of reliable biomarkers. Excessive extracellular matrix (ECM) remodeling is driven by core signaling cascades, notably the Transforming Growth Factor-beta 1 (TGF-ß1) and Wnt/ß-catenin pathways. Xylosyltransferase-I (XT-I), a key enzyme regulating proteoglycan biosynthesis, has emerged as a critical downstream effector and potential indicator of early fibrotic activity.

Methods

This narrative review summarizes clinical and experimental findings on XT-I in joint fibrosis, with emphasis on its role within the molecular network of key pro-fibrotic signaling and its diagnostic and translational potential in knee arthrofibrosis.

Results

XT-I is consistently upregulated in fibrotic synovial fibroblasts and synovial fluid of arthrofibrotic knees, correlating with ECM remodeling and myofibroblast activation induced by both TGF-ß1and Wnt/ß-catenin signaling. XT-I demonstrates local rather than systemic diagnostic value and may serve as an early fibrosis indicator.

Conclusion

XT-I holds promise as a synovial biomarker and potential therapeutic target in arthrofibrosis. Targeting XT-I, potentially in combination with core pathway inhibitors (e.g., Wnt/ß-catenin inhibitors), may offer a refined strategy for early diagnosis and postoperative management in TKA patients.
背景:膝关节纤维化是全膝关节置换术(TKA)后常见的并发症,由于缺乏可靠的生物标志物,仍然难以早期诊断。过度的细胞外基质(ECM)重塑是由核心信号级联驱动的,特别是转化生长因子- β 1 (TGF-ß1)和Wnt/ß-catenin途径。Xylosyltransferase-I (XT-I)是一种调节蛋白聚糖生物合成的关键酶,已成为关键的下游效应物和早期纤维化活性的潜在指标。方法本文综述了xt - 1在关节纤维化中的临床和实验发现,重点介绍了xt - 1在关键促纤维化信号分子网络中的作用及其在膝关节纤维化中的诊断和转化潜力。结果xt - i在关节纤维化膝滑膜成纤维细胞和滑膜液中持续上调,与TGF-ß1和Wnt/ß-catenin信号诱导的ECM重塑和肌成纤维细胞活化有关。x - 1表现出局部而非全身的诊断价值,可作为早期纤维化指标。结论xt - i作为滑膜生物标志物和潜在的关节纤维化治疗靶点具有广阔的应用前景。靶向XT-I,可能与核心途径抑制剂(如Wnt/ß-catenin抑制剂)联合使用,可能为TKA患者的早期诊断和术后管理提供一种完善的策略。
{"title":"Xylosyltransferase-I in knee arthrofibrosis: Mechanistic insights and translational implications","authors":"Yong Huang ,&nbsp;Chao Lou ,&nbsp;Michael Jagodzinski","doi":"10.1016/j.jor.2026.02.031","DOIUrl":"10.1016/j.jor.2026.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Arthrofibrosis is a frequent complication after total knee arthroplasty (TKA) and remains difficult to diagnose early due to the lack of reliable biomarkers. Excessive extracellular matrix (ECM) remodeling is driven by core signaling cascades, notably the Transforming Growth Factor-beta 1 (TGF-ß1) and Wnt/ß-catenin pathways. Xylosyltransferase-I (XT-I), a key enzyme regulating proteoglycan biosynthesis, has emerged as a critical downstream effector and potential indicator of early fibrotic activity.</div></div><div><h3>Methods</h3><div>This narrative review summarizes clinical and experimental findings on XT-I in joint fibrosis, with emphasis on its role within the molecular network of key pro-fibrotic signaling and its diagnostic and translational potential in knee arthrofibrosis.</div></div><div><h3>Results</h3><div>XT-I is consistently upregulated in fibrotic synovial fibroblasts and synovial fluid of arthrofibrotic knees, correlating with ECM remodeling and myofibroblast activation induced by both TGF-ß1and Wnt/ß-catenin signaling. XT-I demonstrates local rather than systemic diagnostic value and may serve as an early fibrosis indicator.</div></div><div><h3>Conclusion</h3><div>XT-I holds promise as a synovial biomarker and potential therapeutic target in arthrofibrosis. Targeting XT-I, potentially in combination with core pathway inhibitors (e.g., Wnt/ß-catenin inhibitors), may offer a refined strategy for early diagnosis and postoperative management in TKA patients.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 40-45"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calculating and comparing value in orthopaedic hip trauma: A systematic review 计算和比较骨科髋关节创伤的价值:一项系统综述
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jor.2026.02.043
Lindsay Maier , Zachary Chen , Mithil Gudi , Spencer Barlow , Trae Hill , Charles S. Day

Objectives

To evaluate the existing literature on value comparisons between treatment strategies in orthopaedic hip fracture care using real-world clinical data and standardized cost-effectiveness metrics.
Materials and Methods

Data sources

A comprehensive search of PubMed, Embase, and Web of Science was conducted for studies published between January 1, 2003, and May 30, 2024. Only English-language articles were included.

Study selection

Eligible studies directly compared two or more treatment strategies for hip fracture care and included a value-based economic evaluation using clinical (non-simulated) data. Exclusion criteria included simulation models, protocols, case reports, systematic reviews, and meta-analyses.

Data extraction

Two independent reviewers screened titles, abstracts, and full texts using PRISMA guidelines. Discrepancies were resolved by a third reviewer. Extracted variables included study design, intervention type, cost perspective, quality metric used, and economic evaluation method.

Data synthesis

Studies were analyzed descriptively. Outcome measures included cost-effectiveness ratios such as ICER, ICUR, and NMB. QALYs were used to enable cross-study comparisons.

Results

Sixteen of 935 screened full-text articles met inclusion criteria. Most studies evaluated surgical interventions. Cemented hemiarthroplasty showed a favorable NMB compared to uncemented implants. Liposomal bupivacaine and tranexamic acid were cost-effective due to lower operating costs and shorter hospital stays. Internal fixation was more cost-effective than hemiarthroplasty in some settings despite lower quality outcomes. Operative treatment in frail, institutionalized patients offered minimal QALY benefit at high cost. Home-based post-acute care and fracture liaison services improved value, while outreach rehab lacked long-term cost-effectiveness. Most studies used public payer perspectives and EQ-5D-derived QALYs.

Conclusion

There is significant variability in how value is calculated and reported in hip fracture care. Standardized value frameworks using a hospital/clinic perspective, patient-reported outcomes transformed into QALYs, and cost-utility ratios compared with the ICER equation should be utilized in future studies.

Level of evidence

Level III (Systematic Review of Comparative Studies)
目的利用真实世界的临床数据和标准化的成本-效果指标对骨科髋部骨折治疗策略的价值比较进行评估。资料与方法数据来源对2003年1月1日至2024年5月30日期间发表的研究进行了PubMed、Embase和Web of Science的综合检索。只包括英文文章。研究选择:符合条件的研究直接比较髋部骨折护理的两种或多种治疗策略,并使用临床(非模拟)数据进行基于价值的经济评估。排除标准包括模拟模型、方案、病例报告、系统评价和荟萃分析。数据提取:两名独立审稿人使用PRISMA指南筛选标题、摘要和全文。差异由第三位审稿人解决。提取的变量包括研究设计、干预类型、成本视角、使用的质量度量和经济评价方法。数据综合:对研究进行描述性分析。结果测量包括成本-效果比,如ICER、ICUR和NMB。使用质量分析来进行交叉研究比较。结果935篇筛选的全文文章中有16篇符合纳入标准。大多数研究评估手术干预。与非骨水泥植入物相比,骨水泥半关节置换术显示出良好的NMB。布比卡因和氨甲环酸脂质体由于较低的操作成本和较短的住院时间而具有成本效益。尽管结果质量较低,但在某些情况下,内固定比半关节置换术更具成本效益。对于体弱的住院患者,手术治疗在高成本下提供了最低的质量效益。以家庭为基础的急性后护理和骨折联络服务提高了价值,而外展康复缺乏长期的成本效益。大多数研究使用公共付款人的观点和eq - 5d衍生的质量分析。结论髋部骨折护理中价值的计算和报道存在显著差异。采用医院/诊所视角的标准化价值框架,将患者报告的结果转化为质量质量年,并将成本效用比与ICER方程进行比较,应在未来的研究中加以利用。证据水平III级(比较研究系统综述)
{"title":"Calculating and comparing value in orthopaedic hip trauma: A systematic review","authors":"Lindsay Maier ,&nbsp;Zachary Chen ,&nbsp;Mithil Gudi ,&nbsp;Spencer Barlow ,&nbsp;Trae Hill ,&nbsp;Charles S. Day","doi":"10.1016/j.jor.2026.02.043","DOIUrl":"10.1016/j.jor.2026.02.043","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the existing literature on value comparisons between treatment strategies in orthopaedic hip fracture care using real-world clinical data and standardized cost-effectiveness metrics.</div><div>Materials and Methods</div></div><div><h3>Data sources</h3><div>A comprehensive search of PubMed, Embase, and Web of Science was conducted for studies published between January 1, 2003, and May 30, 2024. Only English-language articles were included.</div></div><div><h3>Study selection</h3><div>Eligible studies directly compared two or more treatment strategies for hip fracture care and included a value-based economic evaluation using clinical (non-simulated) data. Exclusion criteria included simulation models, protocols, case reports, systematic reviews, and meta-analyses.</div></div><div><h3>Data extraction</h3><div>Two independent reviewers screened titles, abstracts, and full texts using PRISMA guidelines. Discrepancies were resolved by a third reviewer. Extracted variables included study design, intervention type, cost perspective, quality metric used, and economic evaluation method.</div></div><div><h3>Data synthesis</h3><div>Studies were analyzed descriptively. Outcome measures included cost-effectiveness ratios such as ICER, ICUR, and NMB. QALYs were used to enable cross-study comparisons.</div></div><div><h3>Results</h3><div>Sixteen of 935 screened full-text articles met inclusion criteria. Most studies evaluated surgical interventions. Cemented hemiarthroplasty showed a favorable NMB compared to uncemented implants. Liposomal bupivacaine and tranexamic acid were cost-effective due to lower operating costs and shorter hospital stays. Internal fixation was more cost-effective than hemiarthroplasty in some settings despite lower quality outcomes. Operative treatment in frail, institutionalized patients offered minimal QALY benefit at high cost. Home-based post-acute care and fracture liaison services improved value, while outreach rehab lacked long-term cost-effectiveness. Most studies used public payer perspectives and EQ-5D-derived QALYs.</div></div><div><h3>Conclusion</h3><div>There is significant variability in how value is calculated and reported in hip fracture care. Standardized value frameworks using a hospital/clinic perspective, patient-reported outcomes transformed into QALYs, and cost-utility ratios compared with the ICER equation should be utilized in future studies.</div></div><div><h3>Level of evidence</h3><div>Level III (Systematic Review of Comparative Studies)</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 168-176"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes following single-level lumbar fusion in patients with myasthenia gravis 重症肌无力患者单节段腰椎融合术的疗效
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jor.2026.02.027
Danielle B. Heckert , Julia Jezykowski , Clare K. Green , Joyce En-Hua Wang , Ved A. Vengsarkar , Wendy Novicoff , Xudong Li , Stephen Lockey

Introduction

Patients with myasthenia gravis (MG) are at higher risk for postoperative complications after surgery. Knowledge concerning the impact of the condition on outcomes and complications after spine surgery is currently limited. Using a large-scale, national database, the purpose of this investigation was to compare the rate of medical and surgical complications, healthcare utilization, and need for revision surgery following single-level lumbar fusion between patients with and without MG.

Methods

Data was collected using the PearlDiver database and adult patients with and without MG who underwent single-level lumbar spine fusion from 2010 to 2022 were matched 1:4 on age, sex, and baselin comorbidities. Pearson's Chi-squared test and Welch's t-test were used to evaluate differences in demographic and clinical outcomes. Univariate analysis and multivariate logistic regression were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) after controlling for potential confounders.

Results

A total of 537 (20.0%) patients with MG were matched with 2140 (80.0%) patients controls. At 90 days postoperatively, patients with MG experienced significantly higher rates of postoperative arrhythmia, cerebrovascular accident, atelectasis, respiratory failure, pleural effusion, pulmonary embolism, urinary retention, urinary tract infection, and renal failure. At two-year follow up, 27 (5.0%) patients with MG developed pseudoarthrosis compared to 48 (2.2%) controls (OR 2.32; 95% CI: 1.41-3.74; p < 0.001), and 38 (7.1%) MG patients had undergone revision lumbar spine surgery compared to 61 (2.9%) controls (OR: 2.61; 95% CI: 1.70-3.95; p < 0.001). Regarding healthcare utilization, patients with MG were more likely to present to the emergency department and require readmission at both 30 and 90 days postoperatively.

Conclusion

Patients with MG experienced more postoperative complications and higher healthcare utilization after single-level lumbar fusion. These findings highlight the importance of individualized perioperative planning to mitigate risks and inform surgeon counseling of patients and their families.
重症肌无力(MG)患者术后并发症发生率较高。目前关于脊柱手术后病情对预后和并发症的影响的知识有限。使用一个大规模的国家数据库,本研究的目的是比较有MG和无MG患者单节段腰椎融合术后的内科和外科并发症的发生率、医疗保健的利用以及翻修手术的需要。方法使用PearlDiver数据库收集数据,2010年至2022年接受单节段腰椎融合术的成年MG和非MG患者在年龄、性别和基线合并症方面按1:4匹配。使用Pearson卡方检验和Welch t检验来评估人口学和临床结果的差异。在控制潜在混杂因素后,进行单因素分析和多因素logistic回归计算优势比(ORs)和95%置信区间(CIs)。结果537例MG患者(20.0%)与对照组2140例(80.0%)匹配。在术后90天,MG患者出现术后心律失常、脑血管意外、肺不张、呼吸衰竭、胸腔积液、肺栓塞、尿潴留、尿路感染和肾功能衰竭的发生率明显较高。在两年的随访中,27例(5.0%)MG患者发生假关节,而对照组为48例(2.2%)(OR 2.32; 95% CI: 1.41-3.74; p < 0.001), 38例(7.1%)MG患者接受了腰椎翻修手术,而对照组为61例(2.9%)(OR: 2.61; 95% CI: 1.70-3.95; p < 0.001)。在医疗保健利用方面,MG患者更有可能出现在急诊科,并在术后30天和90天再次入院。结论单节段腰椎融合术后MG患者并发症较多,医疗保健利用率较高。这些发现强调了个体化围手术期计划的重要性,以减轻风险,并告知外科医生对患者及其家属的咨询。
{"title":"Outcomes following single-level lumbar fusion in patients with myasthenia gravis","authors":"Danielle B. Heckert ,&nbsp;Julia Jezykowski ,&nbsp;Clare K. Green ,&nbsp;Joyce En-Hua Wang ,&nbsp;Ved A. Vengsarkar ,&nbsp;Wendy Novicoff ,&nbsp;Xudong Li ,&nbsp;Stephen Lockey","doi":"10.1016/j.jor.2026.02.027","DOIUrl":"10.1016/j.jor.2026.02.027","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with myasthenia gravis (MG) are at higher risk for postoperative complications after surgery. Knowledge concerning the impact of the condition on outcomes and complications after spine surgery is currently limited. Using a large-scale, national database, the purpose of this investigation was to compare the rate of medical and surgical complications, healthcare utilization, and need for revision surgery following single-level lumbar fusion between patients with and without MG.</div></div><div><h3>Methods</h3><div>Data was collected using the PearlDiver database and adult patients with and without MG who underwent single-level lumbar spine fusion from 2010 to 2022 were matched 1:4 on age, sex, and baselin comorbidities. Pearson's Chi-squared test and Welch's <em>t</em>-test were used to evaluate differences in demographic and clinical outcomes. Univariate analysis and multivariate logistic regression were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) after controlling for potential confounders.</div></div><div><h3>Results</h3><div>A total of 537 (20.0%) patients with MG were matched with 2140 (80.0%) patients controls. At 90 days postoperatively, patients with MG experienced significantly higher rates of postoperative arrhythmia, cerebrovascular accident, atelectasis, respiratory failure, pleural effusion, pulmonary embolism, urinary retention, urinary tract infection, and renal failure. At two-year follow up, 27 (5.0%) patients with MG developed pseudoarthrosis compared to 48 (2.2%) controls (OR 2.32; 95% CI: 1.41-3.74; p &lt; 0.001), and 38 (7.1%) MG patients had undergone revision lumbar spine surgery compared to 61 (2.9%) controls (OR: 2.61; 95% CI: 1.70-3.95; p &lt; 0.001). Regarding healthcare utilization, patients with MG were more likely to present to the emergency department and require readmission at both 30 and 90 days postoperatively.</div></div><div><h3>Conclusion</h3><div>Patients with MG experienced more postoperative complications and higher healthcare utilization after single-level lumbar fusion. These findings highlight the importance of individualized perioperative planning to mitigate risks and inform surgeon counseling of patients and their families.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 57-61"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of early pelvic Fracture risk after rotational acetabular osteotomy: Finite element analysis of pelvic stress distribution 髋臼旋转截骨术后早期骨盆骨折风险评估:骨盆应力分布的有限元分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.1016/j.jor.2026.02.022
Tsuguaki Hosoyama , Nobuhiro Kaku , Yutaro Shibuta , Kensei Tanaka

Background

This study evaluated stress distribution across the entire pelvis following rotational acetabular osteotomy (RAO) for osteoarthritis secondary to acetabular dysplasia using finite element analysis (FEA). Additionally, we aimed to elucidate the mechanisms underlying postoperative posterior column and inferior pubic ramus fractures, which are recognized complications of RAO.

Methods

FEA was conducted based on the computed tomography (CT) images of a 26-year-old female patient who developed a posterior column fracture following RAO. Three pelvic models were constructed: preoperative, immediately postoperative, and 1 year postoperatively, in which osseous union was achieved between the rotated fragment and the ilium; however, the osteotomy site at the superior pubic ramus resulted in nonunion. Additionally, a Union model, simulating the continuity of the superior pubic ramus in both postoperative stages, was created for comparison with the Nonunion model. A load of 500 N was applied in a sitting position, with the von Mises stress distribution and element failure patterns analyzed.

Results

In the Nonunion model, von Mises stress at the inferior pubic ramus was approximately 3.6 times higher immediately after surgery than preoperatively (43.0 MPa) and approximately 2.6 times higher than in the Union model. Similarly, the stress in the posterior column increased approximately 5.1-fold (53.9 MPa) immediately postoperatively in the Nonunion model, which was approximately 3.2 times higher (34.2 MPa) than in the Union model. Furthermore, element failure was observed in areas where stress exceeded 30 MPa, with a high incidence of failure in the immediate postoperative Nonunion model.

Conclusion

Early post-RAO fractures of the posterior column and inferior pubic ramus are significantly influenced by the continuity of the superior pubic ramus. Notably, even before weight-bearing begins, the presence of a gap at the pubic osteotomy site immediately after RAO may substantially elevate fracture risk.
本研究利用有限元分析(FEA)评估髋臼旋转截骨术(RAO)治疗髋臼发育不良继发骨关节炎后整个骨盆的应力分布。此外,我们的目的是阐明术后后柱和耻骨下支骨折的机制,这是公认的RAO并发症。方法对一位26岁女性患者的CT图像进行有限元分析,该患者在RAO术后发生后柱骨折。我们分别在术前、术后和术后1年建立了三种骨盆模型,其中旋转碎片与髂骨之间实现了骨愈合;然而,耻骨上支截骨导致骨不连。此外,创建了一个模拟上耻骨支在术后两个阶段连续性的骨连模型,与骨不连模型进行比较。在坐姿下施加500 N的载荷,分析了von Mises应力分布和元件破坏模式。结果骨不连模型下耻骨下支的von Mises应力即刻比术前(43.0 MPa)高约3.6倍,比骨不连模型高约2.6倍。同样,术后未愈合模型的后柱应力立即增加约5.1倍(53.9 MPa),比愈合模型高约3.2倍(34.2 MPa)。此外,在应力超过30 MPa的区域观察到元件失效,在术后立即骨不连模型中失效的发生率很高。结论耻骨上支的连续性对术后早期后柱及耻骨下支骨折有显著影响。值得注意的是,即使在负重开始之前,RAO术后耻骨截骨部位出现间隙可能会大大增加骨折风险。
{"title":"Evaluation of early pelvic Fracture risk after rotational acetabular osteotomy: Finite element analysis of pelvic stress distribution","authors":"Tsuguaki Hosoyama ,&nbsp;Nobuhiro Kaku ,&nbsp;Yutaro Shibuta ,&nbsp;Kensei Tanaka","doi":"10.1016/j.jor.2026.02.022","DOIUrl":"10.1016/j.jor.2026.02.022","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated stress distribution across the entire pelvis following rotational acetabular osteotomy (RAO) for osteoarthritis secondary to acetabular dysplasia using finite element analysis (FEA). Additionally, we aimed to elucidate the mechanisms underlying postoperative posterior column and inferior pubic ramus fractures, which are recognized complications of RAO.</div></div><div><h3>Methods</h3><div>FEA was conducted based on the computed tomography (CT) images of a 26-year-old female patient who developed a posterior column fracture following RAO. Three pelvic models were constructed: preoperative, immediately postoperative, and 1 year postoperatively, in which osseous union was achieved between the rotated fragment and the ilium; however, the osteotomy site at the superior pubic ramus resulted in nonunion. Additionally, a Union model, simulating the continuity of the superior pubic ramus in both postoperative stages, was created for comparison with the Nonunion model. A load of 500 N was applied in a sitting position, with the von Mises stress distribution and element failure patterns analyzed.</div></div><div><h3>Results</h3><div>In the Nonunion model, von Mises stress at the inferior pubic ramus was approximately 3.6 times higher immediately after surgery than preoperatively (43.0 MPa) and approximately 2.6 times higher than in the Union model. Similarly, the stress in the posterior column increased approximately 5.1-fold (53.9 MPa) immediately postoperatively in the Nonunion model, which was approximately 3.2 times higher (34.2 MPa) than in the Union model. Furthermore, element failure was observed in areas where stress exceeded 30 MPa, with a high incidence of failure in the immediate postoperative Nonunion model.</div></div><div><h3>Conclusion</h3><div>Early post-RAO fractures of the posterior column and inferior pubic ramus are significantly influenced by the continuity of the superior pubic ramus. Notably, even before weight-bearing begins, the presence of a gap at the pubic osteotomy site immediately after RAO may substantially elevate fracture risk.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 120-125"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reassuring early serum metal ion levels with a specific modular dual mobility system 通过特定的模块化双移动系统,确保早期血清金属离子水平
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jor.2026.02.012
Michael J. Archibeck, Brenna E. Blackburn, Claire R. Kapron, Lucas A. Anderson, Jeremy M. Gililland, Christopher L. Peters, Christopher E. Pelt

Introduction

The popularity of modular dual mobility (MDM) acetabular components has increased. Concerns have been raised about the potential for corrosion related complications in these modular implants. The purpose of this study was to prospectively monitor serum ion levels in a series of patients with a modular dual mobility system.

Methods

Twenty-six patients with the Zimmer Biomet G7 DM construct were enrolled and followed for a minimum of one year. Serum cobalt, chromium, and titanium levels were obtained prior to six-weeks postoperatively and at one and two-years postoperatively. Five-year labs were obtained if previous labs were elevated.

Results

At 0-6 weeks postoperatively, 4/26 patients had mildly elevated cobalt levels (1-2.8 μg/L) and 2/26 had mildly elevated chromium levels (1.6, 2.0 μg/L). None of the 19 patients showed elevated cobalt levels at one or two years, while 4/19 reported mildly elevated chromium levels (1.1-1.3 μg/L) at one-year with a slight decrease (1-1.4 μg/L) at two-years. No patients at any time point had metal ion levels exceeding the initial early threshold of 5 μg/L. No patient was symptomatic and no MRIs were indicated or obtained.

Discussion

In this series of a specific modular DM system, the early mildly elevated cobalt levels in four patients all subsequently normalized. Chromium was mildly elevated in four patients through year two. While these findings are reassuring in the short term as mildly elevated chromium (<2 μg/L) has not been associated with clinical toxicity, additional follow-up is needed to establish the long-term safety and efficacy of this specific modular DM implant.
模块化双活动(MDM)髋臼假体越来越受欢迎。人们对这些模块化植入物中潜在的与腐蚀相关的并发症表示担忧。本研究的目的是前瞻性监测一系列采用模块化双活动系统的患者的血清离子水平。方法纳入26例采用Zimmer Biomet G7 DM结构的患者,随访至少1年。术后6周前及术后1年和2年测定血清钴、铬和钛水平。如果以前的实验室升高,则获得五年的实验室。结果术后0 ~ 6周,4/26例患者钴水平轻度升高(1 ~ 2.8 μg/L), 2/26例患者铬水平轻度升高(1.6、2.0 μg/L)。19例患者1年或2年钴水平均未升高,4/19例患者1年铬水平轻度升高(1.1 ~ 1.3 μg/L), 2年略有下降(1 ~ 1.4 μg/L)。在任何时间点均没有患者金属离子水平超过5 μg/L的初始早期阈值。没有患者出现症状,也没有指示或获得mri。在这一系列特定的模块化糖尿病系统中,4例患者早期轻度升高的钴水平随后全部恢复正常。4名患者的铬含量在第2年轻度升高。虽然这些发现在短期内是令人放心的,因为轻度升高的铬(2 μg/L)与临床毒性无关,但需要进一步的随访来确定这种特定模块化DM植入物的长期安全性和有效性。
{"title":"Reassuring early serum metal ion levels with a specific modular dual mobility system","authors":"Michael J. Archibeck,&nbsp;Brenna E. Blackburn,&nbsp;Claire R. Kapron,&nbsp;Lucas A. Anderson,&nbsp;Jeremy M. Gililland,&nbsp;Christopher L. Peters,&nbsp;Christopher E. Pelt","doi":"10.1016/j.jor.2026.02.012","DOIUrl":"10.1016/j.jor.2026.02.012","url":null,"abstract":"<div><h3>Introduction</h3><div>The popularity of modular dual mobility (MDM) acetabular components has increased. Concerns have been raised about the potential for corrosion related complications in these modular implants. The purpose of this study was to prospectively monitor serum ion levels in a series of patients with a modular dual mobility system.</div></div><div><h3>Methods</h3><div>Twenty-six patients with the Zimmer Biomet G7 DM construct were enrolled and followed for a minimum of one year. Serum cobalt, chromium, and titanium levels were obtained prior to six-weeks postoperatively and at one and two-years postoperatively. Five-year labs were obtained if previous labs were elevated.</div></div><div><h3>Results</h3><div>At 0-6 weeks postoperatively, 4/26 patients had mildly elevated cobalt levels (1-2.8 μg/L) and 2/26 had mildly elevated chromium levels (1.6, 2.0 μg/L). None of the 19 patients showed elevated cobalt levels at one or two years, while 4/19 reported mildly elevated chromium levels (1.1-1.3 μg/L) at one-year with a slight decrease (1-1.4 μg/L) at two-years. No patients at any time point had metal ion levels exceeding the initial early threshold of 5 μg/L. No patient was symptomatic and no MRIs were indicated or obtained.</div></div><div><h3>Discussion</h3><div>In this series of a specific modular DM system, the early mildly elevated cobalt levels in four patients all subsequently normalized. Chromium was mildly elevated in four patients through year two. While these findings are reassuring in the short term as mildly elevated chromium (&lt;2 μg/L) has not been associated with clinical toxicity, additional follow-up is needed to establish the long-term safety and efficacy of this specific modular DM implant.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 6-11"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated lateral release or lateral lengthening for non-instability indications: A systematic review 非失稳适应症的孤立侧位松解或侧位延长:一项系统回顾
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-03 DOI: 10.1016/j.jor.2026.02.020
Cailan L. Feingold , Eric H. Lin , Andrew B. Barcenas , Brandon A. Young , Ji S. Chin , Austin V. Stone , Joseph N. Liu

Purpose

Isolated lateral release (LR) and lateral lengthening (LL) may have a role in the management of knee pain without instability, but these indications have not been clearly defined. This study sought to evaluate the use of isolated lateral release and lateral lengthening for non-instability indications of the knee.

Methods

PubMed, Embase, and Web of Science were queried for terms related to lateral release and lateral lengthening of the knee. Included studies investigated isolated LR or LL as an intervention for non-patellofemoral instability indications of the knee that were published in English and in peer-reviewed journals. Studies were excluded if they investigated LR or LL for patellofemoral instability or during total knee arthroplasty, published before 2000, systematic reviews, biomechanical studies, and case reports. Surgery indications, patient demographics, patient-reported outcome measures (PROMs), complications and subsequent surgeries, were collected.

Results

Seven studies with 404 patients were included, 4 of which investigated LR/LL for lateral patellar compression syndrome (LPCS), 1 for anterior knee pain, 1 for patellofemoral arthritis, and 1 for patellofemoral arthrofibrosis following anterior cruciate ligament reconstruction. All seven studies reported significant improvements in PROMs and clinical outcomes, regardless of indication. The most common complications were postoperative hemarthrosis, medial patellar instability, and fibrosis.

Conclusion

Isolated LR and LL are viable options for the management of LPCS, anterior knee pain, and postoperative patellofemoral arthrofibrosis that lead to improvements in PROMs. Medial patellar instability is a feared complication of LR/LL but appears to be more likely in patients undergoing LR.

Study design

Systematic Review; LOE IV
目的:孤立的外侧松解术(LR)和外侧延长术(LL)可能在无不稳定性的膝关节疼痛治疗中发挥作用,但这些适应症尚未明确定义。本研究旨在评估孤立的外侧松解和外侧延长在膝关节非不稳定指征中的应用。方法查询spubmed、Embase和Web of Science中与膝关节外侧松解和外侧延长相关的术语。纳入的研究调查了孤立的LR或LL作为膝关节非髌骨不稳指征的干预措施,这些研究已在英文和同行评审期刊上发表。在2000年之前发表的系统综述、生物力学研究和病例报告中,如果研究髌骨不稳定或全膝关节置换术期间的LR或LL,则排除。收集手术指征、患者人口统计学、患者报告的结果测量(PROMs)、并发症和随后的手术。结果纳入7项研究,共404例患者,其中4项研究LR/LL治疗外侧髌骨压迫综合征(LPCS), 1项治疗膝关节前侧疼痛,1项治疗髌股关节炎,1项治疗前交叉韧带重建后髌股关节纤维化。所有七项研究都报告了PROMs和临床结果的显著改善,无论适应症如何。最常见的并发症是术后关节出血、内侧髌骨不稳定和纤维化。结论孤立的LR和LL是治疗LPCS、膝关节前侧疼痛和术后髌股关节纤维化的可行选择,可改善PROMs。内侧髌骨不稳定是LR/LL的一种可怕的并发症,但在LR患者中似乎更容易发生。研究设计;系统评价;爱情第四
{"title":"Isolated lateral release or lateral lengthening for non-instability indications: A systematic review","authors":"Cailan L. Feingold ,&nbsp;Eric H. Lin ,&nbsp;Andrew B. Barcenas ,&nbsp;Brandon A. Young ,&nbsp;Ji S. Chin ,&nbsp;Austin V. Stone ,&nbsp;Joseph N. Liu","doi":"10.1016/j.jor.2026.02.020","DOIUrl":"10.1016/j.jor.2026.02.020","url":null,"abstract":"<div><h3>Purpose</h3><div>Isolated lateral release (LR) and lateral lengthening (LL) may have a role in the management of knee pain without instability, but these indications have not been clearly defined. This study sought to evaluate the use of isolated lateral release and lateral lengthening for non-instability indications of the knee.</div></div><div><h3>Methods</h3><div>PubMed, Embase, and Web of Science were queried for terms related to lateral release and lateral lengthening of the knee. Included studies investigated isolated LR or LL as an intervention for non-patellofemoral instability indications of the knee that were published in English and in peer-reviewed journals. Studies were excluded if they investigated LR or LL for patellofemoral instability or during total knee arthroplasty, published before 2000, systematic reviews, biomechanical studies, and case reports. Surgery indications, patient demographics, patient-reported outcome measures (PROMs), complications and subsequent surgeries, were collected.</div></div><div><h3>Results</h3><div>Seven studies with 404 patients were included, 4 of which investigated LR/LL for lateral patellar compression syndrome (LPCS), 1 for anterior knee pain, 1 for patellofemoral arthritis, and 1 for patellofemoral arthrofibrosis following anterior cruciate ligament reconstruction. All seven studies reported significant improvements in PROMs and clinical outcomes, regardless of indication. The most common complications were postoperative hemarthrosis, medial patellar instability, and fibrosis.</div></div><div><h3>Conclusion</h3><div>Isolated LR and LL are viable options for the management of LPCS, anterior knee pain, and postoperative patellofemoral arthrofibrosis that lead to improvements in PROMs. Medial patellar instability is a feared complication of LR/LL but appears to be more likely in patients undergoing LR.</div></div><div><h3>Study design</h3><div>Systematic Review; LOE IV</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 62-66"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of combat sport-related fractures treated in United States emergency departments 美国急诊科治疗格斗运动相关骨折的流行病学
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jor.2026.02.047
Zayd Chishti , Albert Brotgandel , Carson Balen , Rebecca Lipscomb , D. Trey Remaley , John Kiel

Objectives

To determine the incidence and demographic characteristics of combat sport-related fractures treated in U.S. emergency departments and compare demographic variables, injury characteristics, and disposition among boxing-, wrestling-, and martial arts (MA)-related fractures.

Methods

The National Electronic Injury Surveillance System (NEISS) was queried for boxing, wrestling, and MA-related fractures from 2014 to 2023. Analyses included descriptive statistics and comparative tests (chi-square, Fisher's, Mann-Whitney U, Kruskal-Wallis).

Results

Of 22,233 combat sport-related injuries, 4391 (19.7%) were fractures: 929 boxing (21.2%), 1938 wrestling (44.1%), and 1524 MA (34.7%). NEISS weighted estimates correspond to 80,182 injuries and 14,555 fractures annually. Fractures comprised the greatest proportion of total injuries in boxing (21.6%) (p = 0.002), and the mean age at the time of fracture was highest in the boxing group (25.18 ± 11.49 years) (p < 0.001). Boxing fractures most often involved the hand (50.4%), wrestling the shoulder (15.7%), and MA the toes (15.9%) (p < 0.001). Pediatric patients (<18 years) represented 64.9% of fractures, most commonly lower arm (15.2%), while adults most often sustained hand fractures (31.0%) (p < 0.001). Wrestling (88.2%) and MA (56.3%) fractures occurred mainly in pediatric patients, whereas boxing fractures were more frequent in adults (69.6%) (p < 0.001). Males accounted for 85.2% of fractures, most often involving the hand (16.7%), while females most frequently sustained shoulder fractures (14.5%) (p < 0.001). Patients with boxing fractures were the most likely to be treated and released (96.3%) (p < 0.001).

Conclusion

Combat sport-related fractures show distinct patterns by sport, age, and sex, insights that can inform targeted injury prevention and safety strategies.
目的确定在美国急诊科治疗的格斗运动相关骨折的发生率和人口统计学特征,并比较拳击、摔跤和武术(MA)相关骨折的人口统计学变量、损伤特征和处置。方法对2014 - 2023年美国国家电子损伤监测系统(NEISS)的拳击、摔跤和ma相关骨折进行查询。分析包括描述性统计和比较检验(卡方、Fisher’s、Mann-Whitney U、Kruskal-Wallis)。结果22233例格斗运动损伤中,骨折4391例(19.7%),拳击929例(21.2%),摔跤1938例(44.1%),MA 1524例(34.7%)。NEISS加权估计相当于每年80,182例损伤和14,555例骨折。拳击组骨折发生率最高(21.6%)(p = 0.002),骨折发生年龄以拳击组最高(25.18±11.49岁)(p < 0.001)。拳击骨折最常发生在手部(50.4%)、摔跤肩部(15.7%)和脚趾(15.9%)(p < 0.001)。儿童患者(18岁)占骨折的64.9%,最常见的是下臂(15.2%),而成人最常见的是手部骨折(31.0%)(p < 0.001)。摔跤骨折(88.2%)和MA骨折(56.3%)主要发生在儿童患者中,而拳击骨折在成人中更为常见(69.6%)(p < 0.001)。男性骨折占85.2%,最常见的是手部骨折(16.7%),而女性最常见的是肩部骨折(14.5%)(p < 0.001)。拳型骨折患者的治疗和释放率最高(96.3%)(p < 0.001)。结论:搏击性运动相关骨折在运动、年龄和性别方面表现出不同的模式,可以为有针对性的损伤预防和安全策略提供信息。
{"title":"Epidemiology of combat sport-related fractures treated in United States emergency departments","authors":"Zayd Chishti ,&nbsp;Albert Brotgandel ,&nbsp;Carson Balen ,&nbsp;Rebecca Lipscomb ,&nbsp;D. Trey Remaley ,&nbsp;John Kiel","doi":"10.1016/j.jor.2026.02.047","DOIUrl":"10.1016/j.jor.2026.02.047","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the incidence and demographic characteristics of combat sport-related fractures treated in U.S. emergency departments and compare demographic variables, injury characteristics, and disposition among boxing-, wrestling-, and martial arts (MA)-related fractures.</div></div><div><h3>Methods</h3><div>The National Electronic Injury Surveillance System (NEISS) was queried for boxing, wrestling, and MA-related fractures from 2014 to 2023. Analyses included descriptive statistics and comparative tests (chi-square, Fisher's, Mann-Whitney U, Kruskal-Wallis).</div></div><div><h3>Results</h3><div>Of 22,233 combat sport-related injuries, 4391 (19.7%) were fractures: 929 boxing (21.2%), 1938 wrestling (44.1%), and 1524 MA (34.7%). NEISS weighted estimates correspond to 80,182 injuries and 14,555 fractures annually. Fractures comprised the greatest proportion of total injuries in boxing (21.6%) (p = 0.002), and the mean age at the time of fracture was highest in the boxing group (25.18 ± 11.49 years) (p &lt; 0.001). Boxing fractures most often involved the hand (50.4%), wrestling the shoulder (15.7%), and MA the toes (15.9%) (p &lt; 0.001). Pediatric patients (&lt;18 years) represented 64.9% of fractures, most commonly lower arm (15.2%), while adults most often sustained hand fractures (31.0%) (p &lt; 0.001). Wrestling (88.2%) and MA (56.3%) fractures occurred mainly in pediatric patients, whereas boxing fractures were more frequent in adults (69.6%) (p &lt; 0.001). Males accounted for 85.2% of fractures, most often involving the hand (16.7%), while females most frequently sustained shoulder fractures (14.5%) (p &lt; 0.001). Patients with boxing fractures were the most likely to be treated and released (96.3%) (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Combat sport-related fractures show distinct patterns by sport, age, and sex, insights that can inform targeted injury prevention and safety strategies.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 106-112"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sociodemographic variables are rarely reported in randomized controlled trials investigating posterior spinal fusion for adult spinal deformity: A systematic review 调查成人脊柱畸形后路脊柱融合术的随机对照试验中很少报道社会人口统计学变量
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jor.2026.02.016
Kenneth T. Nguyen , Erin L. Brown , Bhavesh R. Koppala , Daman P. Dhunna , Neil Samant , Hanna House , Alexander Kuzma , Nikolas Baksh

Purpose

Adult spinal deformity (ASD) affects approximately 68% of patients over age 65 and can significantly reduce quality of life. Posterior spinal fusion (PSF) is a common corrective procedure, but sociodemographic disparities may influence outcomes. This study evaluates the frequency of sociodemographic variable reporting in randomized controlled trials (RCTs) investigating PSF for ASD, hypothesizing significant underreporting and their potential as modifiable confounders of treatment outcomes.

Methods

A systematic literature review was conducted on April 15, 2024, in accordance with PRISMA guidelines using PubMed, Embase, and Scopus to identify RCTs on ASD and PSF. Studies were included if they were full-length RCTs and excluded if non-English, unavailable, cadaveric, technical, or non-RCT. Two spine surgeons independently screened studies, with a third reviewer resolving disagreements. Data on demographic and socioeconomic variables were extracted. Descriptive statistics and chi-squared or Fisher's exact tests (P < 0.05) were used for analysis.

Results

The search yielded 32 studies; after removing duplicates and ineligible studies, five RCTs published between 2008 and 2020 met inclusion criteria. All reported age and sex (100%), but none included race, ethnicity, employment, education, housing, or income, and only one reported insurance status (20%). Demographic and socioeconomic variables were significantly underreported compared to age and sex (P < 0.001), with no differences by journal or publication year.

Conclusion

Age and sex were consistently reported in ASD RCTs, but broader sociodemographic data were largely absent. Future trials should include these variables to better understand disparities and improve equitable care for ASD patients.
目的:成人脊柱畸形(ASD)影响约68%的65岁以上患者,并可显著降低生活质量。后路脊柱融合(PSF)是一种常见的矫正手术,但社会人口差异可能会影响结果。本研究评估了随机对照试验(RCTs)中调查PSF对ASD的影响的社会人口学变量报告的频率,假设了显著的低报,以及它们作为治疗结果可改变的混杂因素的可能性。方法根据PRISMA指南,于2024年4月15日使用PubMed、Embase和Scopus进行系统文献综述,筛选ASD和PSF相关的随机对照试验。纳入全长rct的研究,排除非英语、不可获得、尸体、技术或非rct的研究。两位脊柱外科医生独立筛选研究,由第三位审稿人解决分歧。提取了人口统计和社会经济变量的数据。采用描述性统计和卡方检验或Fisher精确检验(P < 0.05)进行分析。结果共检索到32项研究;在剔除重复和不合格的研究后,2008年至2020年间发表的5项随机对照试验符合纳入标准。所有报告的年龄和性别(100%),但没有一个包括种族、民族、就业、教育、住房或收入,只有一个报告了保险状况(20%)。与年龄和性别相比,人口统计学和社会经济变量被显著低估(P < 0.001),不同期刊或出版年份之间没有差异。结论:年龄和性别在ASD随机对照试验中被一致报道,但更广泛的社会人口学数据在很大程度上缺失。未来的试验应该包括这些变量,以更好地了解差异并改善对ASD患者的公平护理。
{"title":"Sociodemographic variables are rarely reported in randomized controlled trials investigating posterior spinal fusion for adult spinal deformity: A systematic review","authors":"Kenneth T. Nguyen ,&nbsp;Erin L. Brown ,&nbsp;Bhavesh R. Koppala ,&nbsp;Daman P. Dhunna ,&nbsp;Neil Samant ,&nbsp;Hanna House ,&nbsp;Alexander Kuzma ,&nbsp;Nikolas Baksh","doi":"10.1016/j.jor.2026.02.016","DOIUrl":"10.1016/j.jor.2026.02.016","url":null,"abstract":"<div><h3>Purpose</h3><div>Adult spinal deformity (ASD) affects approximately 68% of patients over age 65 and can significantly reduce quality of life. Posterior spinal fusion (PSF) is a common corrective procedure, but sociodemographic disparities may influence outcomes. This study evaluates the frequency of sociodemographic variable reporting in randomized controlled trials (RCTs) investigating PSF for ASD, hypothesizing significant underreporting and their potential as modifiable confounders of treatment outcomes.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted on April 15, 2024, in accordance with PRISMA guidelines using PubMed, Embase, and Scopus to identify RCTs on ASD and PSF. Studies were included if they were full-length RCTs and excluded if non-English, unavailable, cadaveric, technical, or non-RCT. Two spine surgeons independently screened studies, with a third reviewer resolving disagreements. Data on demographic and socioeconomic variables were extracted. Descriptive statistics and chi-squared or Fisher's exact tests (P &lt; 0.05) were used for analysis.</div></div><div><h3>Results</h3><div>The search yielded 32 studies; after removing duplicates and ineligible studies, five RCTs published between 2008 and 2020 met inclusion criteria. All reported age and sex (100%), but none included race, ethnicity, employment, education, housing, or income, and only one reported insurance status (20%). Demographic and socioeconomic variables were significantly underreported compared to age and sex (P &lt; 0.001), with no differences by journal or publication year.</div></div><div><h3>Conclusion</h3><div>Age and sex were consistently reported in ASD RCTs, but broader sociodemographic data were largely absent. Future trials should include these variables to better understand disparities and improve equitable care for ASD patients.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 1-5"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical outcomes and structural integrity after arthroscopic partial repair with patch augmentation for large to massive rotator cuff tears 关节镜下补片增强部分修复大到大块肩袖撕裂后的临床结果和结构完整性
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-09 DOI: 10.1016/j.jor.2026.02.037
Chang Hee Baek, Bo Taek Kim, Jung Gon Kim, Chaemoon Lim, Seung Jin Kim

Introduction

Complete anatomic repair of large to massive rotator cuff tears (RCTs) is often not feasible because of tendon retraction, poor tissue quality, and advanced muscle degeneration. This study evaluates short-term clinical outcomes, complications, and postoperative structural integrity following arthroscopic partial rotator cuff repair with patch augmentation in patients with large to massive rotator cuff tears.

Methods

From May 2023 to December 2023, patients who underwent arthroscopic partial rotator cuff repair with patch augmentation for large to massive RCTS were retrospectively reviewed. Inclusion criteria were full-thickness supraspinatus tears with or without infraspinatus involvement, anteroposterior tear size >30 mm, and intraoperative confirmation that complete footprint coverage was not achievable. Exclusion criteria were loss to follow-up, prior shoulder instability surgery, and incomplete clinical data. Clinical outcomes were assessed preoperatively and at final follow-up using VAS pain, Constant, ASES, and SANE scores, range of motion (ROM), and forward elevation strength. Postoperative cuff integrity was evaluated with MRI, with subgroup analyses based on repair integrity.

Results

After exclusion of 16 patients, 90 patients were included, with a mean follow-up duration of 26.3 ± 2.1 months. Significant improvements were observed in pain, patient-reported outcome measures, ROM, and shoulder strength at final follow-up compared with preoperative values (all p < .001). Postoperative retear occurred in 18 patients (20.0%). Patients with intact repairs showed significantly superior pain relief, functional outcome scores, ROM, and strength compared with those who experienced retears (all p < .001). Other complications included shoulder stiffness in 8 patients (8.9%), infection in 2 patients (2.2%), and progression of glenohumeral arthritis in 3 patients (3.3%).

Conclusion

Arthroscopic partial repair with patch augmentation resulted in significant short-term improvements in pain, functional outcomes, ROM, and shoulder strength in patients with large to massive RCTs. Patients with intact repairs demonstrated superior clinical outcomes and achieved higher rates of clinically meaningful improvement compared with those in the retear group.

Study design

Case series; Level of evidence, IV.
完全性解剖修复大到大面积肩袖撕裂(rct)通常是不可行的,因为肌腱挛缩、组织质量差和晚期肌肉退变。本研究评估了大到大面积肩袖撕裂患者在关节镜下部分肩袖补片增强修复后的短期临床结果、并发症和术后结构完整性。方法回顾性分析2023年5月至2023年12月在大到大面积随机对照试验中行关节镜下部分肩袖补片修复术的患者。纳入标准是累及或不累及冈下肌的全层冈上肌撕裂,前后撕裂大小为30mm,术中确认无法完全覆盖足印。排除标准为无随访、既往肩部不稳定手术和临床资料不完整。临床结果在术前和最终随访时通过VAS疼痛、Constant、ASES和SANE评分、活动范围(ROM)和前仰强度进行评估。术后用MRI评估袖带完整性,并根据修复完整性进行亚组分析。结果排除16例患者后,纳入90例患者,平均随访26.3±2.1个月。与术前相比,最终随访时疼痛、患者报告的结果测量、ROM和肩部力量均有显著改善(均p <; 0.001)。术后复发18例(20.0%)。完整修复的患者与经历修复的患者相比,疼痛缓解、功能结局评分、ROM和力量都有显著的优势(均p <; 0.001)。其他并发症包括8例(8.9%)患者肩关节僵硬,2例(2.2%)患者感染,3例(3.3%)患者肩关节关节炎进展。结论:在大到大规模的随机对照试验中,关节镜局部修复与补片增强可显著改善患者的疼痛、功能结局、ROM和肩部力量。与retear组相比,完整修复的患者表现出更好的临床结果,取得了更高的临床有意义的改善率。研究设计:案例系列;证据水平,IV。
{"title":"Clinical outcomes and structural integrity after arthroscopic partial repair with patch augmentation for large to massive rotator cuff tears","authors":"Chang Hee Baek,&nbsp;Bo Taek Kim,&nbsp;Jung Gon Kim,&nbsp;Chaemoon Lim,&nbsp;Seung Jin Kim","doi":"10.1016/j.jor.2026.02.037","DOIUrl":"10.1016/j.jor.2026.02.037","url":null,"abstract":"<div><h3>Introduction</h3><div>Complete anatomic repair of large to massive rotator cuff tears (RCTs) is often not feasible because of tendon retraction, poor tissue quality, and advanced muscle degeneration. This study evaluates short-term clinical outcomes, complications, and postoperative structural integrity following arthroscopic partial rotator cuff repair with patch augmentation in patients with large to massive rotator cuff tears.</div></div><div><h3>Methods</h3><div>From May 2023 to December 2023, patients who underwent arthroscopic partial rotator cuff repair with patch augmentation for large to massive RCTS were retrospectively reviewed. Inclusion criteria were full-thickness supraspinatus tears with or without infraspinatus involvement, anteroposterior tear size &gt;30 mm, and intraoperative confirmation that complete footprint coverage was not achievable. Exclusion criteria were loss to follow-up, prior shoulder instability surgery, and incomplete clinical data. Clinical outcomes were assessed preoperatively and at final follow-up using VAS pain, Constant, ASES, and SANE scores, range of motion (ROM), and forward elevation strength. Postoperative cuff integrity was evaluated with MRI, with subgroup analyses based on repair integrity.</div></div><div><h3>Results</h3><div>After exclusion of 16 patients, 90 patients were included, with a mean follow-up duration of 26.3 ± 2.1 months. Significant improvements were observed in pain, patient-reported outcome measures, ROM, and shoulder strength at final follow-up compared with preoperative values (all p &lt; .001). Postoperative retear occurred in 18 patients (20.0%). Patients with intact repairs showed significantly superior pain relief, functional outcome scores, ROM, and strength compared with those who experienced retears (all p &lt; .001). Other complications included shoulder stiffness in 8 patients (8.9%), infection in 2 patients (2.2%), and progression of glenohumeral arthritis in 3 patients (3.3%).</div></div><div><h3>Conclusion</h3><div>Arthroscopic partial repair with patch augmentation resulted in significant short-term improvements in pain, functional outcomes, ROM, and shoulder strength in patients with large to massive RCTs. Patients with intact repairs demonstrated superior clinical outcomes and achieved higher rates of clinically meaningful improvement compared with those in the retear group.</div></div><div><h3>Study design</h3><div>Case series; Level of evidence, IV.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 148-153"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemiarthroplasty for unstable intertrochanteric hip fractures: A systematic review and meta-analysis 半关节置换术治疗不稳定股骨粗隆间骨折:系统回顾和荟萃分析
IF 1.5 Q3 ORTHOPEDICS Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.jor.2026.01.019
Zeremy Tang , Ryan Wai Keong Loke , Jonathan Jia En Boey , Alexander Xi Xuan Ang , Darren Keng Jin Tay

Background

Unstable intertrochanteric hip fractures remain prevalent in the elderly with impacts on function and quality of life. Both hemiarthroplasty and internal fixation methods have been surgical options, with consensus yet to be reached on the optimal approach. This review compares intraoperative and postoperative clinical outcomes between the two techniques.

Methods

Systematic review and meta-analysis was conducted, searching four databases for studies on patients who received either internal fixation (IF) or hemiarthroplasty (HA) for unstable intertrochanteric hip fractures. The primary outcome was Harris Hip Score (HHS), with secondary outcomes of intraoperative and postoperative clinical findings. Intra-study risk of bias was graded using ROBINS-I and Cochrane Risk-of-Bias tool, with assessment of evidence certainty using the GRADE approach.

Results

HHS for HA was significantly greater at 3 and 6-month post-operation compared to IF, with a weighted mean difference of 12.5 (95% CI: 8.6-16.4) and 5.3 (95% CI: 2.9-7.7) respectively. Furthermore, HA's relative risk (RR) of reoperations was lower at 0.6 (95% CI: 0.3-1.0), RR of nonunion of fractures was lower at 0.5 (95% CI: 0.3 - 0.9) and RR of prosthesis failure lower at 0.4 (95% CI: 0.2-1.0). Intraoperatively, HA had a longer operation time by 12.2 min (95% CI: 6.6-17.9) and greater blood loss of 152.8 mL (95% CI: 108.1-197.6). Post-operatively, HA had a higher RR of 1-year mortality rate at 1.6 (95% CI: 1.2 - 2.1) and higher RR of SSI at 1.4 (95% CI: 1.0-2.1). Otherwise, there is no difference in post-operative complications of deep vein thrombosis, limb length deformity and periprosthetic fractures.

Conclusion

HA provided superior early functional outcome and a reduced relative risk of mechanical complications at the cost of increased intraoperative burden, higher early post-operative mortality and SSI risk. IF hence offers lowered intraoperative stress and reduced post-operative morbidity. Surgical choice should ultimately be individualised based on patient priorities and risk profile.
背景:不稳定性髋粗隆间骨折在老年人中仍然普遍存在,影响了功能和生活质量。半关节置换术和内固定方法都是手术选择,但对于最佳方法尚未达成共识。这篇综述比较了两种技术的术中和术后临床结果。方法系统回顾和荟萃分析,检索4个数据库,纳入不稳定股骨粗隆间髋部骨折患者接受内固定(IF)或半关节置换术(HA)的研究。主要终点是Harris髋关节评分(HHS),次要终点是术中和术后临床表现。使用ROBINS-I和Cochrane风险-偏倚工具对研究内偏倚风险进行分级,并使用GRADE方法评估证据确定性。结果HA术后3月和6月的shhs明显高于IF,加权平均差值分别为12.5 (95% CI: 8.6-16.4)和5.3 (95% CI: 2.9-7.7)。此外,HA的再手术相对危险度(RR)较低,为0.6 (95% CI: 0.3-1.0),骨折不愈合的相对危险度(RR)较低,为0.5 (95% CI: 0.3- 0.9),假体失败的相对危险度(RR)较低,为0.4 (95% CI: 0.2-1.0)。术中HA手术时间延长12.2 min (95% CI: 6.6 ~ 17.9),出血量增加152.8 mL (95% CI: 108.1 ~ 197.6)。术后HA的1年死亡率RR为1.6 (95% CI: 1.2 -2.1), SSI的RR为1.4 (95% CI: 1.0-2.1)。除此之外,术后并发症深静脉血栓形成、肢体长度畸形和假体周围骨折无差异。结论ha提供了良好的早期功能结局,降低了机械并发症的相对风险,但代价是增加了术中负担,增加了术后早期死亡率和SSI风险。因此,IF降低了术中压力,降低了术后发病率。手术选择最终应根据患者的优先级和风险概况进行个体化。
{"title":"Hemiarthroplasty for unstable intertrochanteric hip fractures: A systematic review and meta-analysis","authors":"Zeremy Tang ,&nbsp;Ryan Wai Keong Loke ,&nbsp;Jonathan Jia En Boey ,&nbsp;Alexander Xi Xuan Ang ,&nbsp;Darren Keng Jin Tay","doi":"10.1016/j.jor.2026.01.019","DOIUrl":"10.1016/j.jor.2026.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Unstable intertrochanteric hip fractures remain prevalent in the elderly with impacts on function and quality of life. Both hemiarthroplasty and internal fixation methods have been surgical options, with consensus yet to be reached on the optimal approach. This review compares intraoperative and postoperative clinical outcomes between the two techniques.</div></div><div><h3>Methods</h3><div>Systematic review and meta-analysis was conducted, searching four databases for studies on patients who received either internal fixation (IF) or hemiarthroplasty (HA) for unstable intertrochanteric hip fractures. The primary outcome was Harris Hip Score (HHS), with secondary outcomes of intraoperative and postoperative clinical findings. Intra-study risk of bias was graded using ROBINS-I and Cochrane Risk-of-Bias tool, with assessment of evidence certainty using the GRADE approach.</div></div><div><h3>Results</h3><div>HHS for HA was significantly greater at 3 and 6-month post-operation compared to IF, with a weighted mean difference of 12.5 (95% CI: 8.6-16.4) and 5.3 (95% CI: 2.9-7.7) respectively. Furthermore, HA's relative risk (RR) of reoperations was lower at 0.6 (95% CI: 0.3-1.0), RR of nonunion of fractures was lower at 0.5 (95% CI: 0.3 - 0.9) and RR of prosthesis failure lower at 0.4 (95% CI: 0.2-1.0). Intraoperatively, HA had a longer operation time by 12.2 min (95% CI: 6.6-17.9) and greater blood loss of 152.8 mL (95% CI: 108.1-197.6). Post-operatively, HA had a higher RR of 1-year mortality rate at 1.6 (95% CI: 1.2 - 2.1) and higher RR of SSI at 1.4 (95% CI: 1.0-2.1). Otherwise, there is no difference in post-operative complications of deep vein thrombosis, limb length deformity and periprosthetic fractures.</div></div><div><h3>Conclusion</h3><div>HA provided superior early functional outcome and a reduced relative risk of mechanical complications at the cost of increased intraoperative burden, higher early post-operative mortality and SSI risk. IF hence offers lowered intraoperative stress and reduced post-operative morbidity. Surgical choice should ultimately be individualised based on patient priorities and risk profile.</div></div>","PeriodicalId":16633,"journal":{"name":"Journal of orthopaedics","volume":"75 ","pages":"Pages 73-81"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of orthopaedics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1