{"title":"Thianthrenium salts to arynes: base promoted C-N bond construction","authors":"Jinghui Lyu, Xianghao Zhang, zijin Luo, Yang Jiang, Kexue Xing, guofu Zhang, Chengrong Ding","doi":"10.1002/adsc.202400889","DOIUrl":null,"url":null,"abstract":"Amine compounds are widely found in natural products, pharmaceuticals, and pesticides. We propose a base-facilitated synthesis method of polysubstituted aromatic amines. A simple, rapid, plateau-utilization, and highly regioselective non-in-situ amination reaction was achieved by using aryl thianthrenium salt as the aryne precursor, and the arylynyl distortion induced by the substituents. This method provides new possibilities for organic synthesis.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"98 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/adsc.202400889","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Amine compounds are widely found in natural products, pharmaceuticals, and pesticides. We propose a base-facilitated synthesis method of polysubstituted aromatic amines. A simple, rapid, plateau-utilization, and highly regioselective non-in-situ amination reaction was achieved by using aryl thianthrenium salt as the aryne precursor, and the arylynyl distortion induced by the substituents. This method provides new possibilities for organic synthesis.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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