{"title":"Thianthrenium Salts to Arynes: Base Promoted C−N Bond Construction","authors":"Jinghui Lyu, Xianghao Zhang, Zijin Luo, Yang Jiang, Kexue Xing, Guofu Zhang, Chengrong Ding","doi":"10.1002/adsc.202400889","DOIUrl":null,"url":null,"abstract":"<p>Amines are widely found in natural products, drugs and pesticides. We have proposed a base-promoted method for synthesizing polysubstituted aromatic amines. The reaction does not necessitate the involvement of transition metals, provided that an equivalent base is employed. In this process, aryl thianthrenium salt serves as the precursor to arynes, which are subsequently distorted by the induction effect of different substituents. The attack of amine nucleophiles results in the formation of a series of multi-substituted aromatic amine products.</p>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 1","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.202400889","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Amines are widely found in natural products, drugs and pesticides. We have proposed a base-promoted method for synthesizing polysubstituted aromatic amines. The reaction does not necessitate the involvement of transition metals, provided that an equivalent base is employed. In this process, aryl thianthrenium salt serves as the precursor to arynes, which are subsequently distorted by the induction effect of different substituents. The attack of amine nucleophiles results in the formation of a series of multi-substituted aromatic amine products.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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