MAPbrain: a multi-omics atlas of the primate brain

IF 16.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nucleic Acids Research Pub Date : 2024-10-18 DOI:10.1093/nar/gkae911

Liangchen Zhuo, Mengdi Wang, Tingrui Song, Suijuan Zhong, Bo Zeng, Zeyuan Liu, Xin Zhou, Wei Wang, Qian Wu, Shunmin He, Xiaoqun Wang

{"title":"MAPbrain: a multi-omics atlas of the primate brain","authors":"Liangchen Zhuo, Mengdi Wang, Tingrui Song, Suijuan Zhong, Bo Zeng, Zeyuan Liu, Xin Zhou, Wei Wang, Qian Wu, Shunmin He, Xiaoqun Wang","doi":"10.1093/nar/gkae911","DOIUrl":null,"url":null,"abstract":"The brain is the central hub of the entire nervous system. Its development is a lifelong process guided by a genetic blueprint. Understanding how genes influence brain development is critical for deciphering the formation of human cognitive functions and the underlying mechanisms of neurological disorders. Recent advances in multi-omics techniques have now made it possible to explore these aspects comprehensively. However, integrating and analyzing extensive multi-omics data presents significant challenges. Here, we introduced MAPbrain (http://bigdata.ibp.ac.cn/mapBRAIN/), a multi-omics atlas of the primate brain. This repository integrates and normalizes both our own lab's published data and publicly available multi-omics data, encompassing 21 million brain cells from 38 key brain regions and 436 sub-regions across embryonic and adult stages, with 164 time points in humans and non-human primates. MAPbrain offers a unique, robust, and interactive platform that includes transcriptomics, epigenomics, and spatial transcriptomics data, facilitating a comprehensive exploration of brain development. The platform enables the exploration of cell type- and time point-specific markers, gene expression comparison between brain regions and species, joint analyses across transcriptome and epigenome, and navigation of cell types across species, brain regions, and development stages. Additionally, MAPbrain provides an online integration module for users to navigate and analyze their own data within the platform.","PeriodicalId":19471,"journal":{"name":"Nucleic Acids Research","volume":null,"pages":null},"PeriodicalIF":16.6000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic Acids Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/nar/gkae911","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The brain is the central hub of the entire nervous system. Its development is a lifelong process guided by a genetic blueprint. Understanding how genes influence brain development is critical for deciphering the formation of human cognitive functions and the underlying mechanisms of neurological disorders. Recent advances in multi-omics techniques have now made it possible to explore these aspects comprehensively. However, integrating and analyzing extensive multi-omics data presents significant challenges. Here, we introduced MAPbrain (http://bigdata.ibp.ac.cn/mapBRAIN/), a multi-omics atlas of the primate brain. This repository integrates and normalizes both our own lab's published data and publicly available multi-omics data, encompassing 21 million brain cells from 38 key brain regions and 436 sub-regions across embryonic and adult stages, with 164 time points in humans and non-human primates. MAPbrain offers a unique, robust, and interactive platform that includes transcriptomics, epigenomics, and spatial transcriptomics data, facilitating a comprehensive exploration of brain development. The platform enables the exploration of cell type- and time point-specific markers, gene expression comparison between brain regions and species, joint analyses across transcriptome and epigenome, and navigation of cell types across species, brain regions, and development stages. Additionally, MAPbrain provides an online integration module for users to navigate and analyze their own data within the platform.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

MAPbrain：灵长类动物大脑多组学图谱

大脑是整个神经系统的中枢。大脑的发育是一个由基因蓝图引导的终身过程。了解基因如何影响大脑发育，对于破译人类认知功能的形成和神经系统疾病的内在机制至关重要。多组学技术的最新进展使得全面探索这些方面成为可能。然而，整合和分析大量多组学数据是一项重大挑战。在这里，我们介绍了灵长类动物大脑多组学图谱 MAPbrain (http://bigdata.ibp.ac.cn/mapBRAIN/)。该资源库整合并规范化了我们实验室已发表的数据和公开的多组学数据，涵盖了人类和非人灵长类胚胎期和成年期的38个关键脑区和436个亚区的2100万个脑细胞，以及164个时间点。MAPbrain 提供了一个独特、强大和互动的平台，其中包括转录组学、表观基因组学和空间转录组学数据，有助于对大脑发育进行全面探索。通过该平台可以探索细胞类型和时间点特异性标记物，比较不同脑区和物种的基因表达，联合分析转录组和表观基因组，以及跨物种、脑区和发育阶段的细胞类型导航。此外，MAPbrain 还提供了一个在线集成模块，供用户在平台内浏览和分析自己的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.