Xiuyuan Yao, Linyao Wang, Jie Luo, Chuyan Zhang, Yongxin Li
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引用次数: 0
Abstract
With the continuous development of DNA nanotechnology, DNA walkers have attracted increased attention because of their autonomous and progressive walking along predesigned tracks. Compared with the traditional DNA walkers, the emerged multipedal DNA walkers showed their special charm with sustainable walking capability, higher reaction efficiency, expanded walking region, and improved amplification capability. Consequently, multipedal DNA walkers have developed rapidly and shown potential in biosensing applications. Hence, in this review, we make a comprehensive representation of the engineering strategy of multipedal DNA walkers, which focused on the design of multiple walking strands as well as the construction of tracks and driving forces. Meanwhile, the application of multipedal DNA walkers in biosensors has been thoroughly described according to the type of biosensing signal readout. By illustrating some representative works, we also summarized the merits and challenges of multipedal DNA walker-based biosensors and offered a deep discussion of the latest progress and future.
随着DNA纳米技术的不断发展，DNA步行器因其可沿着预先设计的轨道自主、渐进地行走而受到越来越多的关注。与传统的 DNA 步行器相比，新出现的多级 DNA 步行器显示出其独特的魅力，具有可持续行走能力、更高的反应效率、更大的行走区域和更强的扩增能力。因此，多极 DNA 步行器得到了快速发展，并在生物传感应用中展现出巨大潜力。因此，在这篇综述中，我们全面介绍了多足 DNA 步行器的工程设计策略，主要集中在多条步行链的设计以及轨道和驱动力的构建上。同时，根据生物传感信号读出的类型，全面阐述了多向DNA步行器在生物传感器中的应用。通过展示一些代表性的作品，我们还总结了基于多极DNA步行器的生物传感器的优点和挑战，并对最新进展和未来进行了深入探讨。
期刊介绍：
ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.
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