{"title":"Copper-Based Electrochemical Sensor Derived from Thiosemicarbazide for Selective Detection of Neurotransmitter Dopamine","authors":"Shubham Jaiswal, Suryansh Chandra, Jyoti Prajapati, Ida Tiwari, Manoj Kumar Bharty","doi":"10.1021/acs.langmuir.4c02438","DOIUrl":null,"url":null,"abstract":"This paper presents the synthesis of the ligand 1-picolinoyl-4-cyclohexyl-3-thiosemicarbazide (H<sub>2</sub>pctc) and new metal complexes [Ni(Hpctc)<sub>2</sub>] (<b>1</b>), [Cu(Hpctc)Cl] (<b>2</b>), and [Cd(Hpctc)<sub>2</sub>] (<b>3</b>). The synthesized metal complexes were precisely characterized using single crystal X-ray diffraction (SC-XRD). In addition, complexes <b>1</b>–<b>3</b> were also characterized by UV–vis, fluorescence, and infrared spectroscopy. SC-XRD data confirmed the distorted octahedral geometry around the Ni(II) and Cd(II) centers and the distorted square planar geometry around the Cu(II) center. Data derived from the emission spectra depict that higher fluorescence intensity was exhibited by complexes <b>1</b>, <b>2</b>, and <b>3</b> in comparison to that of the free ligand H<sub>2</sub>pctc, and complex <b>3</b> showed the maximum intensity. Further, these metal complex-modified GCEs (glassy carbon electrodes) were utilized for electrochemical sensing of dopamine (DPM). The electrochemical studies of these complexes were performed using modified glassy carbon electrodes supported by electrical impedance spectroscopy (EIS) and cyclic voltammetry (CV) methods. In contrast to complexes <b>1</b> and <b>3</b>, complex <b>2</b> is a superior electrode material with a high effective surface area for the electrochemical oxidation of DPM, according to the electrochemical response results. The derived sensor had a wide linear detection range of 1 to 1400 μM, an acceptable sensitivity of 0.01531 μA cm<sup>–2</sup> μM<sup>–1</sup>, and a low LOD of 0.38 μM. The proposed approach was free of the interfering effects of ascorbic acid, uric acid, aminophenol, and other substances. During the successive scans, no fouling of the electrode surface was observed. The proposed electrochemical sensor had excellent stability, sensitivity, and a low detection limit making it suitable for the analysis of a variety of real samples. Additionally, it was proven to be useful for analyzing biological fluids.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langmuir","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.langmuir.4c02438","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This paper presents the synthesis of the ligand 1-picolinoyl-4-cyclohexyl-3-thiosemicarbazide (H2pctc) and new metal complexes [Ni(Hpctc)2] (1), [Cu(Hpctc)Cl] (2), and [Cd(Hpctc)2] (3). The synthesized metal complexes were precisely characterized using single crystal X-ray diffraction (SC-XRD). In addition, complexes 1–3 were also characterized by UV–vis, fluorescence, and infrared spectroscopy. SC-XRD data confirmed the distorted octahedral geometry around the Ni(II) and Cd(II) centers and the distorted square planar geometry around the Cu(II) center. Data derived from the emission spectra depict that higher fluorescence intensity was exhibited by complexes 1, 2, and 3 in comparison to that of the free ligand H2pctc, and complex 3 showed the maximum intensity. Further, these metal complex-modified GCEs (glassy carbon electrodes) were utilized for electrochemical sensing of dopamine (DPM). The electrochemical studies of these complexes were performed using modified glassy carbon electrodes supported by electrical impedance spectroscopy (EIS) and cyclic voltammetry (CV) methods. In contrast to complexes 1 and 3, complex 2 is a superior electrode material with a high effective surface area for the electrochemical oxidation of DPM, according to the electrochemical response results. The derived sensor had a wide linear detection range of 1 to 1400 μM, an acceptable sensitivity of 0.01531 μA cm–2 μM–1, and a low LOD of 0.38 μM. The proposed approach was free of the interfering effects of ascorbic acid, uric acid, aminophenol, and other substances. During the successive scans, no fouling of the electrode surface was observed. The proposed electrochemical sensor had excellent stability, sensitivity, and a low detection limit making it suitable for the analysis of a variety of real samples. Additionally, it was proven to be useful for analyzing biological fluids.
期刊介绍:
Langmuir is an interdisciplinary journal publishing articles in the following subject categories:
Colloids: surfactants and self-assembly, dispersions, emulsions, foams
Interfaces: adsorption, reactions, films, forces
Biological Interfaces: biocolloids, biomolecular and biomimetic materials
Materials: nano- and mesostructured materials, polymers, gels, liquid crystals
Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry
Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals
However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do?
Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*.
This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).