Disorders of puberty and neurodevelopment: A shared etiology?

IF 4.1 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Annals of the New York Academy of Sciences Pub Date : 2024-10-21 DOI:10.1111/nyas.15246
Jordan E. Read, Alexandru Vasile-Tudorache, Angel Newsome, María José Lorente, Carmen Agustín-Pavón, Sasha R. Howard
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Abstract

The neuroendocrine control of puberty and reproduction is fascinatingly complex, with up- and down-regulation of key reproductive hormones during fetal, infantile, and later childhood periods that determine the correct function of the hypothalamic–pituitary–gonadal axis and the timing of puberty. Neuronal development is a vital element of these processes, and multiple conditions of disordered puberty and reproduction have their etiology in abnormal neuronal migration or function. Although there are numerous documented cases across multiple conditions wherein patients have both neurodevelopmental disorders and pubertal abnormalities, this has mostly been described ad hoc and the associations are not clearly documented. In this review, we aim to describe the overlap between these two groups of conditions and to increase awareness to ensure that puberty and reproductive function are carefully monitored in patients with neurodevelopmental conditions, and vice versa. Moreover, this commonality can be explored for clues about the disease mechanisms in these patient groups and provide new avenues for therapeutic interventions for affected individuals.

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青春期和神经发育障碍:共同的病因?
青春期和生殖的神经内分泌控制非常复杂,在胎儿期、婴儿期和儿童后期,关键生殖激素的上调和下调决定了下丘脑-垂体-性腺轴的正确功能和青春期的时间。神经元发育是这些过程中的重要因素,青春期和生殖紊乱的多种病因都与神经元迁移或功能异常有关。虽然有大量文献记载,在多种情况下,患者同时存在神经发育障碍和青春期异常,但这大多是临时描述的,其中的关联并没有明确的文献记载。在这篇综述中,我们旨在描述这两类疾病之间的重叠,并提高人们的认识,以确保对患有神经发育疾病的患者的青春期和生殖功能进行仔细监测,反之亦然。此外,这种共性还可以为这些患者群体的疾病机制提供线索,并为受影响个体的治疗干预提供新的途径。
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来源期刊
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences 综合性期刊-综合性期刊
CiteScore
11.00
自引率
1.90%
发文量
193
审稿时长
2-4 weeks
期刊介绍: Published on behalf of the New York Academy of Sciences, Annals of the New York Academy of Sciences provides multidisciplinary perspectives on research of current scientific interest with far-reaching implications for the wider scientific community and society at large. Each special issue assembles the best thinking of key contributors to a field of investigation at a time when emerging developments offer the promise of new insight. Individually themed, Annals special issues stimulate new ways to think about science by providing a neutral forum for discourse—within and across many institutions and fields.
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