Cascade [3 + 2] Annulation of 1,3-Dicarbonyl Compounds and Ethyl Secondary Amines for Pyrrole Synthesis via Poly C(sp3)–H Bond Functionalization

Abstract

The synthesis of polyfunctionalized pyrroles via the cascade reactions of 1,3-dicarbonyl compounds and two molecules of ethyl secondary amines has been realized via simple iodine catalysis in the presence of Dess–Martin periodinane (DMP). The formation of the target pyrrole products involves the formation of one new C–C and two new C–N bonds via the major functionalization of six C(sp³)–H bonds, presenting a highly novel and efficient synthetic protocol toward pyrrole scaffolds.