Shulei Hu , Yong Wang , Xiong Xie , Renwen Liang , Hong Liu , Jiang Wang
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引用次数: 0
Abstract
A ruthenium(II)‐catalyzed C−H acylmethylation of Trp‐containing peptides with α‐chloro ketones is reported here. This reaction features good C‐2 selectivity and chemoselectivity, making it suitable for late‐stage modification of Trp‐containing peptides. Low‐cost metal ruthenium as a catalyst enables the reaction to be conducted on a gram scale. This report also discusses the synthetic applications and presents a method to remove the pyridine directing group. In addition, a plausible mechanism of the C(2)−H acylmethylation reaction is proposed in this article.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
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