Synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral metal–organic framework and chiral molecularly imprinted polymer in capillary electrochromatography

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2024-10-22 DOI:10.1007/s00604-024-06773-8

Pandeng Miao, Dongyang Zhu, Shuaijing Du, Yingxiang Du

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Abstract

A capillary electrochromatography (CEC) synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral molecularly imprinted polymers (CMIPs) and chiral metal organic frameworks (CMOFs) was developed. Compared with CMIPs and CMOFs alone, the enantioseparation performance of ofloxacin (OFL) of the CEC with the novel nanomaterial as stationary phases was greatly improved. CMOFs with chiral recognition ability have synergize with CMIPs to greatly improve the chiral selectivity of the novel stationary phases in CEC. As a proof-of-concept demonstration, a coated capillary column was prepared by a sol–gel method using S-OFL (template), iron-based cyclodextrin MOF (Fe-CD-MOF, a CMOF), 3-aminopropyltriethoxysilane (functional monomer), and tetraethyl orthosilicate (cross-linking agent). Then, the newly constructed CEC system has excellent enantioseparation performance of OFL with a resolution of 3.92. Finally, computerized molecular docking revealed that the difference in the binding ability of Fe-CD-MOF to ofloxacin enantiomers was an important mechanism for CEC chiral separation. This innovative development of synergistic chiral stationary phases based on CMOFs and CMIPs creates a highly efficient potential direction for enantiomer separation.

Graphical Abstract

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毛细管电色谱中基于手性金属有机框架和手性分子印迹聚合物合成的新型纳米材料的协同对映体分离系统

研究人员开发了一种基于手性分子印迹聚合物（CMIPs）和手性金属有机框架（CMOFs）合成的新型纳米材料的毛细管电色谱（CEC）协同对映体分离系统。与单独使用 CMIPs 和 CMOFs 相比，以新型纳米材料为固定相的 CEC 对氧氟沙星（OFL）的对映分离性能大大提高。具有手性识别能力的 CMOFs 与 CMIPs 协同作用，大大提高了新型固定相在 CEC 中的手性选择性。作为概念验证，采用溶胶-凝胶法制备了涂覆毛细管柱，使用的材料包括 S-OFL（模板）、铁基环糊精 MOF（Fe-CD-MOF，一种 CMOF）、3-氨基丙基三乙氧基硅烷（功能单体）和正硅酸四乙酯（交联剂）。然后，新构建的 CEC 系统对 OFL 具有优异的对映体分离性能，分辨率达 3.92。最后，计算机分子对接显示，Fe-CD-MOF 与氧氟沙星对映体的结合能力差异是 CEC 手性分离的重要机制。这种基于 CMOFs 和 CMIPs 的协同手性固定相的创新发展为对映体的高效分离开辟了一个潜在的方向。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.