A nickel porphyrin-based covalent organic framework modified electrode for the electrochemical detection of acetaminophen†

Abstract

Covalent organic frameworks (COFs) can be rationally designed with functional organic ligands to improve the electrochemical responsiveness of the electrode toward certain medicinal compounds. In this study, we synthesized a COF-Ni electrocatalyst material, which is formed by covalent coupling of electron-rich 2,3,6,7-tetrakis (4-formylphenyl) tetrakis (4-imidazolyl) (TTF-4CHO) and hole-rich 5,10,15,20-tetrakis (4-aminophenyl) porphyrin nickel(II) (TAPP-Ni). The reasonable electron transfer path design, the large specific surface area of the COF and the physical properties of ordered nanopores, as well as the Ni–N₄ bond as a highly active catalytic center, allow the COF-Ni material modified electrode to exhibit excellent sensing performance for acetaminophen (ACOP). The detection limit for ACOP is as low as 47.6 nM, with a linear range of 1–1500 μM, which is better than for most of the reported sensors. With superior interference resistance and good stability performance, COF-Ni is a highly suited electrode modification material for real-world sample detection, which provided a new perspective for application of COF materials in drug analysis.