Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE): A randomized controlled trial.

IF 6.1 2区医学 Q1 ONCOLOGY Cancer Pub Date : 2024-10-21 DOI:10.1002/cncr.35540

Jennifer Brunet, Sitara Sharma, Kendra Zadravec, Monica Taljaard, Nathalie LeVasseur, Amirrtha Srikanthan, Kelcey A Bland, Elham Sabri, Barbara Collins, Sherri Hayden, Christine Simmons, Andra M Smith, Kristin L Campbell

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Abstract

Background: As the prevalence of chemotherapy-related cognitive impairment rises, investigation into treatment options is critical. The objectives of this study were to test the effects of an aerobic exercise intervention initiated during chemotherapy compared to usual care (wait list control condition) on (1) objectively measured cognitive function and self-reported cognitive function, as well as on (2) the impact of cognitive impairment on quality of life (QOL) postintervention (commensurate with chemotherapy completion).

Methods: The Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial was a two-arm, two-center randomized controlled trial conducted in Ottawa and Vancouver (Canada). Fifty-seven women (M_age, 48.8 ± 10 years) diagnosed with stage I-III breast cancer and awaiting chemotherapy were randomized to aerobic exercise initiated with chemotherapy (n_EX = 28) or usual care during chemotherapy with aerobic exercise after chemotherapy completion (n_UC = 29). The intervention lasted 12-24 weeks and consisted of supervised aerobic training and at-home exercise. The primary outcome was objective cognitive function measured via 13 neuropsychological tests (standardized to M ± SD, 0 ± 1); secondary outcomes of self-reported cognitive function and its impact on QOL were assessed via questionnaires. Data collected pre- and postintervention (the primary end point) were analyzed.

Results: Although no significant differences between groups were found for objective cognitive function outcomes postintervention after accounting for multiple testing, four of six self-reported cognitive function outcomes showed significant differences favoring the aerobic exercise group.

Conclusions: Among women initiating chemotherapy for breast cancer, aerobic exercise did not result in significant differences in objective cognitive function postintervention after chemotherapy completion; however, the results do support the use of this intervention for improving self-reported cognitive function and its impact on QOL.

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有氧运动与膀胱癌妇女的认知功能（ACTIVATE）：随机对照试验。

背景：随着化疗相关认知障碍发病率的上升，研究治疗方案至关重要。本研究的目的是测试化疗期间开始的有氧运动干预与常规护理（候补对照）相比，对（1）客观测量的认知功能和自我报告的认知功能，以及（2）干预后（与化疗完成时间一致）认知功能障碍对生活质量（QOL）的影响：有氧运动与前列腺癌女性患者认知功能（ACTIVATE）试验是一项双臂、双中心随机对照试验，分别在加拿大渥太华和温哥华进行。57名确诊为I-III期乳腺癌并等待化疗的妇女（年龄为48.8 ± 10岁）被随机分配到在化疗期间进行有氧运动（nEX = 28）或在化疗期间进行常规护理并在化疗结束后进行有氧运动（nUC = 29）。干预措施持续12-24周，包括有指导的有氧训练和居家锻炼。主要结果是通过 13 项神经心理学测试测量的客观认知功能（标准化为 M ± SD，0 ± 1）；次要结果是通过问卷评估自我报告的认知功能及其对 QOL 的影响。对干预前和干预后（主要终点）收集的数据进行了分析：结果：尽管经多重测试后，干预后客观认知功能结果在组间无明显差异，但在六项自我报告的认知功能结果中，有四项结果显示有氧运动组有明显优势：结论：在开始接受乳腺癌化疗的妇女中，有氧运动并没有在化疗结束后的干预后客观认知功能方面产生显著差异；但是，结果确实支持使用这种干预来改善自我报告的认知功能及其对 QOL 的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer 医学-肿瘤学

CiteScore

13.10

自引率

3.20%

发文量

480

审稿时长

2-3 weeks

期刊介绍： The CANCER site is a full-text, electronic implementation of CANCER, an Interdisciplinary International Journal of the American Cancer Society, and CANCER CYTOPATHOLOGY, a Journal of the American Cancer Society. CANCER publishes interdisciplinary oncologic information according to, but not limited to, the following disease sites and disciplines: blood/bone marrow; breast disease; endocrine disorders; epidemiology; gastrointestinal tract; genitourinary disease; gynecologic oncology; head and neck disease; hepatobiliary tract; integrated medicine; lung disease; medical oncology; neuro-oncology; pathology radiation oncology; translational research