Luteinizing hormone is independently associated with high-sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross-sectional study

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-10-22 DOI:10.1111/1753-0407.70005

Yahao Wang, Yixuan Li, Chuanfeng Liu, Yangang Wang, Yiming Li

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Abstract

Background

It is known that the risk of ischemic heart disease increases in patients with type 2 diabetes mellitus (T2DM). For female patients, the incidence of heart disease can be even greater after menopause, accompanied by dramatic changes in sex hormones. We investigated the correlations between sex hormones and markers of ischemic heart diseases in postmenopausal females with T2DM patients.

Methods

This cross-sectional study collected data from 324 hospitalized postmenopausal females with T2DM. Multiple linear regression analyses were conducted to determine the correlations between sex hormones and cardiac markers including high-sensitive cardiac troponin T (hs-cTnT) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels.

Results

Multiple linear regression analyses revealed that luteinizing hormone (LH) was positively and independently associated with hs-cTnT concentrations in postmenopausal females with T2DM (β = 0.189, p = 0.002). Postmenopausal females with T2DM and subclinical myocardial injury had higher LH levels than those without subclinical myocardial injury (29.67 vs. 25.08 mIU/mL, p < 0.001). A multivariate logistic regression analysis confirmed an independent and significant association between elevated LH and subclinical myocardial injury in postmenopausal females with T2DM (adjusted odds ratio [OR] = 1.077, 95% confidence interval [CI], 1.033–1.124; p < 0.001). As another gonadotropin, the follicle-stimulating hormone did not show independent correlations with hs-cTnT or NT-proBNP (p > 0.05). Neither estrogen nor testosterone was correlated with cardiac markers.

Conclusions

Elevated LH levels were positively and independently associated with increased hs-cTnT levels in postmenopausal women with T2DM. Our findings suggest that LH could serve as a potential marker for assessing the risk of subclinical myocardial injury in postmenopausal females with T2DM.

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绝经后 T2DM 患者的促黄体生成素与高敏心肌肌钙蛋白 T 升高独立相关：一项横断面研究。

背景：众所周知，2 型糖尿病（T2DM）患者罹患缺血性心脏病的风险会增加。对于女性患者来说，伴随着性激素的急剧变化，绝经后心脏病的发病率会更高。我们研究了绝经后女性 T2DM 患者性激素与缺血性心脏病标志物之间的相关性：这项横断面研究收集了 324 名患有 T2DM 的绝经后住院女性患者的数据。通过多元线性回归分析，确定性激素与高敏心肌肌钙蛋白 T（hs-cTnT）和脑钠肽 N 端前体（NT-proBNP）水平等心脏指标之间的相关性：多元线性回归分析显示，黄体生成素（LH）与T2DM绝经后女性的hs-cTnT浓度呈独立正相关（β = 0.189，P = 0.002）。患有 T2DM 和亚临床心肌损伤的绝经后女性的 LH 水平高于没有亚临床心肌损伤的女性（29.67 对 25.08 mIU/mL，P 0.05）。雌激素和睾酮均与心脏标志物无关：结论：在患有 T2DM 的绝经后妇女中，LH 水平升高与 hs-cTnT 水平升高呈独立正相关。我们的研究结果表明，LH可作为评估T2DM绝经后女性亚临床心肌损伤风险的潜在标志物。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.