Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling.

IF 3 3区 医学 Q2 BIOPHYSICS Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-17 DOI:10.1007/s10237-024-01884-w
Daniel Paukner, Jay D Humphrey, Christian J Cyron
{"title":"Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling.","authors":"Daniel Paukner, Jay D Humphrey, Christian J Cyron","doi":"10.1007/s10237-024-01884-w","DOIUrl":null,"url":null,"abstract":"<p><p>Constrained mixture models have successfully simulated many cases of growth and remodeling in soft biological tissues. So far, extensions of these models have been proposed to include either intracellular signaling or chemo-mechanical coupling on the organ-scale. However, no version of constrained mixture models currently exists that includes both aspects. Here, we propose such a version that resolves cellular signal processing by a set of logic-gated ordinary differential equations and captures chemo-mechanical interactions between cells by coupling a reaction-diffusion equation with the equations of nonlinear continuum mechanics. To demonstrate the potential of the model, we present 2 case studies within vascular solid mechanics: (i) the influence of angiotensin II on aortic growth and remodeling and (ii) the effect of communication between endothelial and intramural arterial cells via nitric oxide and endothelin-1.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomechanics and Modeling in Mechanobiology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s10237-024-01884-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0

Abstract

Constrained mixture models have successfully simulated many cases of growth and remodeling in soft biological tissues. So far, extensions of these models have been proposed to include either intracellular signaling or chemo-mechanical coupling on the organ-scale. However, no version of constrained mixture models currently exists that includes both aspects. Here, we propose such a version that resolves cellular signal processing by a set of logic-gated ordinary differential equations and captures chemo-mechanical interactions between cells by coupling a reaction-diffusion equation with the equations of nonlinear continuum mechanics. To demonstrate the potential of the model, we present 2 case studies within vascular solid mechanics: (i) the influence of angiotensin II on aortic growth and remodeling and (ii) the effect of communication between endothelial and intramural arterial cells via nitric oxide and endothelin-1.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
软组织生长和重塑的生物化学力学多尺度均质约束混合物模型。
受限混合模型已成功模拟了许多软生物组织的生长和重塑情况。迄今为止,已有人提出对这些模型进行扩展,以包括器官尺度上的细胞内信号传递或化学-机械耦合。然而,目前还没有同时包含这两个方面的约束混合物模型版本。在这里,我们提出了这样一个版本,它通过一组逻辑门控常微分方程来解决细胞信号处理问题,并通过将反应扩散方程与非线性连续介质力学方程耦合来捕捉细胞间的化学机械相互作用。为了证明该模型的潜力,我们介绍了血管固体力学中的两个案例研究:(i) 血管紧张素 II 对主动脉生长和重塑的影响;(ii) 内皮细胞和动脉内膜细胞之间通过一氧化氮和内皮素-1 进行交流的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology 工程技术-工程:生物医学
CiteScore
7.10
自引率
8.60%
发文量
119
审稿时长
6 months
期刊介绍: Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.
期刊最新文献
Investigating wall shear stress and the static pressure in bone scaffolds: a study of porosity and fluid flow dynamics. A multiphasic model for determination of mouse ascending thoracic aorta mass transport properties with and without aneurysm. Piezoelectricity and flexoelectricity in biological cells: the role of cell structure and organelles. Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling. Three-dimensional anisotropic unified continuum model for simulating the healing of damaged soft biological tissues.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1