Lyandra Dias da Silva, Nilmara Cunha da Silva, Bianca Mickaela Santos Chaves, Loanne Rocha Santos, Thayanne Gabryelle Visgueira de Sousa, Emyle Horrana Serafim de Oliveira, Tamires da Cunha Soares, Stéfany Rodrigues de Sousa Melo, Gilberto Simeone Henriques, Francisco Erasmo de Oliveira, Juliana Soares Severo, Jorddam Almondes Martins, Esmeralda Maria Lustosa Barros, Mayara Storel Beserra de Moura, Dilina do Nascimento Marreiro
{"title":"Copper biomarkers and their relationship with dyslipidemia in women with obesity.","authors":"Lyandra Dias da Silva, Nilmara Cunha da Silva, Bianca Mickaela Santos Chaves, Loanne Rocha Santos, Thayanne Gabryelle Visgueira de Sousa, Emyle Horrana Serafim de Oliveira, Tamires da Cunha Soares, Stéfany Rodrigues de Sousa Melo, Gilberto Simeone Henriques, Francisco Erasmo de Oliveira, Juliana Soares Severo, Jorddam Almondes Martins, Esmeralda Maria Lustosa Barros, Mayara Storel Beserra de Moura, Dilina do Nascimento Marreiro","doi":"10.1007/s10534-024-00641-x","DOIUrl":null,"url":null,"abstract":"<p><p>Adipose tissue dysfunction influences the development of dyslipidemias associated with obesity, however, the mechanisms are still unclear. In this sense, the literature highlights the role of copper in cholesterol synthesis, contributing to the increase in concentrations of this lipid fraction and consequently to the manifestation of dyslipidemia. The objective of the study was to investigate the relationship between copper parameters and lipid profile markers in women with obesity. This is a cross-sectional study involving women aged 20 to 50 years divided into a case group (BMI ≥ 35 kg/m<sup>2</sup>) and a control group (BMI between 18.5 and 24.9 kg/m<sup>2</sup>). Copper concentrations in plasma and erythrocytes were determined by inductively coupled plasma optical emission spectrophotometry and ceruloplasmin activity by spectrophotometry. The lipid fractions were analyzed according to the enzymatic colorimetric method, using an automatic biochemical analyzer. Participants with obesity had elevated concentrations of copper in plasma and reduced concentrations in erythrocytes compared to the control group, but there was no significant difference in ceruloplasmin activity between the groups. The research does not identify a correlation between copper parameters and serum concentrations of lipid fractions, which does not allow inferring the role of copper in the manifestation of dyslipidemia in obesity.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biometals","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s10534-024-00641-x","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Adipose tissue dysfunction influences the development of dyslipidemias associated with obesity, however, the mechanisms are still unclear. In this sense, the literature highlights the role of copper in cholesterol synthesis, contributing to the increase in concentrations of this lipid fraction and consequently to the manifestation of dyslipidemia. The objective of the study was to investigate the relationship between copper parameters and lipid profile markers in women with obesity. This is a cross-sectional study involving women aged 20 to 50 years divided into a case group (BMI ≥ 35 kg/m2) and a control group (BMI between 18.5 and 24.9 kg/m2). Copper concentrations in plasma and erythrocytes were determined by inductively coupled plasma optical emission spectrophotometry and ceruloplasmin activity by spectrophotometry. The lipid fractions were analyzed according to the enzymatic colorimetric method, using an automatic biochemical analyzer. Participants with obesity had elevated concentrations of copper in plasma and reduced concentrations in erythrocytes compared to the control group, but there was no significant difference in ceruloplasmin activity between the groups. The research does not identify a correlation between copper parameters and serum concentrations of lipid fractions, which does not allow inferring the role of copper in the manifestation of dyslipidemia in obesity.
期刊介绍:
BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of:
- metal ions
- metal chelates,
- siderophores,
- metal-containing proteins
- biominerals in all biosystems.
- BioMetals rapidly publishes original articles and reviews.
BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.