Copper biomarkers and their relationship with dyslipidemia in women with obesity.

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-10-16 DOI:10.1007/s10534-024-00641-x
Lyandra Dias da Silva, Nilmara Cunha da Silva, Bianca Mickaela Santos Chaves, Loanne Rocha Santos, Thayanne Gabryelle Visgueira de Sousa, Emyle Horrana Serafim de Oliveira, Tamires da Cunha Soares, Stéfany Rodrigues de Sousa Melo, Gilberto Simeone Henriques, Francisco Erasmo de Oliveira, Juliana Soares Severo, Jorddam Almondes Martins, Esmeralda Maria Lustosa Barros, Mayara Storel Beserra de Moura, Dilina do Nascimento Marreiro
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Abstract

Adipose tissue dysfunction influences the development of dyslipidemias associated with obesity, however, the mechanisms are still unclear. In this sense, the literature highlights the role of copper in cholesterol synthesis, contributing to the increase in concentrations of this lipid fraction and consequently to the manifestation of dyslipidemia. The objective of the study was to investigate the relationship between copper parameters and lipid profile markers in women with obesity. This is a cross-sectional study involving women aged 20 to 50 years divided into a case group (BMI ≥ 35 kg/m2) and a control group (BMI between 18.5 and 24.9 kg/m2). Copper concentrations in plasma and erythrocytes were determined by inductively coupled plasma optical emission spectrophotometry and ceruloplasmin activity by spectrophotometry. The lipid fractions were analyzed according to the enzymatic colorimetric method, using an automatic biochemical analyzer. Participants with obesity had elevated concentrations of copper in plasma and reduced concentrations in erythrocytes compared to the control group, but there was no significant difference in ceruloplasmin activity between the groups. The research does not identify a correlation between copper parameters and serum concentrations of lipid fractions, which does not allow inferring the role of copper in the manifestation of dyslipidemia in obesity.

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肥胖妇女体内的铜生物标志物及其与血脂异常的关系。
脂肪组织功能障碍会影响与肥胖有关的血脂异常的发生,但其机制仍不清楚。从这个意义上讲,文献强调了铜在胆固醇合成中的作用,它有助于增加这种脂质部分的浓度,从而导致血脂异常的表现。本研究的目的是调查肥胖女性体内铜参数与血脂指标之间的关系。这是一项横断面研究,涉及 20 至 50 岁的女性,分为病例组(体重指数≥ 35 kg/m2)和对照组(体重指数介于 18.5 至 24.9 kg/m2)。采用电感耦合等离子体光发射分光光度法测定血浆和红细胞中的铜浓度,采用分光光度法测定脑磷脂酶活性。脂质组分则使用自动生化分析仪,按照酶比色法进行分析。与对照组相比,肥胖症参与者血浆中的铜浓度升高,红细胞中的铜浓度降低,但两组之间的脑磷脂酶活性没有显著差异。这项研究没有发现铜参数与血清中脂质组分浓度之间的相关性,因此无法推断铜在肥胖症患者血脂异常表现中的作用。
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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
期刊最新文献
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