Pathogenesis and therapeutic strategies for cancer-related depression.

IF 3.6 3区 医学 Q2 ONCOLOGY American journal of cancer research Pub Date : 2024-09-15 eCollection Date: 2024-01-01 DOI:10.62347/WVVG5364
Meishan Liu, Ran Yan, Shaoteng Lu, Ping Zhang, Sheng Xu
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Abstract

Depression is a common co-morbidity among cancer cases, which has a detrimental influence on cancer treatment and prognosis. Recent advancements in the neurobiology of depression and cancer pathophysiology have revealed several shared biobehavioral mechanisms and introduced new therapeutic strategies. In this review, we summarize the biological mechanisms driving cancer-related depression, including psychosocial factors, immuno-inflammatory processes, chronic stress, dysbiosis of gut microbiota, and medically-induced factors. Interventions used for cancer-related depression may include psychosocial therapies, pharmacological therapies, immunotherapies, psychobiological medications, and dietary strategies. This review could inspire the elucidation of possible co-occurring mechanisms and complex interactions between cancer and depression, provide an opportunity to propose faster and more effective therapies for cancer-related depression, and well as new strategies for cancer in the future.

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癌症相关抑郁症的发病机制和治疗策略。
抑郁症是癌症病例中常见的并发症,对癌症治疗和预后有不利影响。抑郁症神经生物学和癌症病理生理学的最新进展揭示了一些共同的生物行为机制,并引入了新的治疗策略。在这篇综述中,我们总结了导致癌症相关抑郁症的生物机制,包括社会心理因素、免疫炎症过程、慢性应激、肠道微生物群失调以及药物诱导因素。用于治疗癌症相关抑郁症的干预措施包括社会心理疗法、药物疗法、免疫疗法、心理生物药物和饮食策略。本综述有助于阐明癌症与抑郁症之间可能存在的共存机制和复杂的相互作用,为提出更快、更有效的癌症相关抑郁症疗法以及未来的癌症治疗新策略提供机会。
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来源期刊
自引率
3.80%
发文量
263
期刊介绍: The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.
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