Nabeel Khan, Dhruvan Patel, Ramaswamy Sundararajan
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引用次数: 0
Abstract
Introduction: There is paucity of data on the incidence of severe thiopurine (TP)-induced myelosuppression (TIM) among inflammatory bowel disease (IBD) patients.
Methods: Utilizing the Veterans Affairs Healthcare system we identified IBD patients with normal pre-treatment thiopurine S-methyltransferase(TPMT) levels who received TPs for 6 months and developed severe TIM.
Results: Among 73,392 IBD patients, 14,760 had received TPs, and 2823 had a normal TPMT level. The incidence rate of severe TIM was 1.25 per 1000 patient-years.
Discussion: The incidence of severe TIM was very low, calling into question the necessity of frequent long-term CBC monitoring among IBD patients on TPs.
期刊介绍：
Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.
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