首页 > 最新文献

American Journal of Gastroenterology最新文献

英文 中文
The Minimally Invasive 1-Hr Esophageal String Test (EST) Monitors Therapeutic Changes in Mucosal Inflammation in Eosinophilic Esophagitis. 微创 1 小时食管弦试验 (EST) 可监测嗜酸性粒细胞食管炎患者黏膜炎症的治疗变化。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.14309/ajg.0000000000003192
Steven J Ackerman, Amir F Kagalwalla, Zhaoxing Pan, Joshua Wechsler, Kaitlin Keeley, Nirmala Gonsalves, Ikuo Hirano, Angelika Zalewski, Paul Menard-Katcher, Calies Menard-Katcher, Sandeep K Gupta, Nikhil Chauhan, Milica Grozdanovic, Dan Atkins, Nathalie Nguyen, Glenn T Furuta

Background: Endoscopy, standard-of-care for monitoring Eosinophilic Esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST®), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment.

Methods: Thirty-three samples from 14 EoE patients (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs analyzed for EoEScores.

Results: Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.

Conclusion: The EST can be used to longitudinally monitor responses to treatment in EoE.

背景:内窥镜检查是监测嗜酸性粒细胞食管炎(EoE)的标准方法,可评估粘膜炎症。食管弦试验(EST®)是一种微创吞咽胶囊和免疫测定,可量化嗜酸性粒细胞食管炎的炎症。我们确定EST/EoEScore能否监测正在接受治疗的患者的病情:研究了来自 14 名咽喉炎患者(7 名儿童,7 名成人)的 33 份样本,这些患者接受了重复内窥镜检查和EST。对活检样本进行嗜酸性粒细胞峰值计数分析;对EST进行嗜酸性粒细胞评分分析:结果:在治疗过程中,嗜酸性粒细胞计数和嗜酸性粒细胞分布指数有明显的相关性,93.9%的EST可将活动性咽喉炎患者与治疗相关缓解患者区分开来:EST可用于纵向监测咽喉炎患者的治疗反应。
{"title":"The Minimally Invasive 1-Hr Esophageal String Test (EST) Monitors Therapeutic Changes in Mucosal Inflammation in Eosinophilic Esophagitis.","authors":"Steven J Ackerman, Amir F Kagalwalla, Zhaoxing Pan, Joshua Wechsler, Kaitlin Keeley, Nirmala Gonsalves, Ikuo Hirano, Angelika Zalewski, Paul Menard-Katcher, Calies Menard-Katcher, Sandeep K Gupta, Nikhil Chauhan, Milica Grozdanovic, Dan Atkins, Nathalie Nguyen, Glenn T Furuta","doi":"10.14309/ajg.0000000000003192","DOIUrl":"10.14309/ajg.0000000000003192","url":null,"abstract":"<p><strong>Background: </strong>Endoscopy, standard-of-care for monitoring Eosinophilic Esophagitis (EoE), assesses mucosal inflammation. The Esophageal String Test (EST®), a minimally invasive swallowed capsule and immunoassays, quantifies EoE inflammation. We determined whether the EST/EoEScore can monitor disease in patients undergoing treatment.</p><p><strong>Methods: </strong>Thirty-three samples from 14 EoE patients (7 children, 7 adults) who underwent repeat endoscopies and ESTs were studied. Biopsies were analyzed for peak eosinophil counts; ESTs analyzed for EoEScores.</p><p><strong>Results: </strong>Eosinophil counts and EoEScores significantly correlated during treatment, distinguishing patients with active EoE from treatment-associated remissions for 93.9% of ESTs performed.</p><p><strong>Conclusion: </strong>The EST can be used to longitudinally monitor responses to treatment in EoE.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perforation of sigmoid colon by trans-anal decompression tube successfully treated using Over-The-Scope Clip system. 使用 Over-The-Scope Clip 系统成功治疗了经肛门减压管造成的乙状结肠穿孔。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-06 DOI: 10.14309/ajg.0000000000003193
Hideaki Kazumori, Kousuke Fukuda
{"title":"Perforation of sigmoid colon by trans-anal decompression tube successfully treated using Over-The-Scope Clip system.","authors":"Hideaki Kazumori, Kousuke Fukuda","doi":"10.14309/ajg.0000000000003193","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003193","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Prakash and Sethi. 回复 Prakash 和 Sethi。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-05 DOI: 10.14309/ajg.0000000000003130
Emma Vanderschueren, Wim Laleman
{"title":"Reply to Prakash and Sethi.","authors":"Emma Vanderschueren, Wim Laleman","doi":"10.14309/ajg.0000000000003130","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003130","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing the ACG Leadership Pipeline: Impact of the ACG Institute Leadership Programs 2018-2023. 开发 ACG 领导力管道:2018-2023 年 ACG 学院领导力课程的影响。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-05 DOI: 10.14309/ajg.0000000000003173
Neena S Abraham, Meridith Phillips
{"title":"Developing the ACG Leadership Pipeline: Impact of the ACG Institute Leadership Programs 2018-2023.","authors":"Neena S Abraham, Meridith Phillips","doi":"10.14309/ajg.0000000000003173","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003173","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guidelines in Practice: Management of Acute Pancreatitis. 实践指南:急性胰腺炎的治疗。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-05 DOI: 10.14309/ajg.0000000000003180
Daniel Marino, Jasmine Saini, Scott Tenner
{"title":"Guidelines in Practice: Management of Acute Pancreatitis.","authors":"Daniel Marino, Jasmine Saini, Scott Tenner","doi":"10.14309/ajg.0000000000003180","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003180","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duodenal Obstruction Caused by an Isolated Spontaneous Celiac Artery Dissection. 孤立的自发性腹腔动脉离断引起的十二指肠梗阻
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-04 DOI: 10.14309/ajg.0000000000003134
Avi Toiv, Zachary Saleh, Andrew M Watson, Cyrus R Piraka
{"title":"Duodenal Obstruction Caused by an Isolated Spontaneous Celiac Artery Dissection.","authors":"Avi Toiv, Zachary Saleh, Andrew M Watson, Cyrus R Piraka","doi":"10.14309/ajg.0000000000003134","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003134","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Gel Immersion Endoscopy to Control Duodenum Spasm During Endoscopic Retrograde Cholangiopancreatography. 在内镜逆行胰胆管造影术中使用凝胶浸泡内镜控制十二指肠痉挛。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-03-13 DOI: 10.14309/ajg.0000000000002752
Yuki Ishikawa-Kakiya, Hirotsugu Maruyama, Kojiro Tanoue, Akira Higashimori, Shusei Fukunaga, Yasuhiro Fujiwara
{"title":"Using Gel Immersion Endoscopy to Control Duodenum Spasm During Endoscopic Retrograde Cholangiopancreatography.","authors":"Yuki Ishikawa-Kakiya, Hirotsugu Maruyama, Kojiro Tanoue, Akira Higashimori, Shusei Fukunaga, Yasuhiro Fujiwara","doi":"10.14309/ajg.0000000000002752","DOIUrl":"10.14309/ajg.0000000000002752","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140108826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Risks of Cirrhosis and Hepatocellular Carcinoma Across Steatotic Liver Disease Subtypes. 不同脂肪肝亚型发生肝硬化和肝细胞癌的长期风险。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-03-07 DOI: 10.14309/ajg.0000000000002778
Yi-Ting Chen, Tzu-I Chen, Tsai-Hsuan Yang, Szu-Ching Yin, Sheng-Nan Lu, Xia-Rong Liu, Yun-Zheng Gao, Chih-Jo Lin, Chia-Wei Huang, Jee-Fu Huang, Ming-Lun Yeh, Chung-Feng Huang, Chia-Yen Dai, Wan-Long Chuang, Hwai-I Yang, Ming-Lung Yu, Mei-Hsuan Lee

Introduction: The prospective study aimed to investigate the long-term associated risks of cirrhosis and hepatocellular carcinoma (HCC) across various subtypes of steatotic liver disease (SLD).

Methods: We enrolled 332,175 adults who participated in a health screening program between 1997 and 2013. Participants were categorized into various subtypes, including metabolic dysfunction-associated SLD (MASLD), MASLD with excessive alcohol consumption (MetALD), and alcohol-related liver disease (ALD), based on ultrasonography findings, alcohol consumption patterns, and cardiometabolic risk factors. We used computerized data linkage with nationwide registries from 1997 to 2019 to ascertain the incidence of cirrhosis and HCC.

Results: After a median follow-up of 16 years, 4,458 cases of cirrhosis and 1,392 cases of HCC occurred in the entire cohort, resulting in an incidence rate of 86.1 and 26.8 per 100,000 person-years, respectively. The ALD group exhibited the highest incidence rate for cirrhosis and HCC, followed by MetALD, MASLD, and non-SLD groups. The multivariate adjusted hazard ratios for HCC were 1.92 (95% confidence interval [CI] 1.51-2.44), 2.91 (95% CI 2.11-4.03), and 2.59 (95% CI 1.93-3.48) for MASLD, MetALD, and ALD, respectively, when compared with non-SLD without cardiometabolic risk factors. The pattern of the associated risk of cirrhosis was similar to that of HCC (all P value <0.001). The associated risk of cirrhosis for ALD increased to 4.74 (95% CI 4.08-5.52) when using non-SLD without cardiometabolic risk factors as a reference.

Discussion: This study highlights elevated risks of cirrhosis and HCC across various subtypes of SLD compared with non-SLD, emphasizing the importance of behavioral modifications for early prevention.

简介:这项前瞻性研究旨在调查不同亚型脂肪性肝病(SLD)的肝硬化和肝细胞癌(HCC)的长期相关风险:这项前瞻性研究旨在调查不同亚型脂肪性肝病(SLD)的肝硬化和肝细胞癌(HCC)的长期相关风险:我们招募了 332,175 名成年人,他们在 1997 年至 2013 年间参加了一项健康筛查计划。根据超声波检查结果、饮酒模式和心脏代谢风险因素,我们将参与者分为不同的亚型,包括代谢功能障碍相关性脂肪性肝病(MASLD)、代谢功能障碍伴过量饮酒肝病(MetALD)和酒精相关性肝病(ALD)。我们利用计算机与1997年至2019年的全国性登记数据进行连接,以确定肝硬化和HCC的发病率:中位随访 16 年后,整个队列中有 4,458 例肝硬化和 1,392 例 HCC,发病率分别为每 10 万人年 86.1 例和 26.8 例。ALD组的肝硬化和HCC发病率最高,其次是MetALD组、MASLD组和非SLD组。与无心脏代谢风险因素的非SLD相比,MASLD、MetALD和ALD的HCC多变量调整危险比分别为1.92(95% CI:1.51-2.44)、2.91(95% CI:2.11-4.03)和2.59(95% CI:1.93-3.48)。肝硬化相关风险的模式与 HCC 相似(所有 p 值):本研究强调了与非 SLD 相比,不同亚型的 SLD 罹患肝硬化和 HCC 的风险均有所升高,从而强调了行为调整对于早期预防的重要性。
{"title":"Long-term Risks of Cirrhosis and Hepatocellular Carcinoma Across Steatotic Liver Disease Subtypes.","authors":"Yi-Ting Chen, Tzu-I Chen, Tsai-Hsuan Yang, Szu-Ching Yin, Sheng-Nan Lu, Xia-Rong Liu, Yun-Zheng Gao, Chih-Jo Lin, Chia-Wei Huang, Jee-Fu Huang, Ming-Lun Yeh, Chung-Feng Huang, Chia-Yen Dai, Wan-Long Chuang, Hwai-I Yang, Ming-Lung Yu, Mei-Hsuan Lee","doi":"10.14309/ajg.0000000000002778","DOIUrl":"10.14309/ajg.0000000000002778","url":null,"abstract":"<p><strong>Introduction: </strong>The prospective study aimed to investigate the long-term associated risks of cirrhosis and hepatocellular carcinoma (HCC) across various subtypes of steatotic liver disease (SLD).</p><p><strong>Methods: </strong>We enrolled 332,175 adults who participated in a health screening program between 1997 and 2013. Participants were categorized into various subtypes, including metabolic dysfunction-associated SLD (MASLD), MASLD with excessive alcohol consumption (MetALD), and alcohol-related liver disease (ALD), based on ultrasonography findings, alcohol consumption patterns, and cardiometabolic risk factors. We used computerized data linkage with nationwide registries from 1997 to 2019 to ascertain the incidence of cirrhosis and HCC.</p><p><strong>Results: </strong>After a median follow-up of 16 years, 4,458 cases of cirrhosis and 1,392 cases of HCC occurred in the entire cohort, resulting in an incidence rate of 86.1 and 26.8 per 100,000 person-years, respectively. The ALD group exhibited the highest incidence rate for cirrhosis and HCC, followed by MetALD, MASLD, and non-SLD groups. The multivariate adjusted hazard ratios for HCC were 1.92 (95% confidence interval [CI] 1.51-2.44), 2.91 (95% CI 2.11-4.03), and 2.59 (95% CI 1.93-3.48) for MASLD, MetALD, and ALD, respectively, when compared with non-SLD without cardiometabolic risk factors. The pattern of the associated risk of cirrhosis was similar to that of HCC (all P value <0.001). The associated risk of cirrhosis for ALD increased to 4.74 (95% CI 4.08-5.52) when using non-SLD without cardiometabolic risk factors as a reference.</p><p><strong>Discussion: </strong>This study highlights elevated risks of cirrhosis and HCC across various subtypes of SLD compared with non-SLD, emphasizing the importance of behavioral modifications for early prevention.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Insights Into Ultra-processed Food Consumption and Gastrointestinal Cancer Risk. 进一步了解超加工食品的消费与胃肠道癌症风险。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-07-16 DOI: 10.14309/ajg.0000000000002923
Lu Hao, Jisu Xue
{"title":"Improving Insights Into Ultra-processed Food Consumption and Gastrointestinal Cancer Risk.","authors":"Lu Hao, Jisu Xue","doi":"10.14309/ajg.0000000000002923","DOIUrl":"10.14309/ajg.0000000000002923","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Retrograde Colonic Enema-Based Fecal Microbiota Transplantation in the Treatment of Childhood Constipation: A Randomized, Double-Blind, Controlled Trial. 逆行结肠灌肠粪便微生物群移植治疗儿童便秘的效果:随机双盲对照试验》。
IF 8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI: 10.14309/ajg.0000000000002958
Xu Gu, Zhonghua Yang, Youwei Kou, Fan Yang, Yang Wang, Ying Chen, Enhui Wang, Xuzheng Jiang, Yuzuo Bai, Zhibo Zhang, Shucheng Zhang

Introduction: Management of intractable childhood constipation is still challenging. The efficacy of retrograde colonic enema (RCE) with fecal microbiota transplantation (FMT) in intractable childhood constipation has not been established, although both have demonstrated potential in gastrointestinal diseases. The aim of this study was to determine the safety and efficacy of RCE-based FMT in the treatment of intractable constipation in children.

Methods: A randomized, double-blind, controlled trial with 110 children was conducted. The patients were randomly assigned to the FMT with RCE group or the placebo with RCE group. All participants received a daily RCE, followed by a 4-week FMT treatment (twice a week) and a 12-week follow-up period. Spontaneous bowel movements ≥ 3 per week were the main outcomes, and the risk ratio with 95% confidence interval (CI) was calculated. Changes in intestinal bacterial profile were analyzed by BOX-PCR-based DNA fingerprinting and sequencing. The adverse effects were assessed based on symptoms.

Results: At the end of the follow-up period, 22 patients (40.0%) in the FMT with RCE group and 10 patients (18.2%) in the placebo with RCE group had ≥ 3 spontaneous bowel movements per week (net difference = 21.8%, 95% CI: 13.2%-30.4%; risk ratio: 1.364, 95% CI: 1.063-1.749; P < 0.05). Both RCE and FMT enriched the intestinal bacterial diversity of patients with constipation. The adverse events were all mild self-limiting gastrointestinal symptoms.

Discussion: FMT enhances the efficacy of RCE, and the use of RCE-based FMT is a safe and effective method in the treatment of intractable constipation in children.

目的:顽固性儿童便秘的治疗仍然具有挑战性。逆行结肠灌肠(RCE)和粪便微生物群移植(FMT)对顽固性儿童便秘的疗效尚未确定,尽管这两种方法在胃肠道疾病中都具有潜力。本研究旨在确定基于 RCE 的粪便微生物群移植治疗儿童顽固性便秘的安全性和有效性:方法:对 110 名儿童进行了随机、双盲、对照试验。受试者被随机分配到带有 RCE 的 FMT 组或带有 RCE 的安慰剂组。所有受试者每天接受一次 RCE,然后接受为期 4 周的 FMT 治疗(每周两次)和为期 12 周的随访。每周自然排便次数≥3次是主要结果,并计算了风险比(RR)和95% CI。通过基于 BOX-PCR 的 DNA 指纹和测序分析了肠道细菌谱的变化。根据症状评估不良反应:结果:在随访期结束时,FMT 联合 RCE 组有 22 名患者(40.0%)和安慰剂联合 RCE 组有 10 名患者(18.2%)每周≥3 次 SBM(净差异 = 21.8%,95% CI:13.2%-30.4%;RR:1.364,95% CI:1.063-1.749;PConclusions:FMT增强了RCE的疗效,使用基于RCE的FMT治疗儿童顽固性便秘是一种安全有效的方法。
{"title":"Effects of Retrograde Colonic Enema-Based Fecal Microbiota Transplantation in the Treatment of Childhood Constipation: A Randomized, Double-Blind, Controlled Trial.","authors":"Xu Gu, Zhonghua Yang, Youwei Kou, Fan Yang, Yang Wang, Ying Chen, Enhui Wang, Xuzheng Jiang, Yuzuo Bai, Zhibo Zhang, Shucheng Zhang","doi":"10.14309/ajg.0000000000002958","DOIUrl":"10.14309/ajg.0000000000002958","url":null,"abstract":"<p><strong>Introduction: </strong>Management of intractable childhood constipation is still challenging. The efficacy of retrograde colonic enema (RCE) with fecal microbiota transplantation (FMT) in intractable childhood constipation has not been established, although both have demonstrated potential in gastrointestinal diseases. The aim of this study was to determine the safety and efficacy of RCE-based FMT in the treatment of intractable constipation in children.</p><p><strong>Methods: </strong>A randomized, double-blind, controlled trial with 110 children was conducted. The patients were randomly assigned to the FMT with RCE group or the placebo with RCE group. All participants received a daily RCE, followed by a 4-week FMT treatment (twice a week) and a 12-week follow-up period. Spontaneous bowel movements ≥ 3 per week were the main outcomes, and the risk ratio with 95% confidence interval (CI) was calculated. Changes in intestinal bacterial profile were analyzed by BOX-PCR-based DNA fingerprinting and sequencing. The adverse effects were assessed based on symptoms.</p><p><strong>Results: </strong>At the end of the follow-up period, 22 patients (40.0%) in the FMT with RCE group and 10 patients (18.2%) in the placebo with RCE group had ≥ 3 spontaneous bowel movements per week (net difference = 21.8%, 95% CI: 13.2%-30.4%; risk ratio: 1.364, 95% CI: 1.063-1.749; P < 0.05). Both RCE and FMT enriched the intestinal bacterial diversity of patients with constipation. The adverse events were all mild self-limiting gastrointestinal symptoms.</p><p><strong>Discussion: </strong>FMT enhances the efficacy of RCE, and the use of RCE-based FMT is a safe and effective method in the treatment of intractable constipation in children.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
American Journal of Gastroenterology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1