Effect of combined training in water on hippocampal neuronal Plasticity and memory function in healthy elderly rats.

IF 3.1 Q2 NEUROSCIENCES AIMS Neuroscience Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024017
Roya Askari, Mohadeseh NasrAbadi, Amir Hossein Haghighi, Mohammad Jahan Mahin, Rajabi Somayeh, Matteo Pusceddu
{"title":"Effect of combined training in water on hippocampal neuronal Plasticity and memory function in healthy elderly rats.","authors":"Roya Askari, Mohadeseh NasrAbadi, Amir Hossein Haghighi, Mohammad Jahan Mahin, Rajabi Somayeh, Matteo Pusceddu","doi":"10.3934/Neuroscience.2024017","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The cyclic AMP response element-binding protein (CREB) and nerve growth factor (NGF) have been proposed as key modulators of brain health and are involved in synaptic plasticity. The study investigates how combined water-based training affects hippocampal neuron plasticity and memory function in old rats.</p><p><strong>Methods: </strong>16 Wistar male rats 24-month-old were randomly divided into two groups: combined training (n = 8) and control (n = 8). Four sessions were performed per week for 10 weeks, and consisted of resistance and endurance training in water. The control group was placed in a water container during training for 30 minutes to be homogenized in terms of the stress conditions. The.NGF and CREB genes in the hippocampus were evaluated and the working memory was measured using real-time PCR and Y-maze tests. The SPSS 26 software was utilized in which independent t-tests were used to analyze the genes and the Mann-Whitney U test was used to analyze functional memory with a significant level of (P < 0.05).</p><p><strong>Results: </strong>The combined training resulted in a significant rise in NGF and CREB gene expression in the hippocampus tissue of elderly rats compared to the control group (P < 0.05); however, there was no notable difference in the Y maze performance test between the two groups (P < 0.05).</p><p><strong>Conclusions: </strong>These findings suggest that water-based combined training has beneficial effects on gene expression of NGF and CREB; however, it is necessary to conduct more studies to comprehend the effects of combined training on memory function.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486616/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIMS Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3934/Neuroscience.2024017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: The cyclic AMP response element-binding protein (CREB) and nerve growth factor (NGF) have been proposed as key modulators of brain health and are involved in synaptic plasticity. The study investigates how combined water-based training affects hippocampal neuron plasticity and memory function in old rats.

Methods: 16 Wistar male rats 24-month-old were randomly divided into two groups: combined training (n = 8) and control (n = 8). Four sessions were performed per week for 10 weeks, and consisted of resistance and endurance training in water. The control group was placed in a water container during training for 30 minutes to be homogenized in terms of the stress conditions. The.NGF and CREB genes in the hippocampus were evaluated and the working memory was measured using real-time PCR and Y-maze tests. The SPSS 26 software was utilized in which independent t-tests were used to analyze the genes and the Mann-Whitney U test was used to analyze functional memory with a significant level of (P < 0.05).

Results: The combined training resulted in a significant rise in NGF and CREB gene expression in the hippocampus tissue of elderly rats compared to the control group (P < 0.05); however, there was no notable difference in the Y maze performance test between the two groups (P < 0.05).

Conclusions: These findings suggest that water-based combined training has beneficial effects on gene expression of NGF and CREB; however, it is necessary to conduct more studies to comprehend the effects of combined training on memory function.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
水中综合训练对健康老年大鼠海马神经元可塑性和记忆功能的影响
目的:环磷酸腺苷反应元件结合蛋白(CREB)和神经生长因子(NGF)被认为是大脑健康的关键调节因子,并参与突触可塑性。本研究探讨了水基联合训练如何影响老年大鼠的海马神经元可塑性和记忆功能。方法:将 16 只 24 个月大的 Wistar 雄性大鼠随机分为两组:联合训练组(n = 8)和对照组(n = 8)。每周进行四次训练,为期 10 周,包括水中阻力和耐力训练。对照组在训练期间被放置在一个水容器中 30 分钟,以达到应激条件的均质化。对海马中的 NGF 和 CREB 基因进行了评估,并使用实时 PCR 和 Y 型迷宫测试对工作记忆进行了测量。使用 SPSS 26 软件,用独立 t 检验分析基因,用 Mann-Whitney U 检验分析功能记忆,显著水平为 (P < 0.05):结果:与对照组相比,联合训练使老年大鼠海马组织中的NGF和CREB基因表达量明显增加(P < 0.05);但两组大鼠在Y迷宫表现测试中没有明显差异(P < 0.05):这些研究结果表明,以水为基础的联合训练对 NGF 和 CREB 的基因表达有益处;但要了解联合训练对记忆功能的影响,还需要进行更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
期刊最新文献
Vagus nerve stimulation in dementia: A scoping review of clinical and pre-clinical studies. The potential of exosomal biomarkers: Revolutionizing Parkinson's disease: How do they influence pathogenesis, diagnosis, and therapeutic strategies? The effects of right temporoparietal junction stimulation on embodiment, presence, and performance in teleoperation. Cognitive effects of brief and intensive neurofeedback treatment in schizophrenia: a single center pilot study. Novel perspective of therapeutic modules to overcome motor and nonmotor symptoms in Parkinson's disease.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1