A dose-response meta-analysis of the relationship between number of pregnancies and risk of gynecological cancers.

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-10-13 DOI:10.1007/s00404-024-07774-x
Jalal Poorolajal, Amin Doosti-Irani, Ali Mohammad Karami, Marzieh Fattahi-Darghlou
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Abstract

Background: Despite several investigations, the association between the number of pregnancies and gynecological cancers remains inconclusive. To address this issue, we conducted a dose-response meta-analysis of observational studies.

Methods: We searched PubMed, Web of Science, and Scopus databases up to Jun 8, 2023, to identify observational studies that examined the association between the number of pregnancies and gynecologic cancers. To assess the heterogeneity across studies, we used the χ2 test and I2 statistics. We also explored the possibility of publication bias using Begg's and Egger's tests. The overall effect sizes were reported as odds ratios (ORs) with a 95% confidence interval (CI) using a random-effects model.

Results: Out of the 87,255 studies initially identified, a total of 101 studies involving 8,230,754 participants were included in the final meta-analysis. Our analysis revealed a positive trend between the number of pregnancies and cervical cancer; however, this association was not found to be statistically significant except for fifth pregnancy. Conversely, our findings showed a significant decreasing trend between the number of pregnancies and the risk of endometrial and ovarian cancers. There was insufficient evidence to establish a relationship between the number of pregnancies and the risk of vaginal, vulvar, and fallopian tube cancers.

Conclusions: Our study found a positive trend between the number of pregnancies and cervical cancer and a significant decreasing trend between the number of pregnancies and endometrial and ovarian cancers. These findings may have implications for counseling women about their reproductive health and the potential risks and benefits of pregnancy.

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关于怀孕次数与妇科癌症风险之间关系的剂量反应荟萃分析。
背景:尽管进行了多项调查,但怀孕次数与妇科癌症之间的关系仍无定论。为了解决这一问题,我们对观察性研究进行了剂量反应荟萃分析:我们检索了截至 2023 年 6 月 8 日的 PubMed、Web of Science 和 Scopus 数据库,以确定研究怀孕次数与妇科癌症之间关系的观察性研究。为了评估各研究之间的异质性,我们使用了χ2检验和I2统计量。我们还使用 Begg's 和 Egger's 检验探讨了发表偏倚的可能性。总体效应大小采用随机效应模型,以几率比(OR)和 95% 置信区间(CI)的形式进行报告:在最初确定的 87 255 项研究中,共有 101 项研究被纳入最终的荟萃分析,涉及 8 230 754 名参与者。我们的分析表明,怀孕次数与宫颈癌之间存在正相关趋势;但是,除第五次怀孕外,这种相关性在统计学上并不显著。相反,我们的研究结果表明,怀孕次数与子宫内膜癌和卵巢癌的风险呈显著下降趋势。没有足够的证据表明怀孕次数与患阴道癌、外阴癌和输卵管癌的风险之间存在关系:我们的研究发现,怀孕次数与宫颈癌之间呈正相关趋势,而怀孕次数与子宫内膜癌和卵巢癌之间呈显著下降趋势。这些发现可能会对向妇女提供生殖健康咨询以及怀孕的潜在风险和益处产生影响。
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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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