Epidemiology and clinical implications of atrial fibrillation among stroke patients in Ethiopia: a comprehensive systematic review and meta-analysis.

IF 2.2 3区 医学 Q3 CLINICAL NEUROLOGY BMC Neurology Pub Date : 2024-10-14 DOI:10.1186/s12883-024-03894-8
Mohammed Mecha, Yordanos Sisay, Tsegaye Melaku
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Abstract

Background: Atrial fibrillation (AF) is a significant risk factor for stroke, imposing a substantial burden on healthcare systems. While studies have shown varying AF prevalence among stroke patients, limited pooled data exists in low-resource settings like Ethiopia. This hinders our understanding of the problem's extent and limits effective prevention and management strategies. Therefore, this systematic review and meta-analysis aimed to determine the pooled prevalence of atrial fibrillation among stroke patients in Ethiopia.

Methods: The searches were carried out in electronic databases such as PubMed/MEDLINE, EMBASE, Science Direct, Web of Science, and Google Scholar. Observational study designs were selected, and studies published until 30 November 2023 addressing the prevalence of atrial fibrillation among stroke patients were identified. Endnote citation manager software version X9 for Windows was used to collect and organize the search outcomes and remove duplicate articles. The relevant data were extracted from the included studies using a format prepared in Microsoft Excel and exported to STATA 18.0 software for the outcome measures analyses and subgrouping.

Results: Twenty-three research articles were included in the final analysis. These studies evaluated a total of 4,544 stroke patients, of whom 529 were diagnosed with atrial fibrillation (AF). The overall pooled prevalence of AF among stroke patients was 13% [95% CI: (10%, 17%)]. Subgroup analysis by region revealed that the highest pooled prevalence of AF was 16% [95% CI: (8%, 25%)] in the Amhara region, followed by the Oromia region at 15% [95% CI: (7%, 23%)]. In Addis Ababa City, the pooled prevalence of AF among stroke patients was 11% [95% CI: (7%, 15%)]. The Tigray region reported a pooled prevalence of 9% [95% CI: (6%, 11%)]. However, one study from the Southern Nations, Nationalities, and Peoples' Region reported a lower prevalence of AF among stroke patients at 7% [95% CI: (3%, 11%)].

Conclusion: In summary, the study revealed that AF is prevalent among stroke patients in Ethiopia, with regional differences in prevalence. The high prevalence of AF emphasizes the necessity for effective management strategies to prevent recurrent strokes.

Systematic review registration number: PROSPERO CRD: CRD42024581661.

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埃塞俄比亚中风患者心房颤动的流行病学和临床影响:一项全面的系统综述和荟萃分析。
背景:心房颤动(房颤)是中风的重要危险因素,给医疗系统带来了沉重负担。虽然研究显示中风患者中心房颤动的发病率各不相同,但在埃塞俄比亚这样的低资源环境中,汇集的数据非常有限。这阻碍了我们对这一问题严重程度的了解,并限制了有效的预防和管理策略。因此,本系统综述和荟萃分析旨在确定埃塞俄比亚中风患者心房颤动的总体患病率:在 PubMed/MEDLINE、EMBASE、Science Direct、Web of Science 和 Google Scholar 等电子数据库中进行检索。选择了观察性研究设计,并确定了截至 2023 年 11 月 30 日发表的有关中风患者心房颤动患病率的研究。使用 Windows 版 Endnote 引文管理软件 X9 收集和整理检索结果,并删除重复文章。使用 Microsoft Excel 编制的格式从纳入的研究中提取相关数据,并导出到 STATA 18.0 软件中进行结果测量分析和分组:最终分析共纳入 23 篇研究文章。这些研究共评估了 4,544 名中风患者,其中 529 人被诊断为心房颤动(AF)。中风患者心房颤动的总患病率为 13% [95% CI:(10%,17%)]。按地区进行的分组分析显示,阿姆哈拉地区心房颤动的总患病率最高,为 16% [95% CI:(8%-25%)],其次是奥罗莫地区,为 15% [95% CI:(7%-23%)]。在亚的斯亚贝巴市,中风患者心房颤动的合并患病率为 11% [95% CI:(7%-15%)]。提格雷地区报告的合并患病率为 9% [95% CI:(6%,11%)]。然而,来自南方各族地区的一项研究报告称,中风患者中房颤的患病率较低,为 7% [95% CI:(3%, 11%)]:总之,研究显示房颤在埃塞俄比亚的中风患者中很普遍,但各地区的发病率存在差异。心房颤动的高发病率强调了采取有效管理策略预防中风复发的必要性:系统综述注册号:PROCERMO CRD:CRD42024581661。
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来源期刊
BMC Neurology
BMC Neurology 医学-临床神经学
CiteScore
4.20
自引率
0.00%
发文量
428
审稿时长
3-8 weeks
期刊介绍: BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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