BMC Neurology最新文献

Background: The thalamus plays a key role in motor and sensory processes of the brain. Though thalamic stroke is among the less frequent, even a minimal lesion can result in a serious impairment and long-lasting disability. After thalamic stroke, cases of dysexecutive syndrome and so-called diencephalic amnesia have been observed, yet the precise characterisation or categorisation of such amnestic syndrome is not available. Pure amnesia can be the one and only indication of a thalamic lesion. We present a unique case of a patient after left anterolateral thalamic stroke suffering from isolated severe amnesia and disorientation. We conducted extensive neuropsychological testing of the patient's memory and discovered contrasting results in different aspects of memory.

Case presentation: A 75-year-old woman was admitted for neurological rehabilitation two weeks after being diagnosed with acute left anterolateral thalamic ischemic stroke. The initial symptoms with which she presented in the emergency room were acute confusion, disorientation and memory impairment; apart from that, the patient did not have any other neurologic signs. As observed on the MRI, the lesion was restricted mostly to the left anterior nucleus without affecting the mammillothalamic tract. The neuropsychological testing revealed anterograde episodic memory loss with preserved visual recognition and auditive short term memory; inability to freely recall semantic information, spatial and time disorientation, apathy and significantly reduced intrinsic and phasic attention, and immediate and delayed prose recall deficiency.

Conclusion: The knowledge that memory impairment and disorientation can be the only symptoms of the stroke is a crucial piece of information, which is needed to be able to make a decision about proper treatment. Abstention from immediate intervention often leads to irreparable memory deficit for the rest of the patient's life. The results of neuropsychological testing show the essential role of AN in creating episodic memory, in the working memory network and indicate its role as a critical interface between short-term and long-term memory. A theory explaining such a profound impairment of working and anterograde episodic memory has not yet been formulated.

Background: The primary symptoms in the early stages of anti-NMDA receptor encephalitis are psychiatric manifestations, making it difficult to distinguish from psychiatric disorders. While anti-NMDA receptor encephalitis requires a completely different treatment approach, the specific psychiatric features of the condition remain poorly identified. Although previous studies have suggested that altered perceptions may be characteristic, few case reports focus on altered perceptions of time or time distortion, a phenomenon closely linked to NMDA receptor dysfunction as seen in individuals using NMDA receptor inhibitors like ketamine and phencyclidine. In this report, we describe two cases of anti-NMDA receptor encephalitis manifesting pronounced time distortion in its early stages, which may serve as diagnostic clues for the early diagnosis and treatment of this potentially lethal condition.

Case presentations: Two cases of Anti-NMDA receptor encephalitis, both marked by significant time distortion in the early stages and showing near-complete recovery with immunotherapy, are presented in detail. In both cases, time distortion was the predominant symptom among the psychiatric manifestations. Case 1: A middle-aged man experienced a pronounced perception of time moving 100 times slower in the early stages, accompanied by feelings of detachment and auditory abnormalities. This time distortion persisted for over a year, even after other symptoms had fully resolved. Case 2: A young woman reported that time seemed to move two to three times slower in the early stages. Although she did not initially mention time distortion, she confirmed it when specifically questioned.

Conclusions: Our report suggests that time distortion, particularly the perception of time moving slowly, can be a distinguishing feature in the early stages of anti-NMDA receptor encephalitis. This unique characteristic, especially when occurring independently of other symptoms, is rare as a primary and isolated symptom in other conditions, making it useful for differentiation from time distortion in other psychiatric disorders. Additionally, since some patients may not spontaneously report time distortion, actively assessing this symptom during early evaluation could help improve diagnostic accuracy.

Background: Craniocerebral self-inflicted gunshot wounds (SIGSW) are fatal in 90% of individuals, usually before reaching a hospital setting. We report a unique SIGSW survivor's residual neurologic deficits, imaging, neuropsychiatric findings, and improvement in psychosis.

Case presentation: The patient is a 32-year-old right-handed Caucasian male with a medical history of paranoid schizophrenia who attempted suicide by SIGSW. After transport to the Emergency Department (ED), an emergent craniotomy was required for wound debridement, hematoma evacuation, and craniofacial reconstruction. He transitioned to rehabilitation and continued to improve. We evaluated him seven years later when he returned to the ED for breakthrough seizure activity. Detailed neurologic, neurobehavioral, and psychiatric evaluations were accomplished, including the Frontal Assessment Battery (FAB). His deficits included distractibility, impaired digit span, poor confrontation and generative naming, effortful spontaneous speech, and transcortical motor aphasia with frequent semantic paraphasic errors. Language comprehension was intact, and he answered simple questions with short responses. Psychiatric interviews of the patient and his mother revealed resolution of auditory hallucinations and paranoid delusions following recovery from the SIGSW.

Discussion: Our testing revealed widespread deficits on the FAB. Neurobehavioral and language assessments suggested frontal lobe dysfunction, including transcortical motor aphasia. His psychiatric interview findings revealed similarity to findings report in the 1940s-50s after frontal leukotomy initially proposed by Egas Moniz.

Conclusion: Frontal lobe damage produced cognitive and neurobehavioral impairments and improved neuropsychiatric symptoms such as hallucinations and psychosis in a SIGSW survivor.

Background: Warfarin is the most commonly used oral anticoagulant drug in clinical practice due to its effective anticoagulant effect and low cost. Warfarin plays a crucial role in the anticoagulant treatment of patients with thrombotic diseases such as atrial fibrillation, heart valve replacement, and deep vein thrombosis. In general, low-dose warfarin can effectively achieve the optimal international normalized ratio (INR) for patients requiring anticoagulation therapy. In some cases, patients may require significantly higher doses of warfarin to achieve an INR in the desired range; failure to achieve this is commonly referred to as warfarin resistance. We report a rare case of cerebral infarction caused by atrial fibrillation and warfarin resistance in China.

Case presentation: A Chinese patient with atrial fibrillation complicated by cerebral infarction had been taking warfarin for 2 years, and the dose was gradually increased to 12.5 mg per day; however, the INR remained below the standard. The patient was considered to be resistant to warfarin. The cause of warfarin resistance in this patient is unknown, but we speculate that pharmacodynamic and genetic factors may be involved. Finally, we chose to replace warfarin with rivaroxaban to avoid the risk of bleeding at high doses. To date, there has been no bleeding or infarcts since the patient was discharged. In cases where the cause of warfarin resistance cannot be determined, alternative drugs may be more appropriate.

Conclusions: When considering warfarin resistance, it is important to actively search for the cause of resistance early on. If the cause is determined, appropriate measures should be taken. If the cause is not determined or cannot be resolved, the dose can be gradually increased under close monitoring, alternatives can be actively adopted, and patients can be informed and educated.

Background: The Circle of Willis (CoW) is a crucial cerebral arterial structure that facilitates collateral blood flow to the brain. Anatomical variations within the CoW are prevalent and can have significant clinical implications, particularly concerning strokes, aneurysms and other cerebrovascular disorders. This study aimed to assess the anatomical variations of the CoW in the Ethiopian population presenting with neurological symptoms and to explore the factors associated with these variations. By investigating these relationships, the research seeks to enhance understanding of the CoW's anatomical diversity and its potential impact on cerebrovascular health.

Methods: A facility-based cross-sectional study was conducted among adult patients undergone brain CT angiography at St. Paul's Hospital Millennium Medical College. A simple random sampling technique was employed to select participants. Multivariate binary logistic regression analyses were performed to determine relationships between dependent and independent variables. Statistical significance was assessed with a p-value < 0.05.

Results: This study of 86 participants (mean age 48.3 years) found that 56 (65.12%) had a complete CoW. Incomplete CoW was more common in females (OR = 3.5, p = 0.007) and was significantly associated with stroke (OR = 15.4, p < 0.001). Aneurysms had a higher but non-significant association with incomplete CoW (OR = 3.2, p = 0.14). Hypoplastic arteries were present in 30% of participants.

Conclusions: Hypoplastic arteries are more frequently observed in the posterior portion of the CoW than in the anterior portion. Most importantly, the incompleteness of the CoW is significantly associated with female sex and stroke.

Background and purpose: Ischemic stroke is a significant public health concern, particularly in Eastern Europe, where the burden remains high. This study aims to evaluate the trends and burden of ischemic stroke in Eastern Europe from 1990 to 2021, providing insights into epidemiological changes and informing public health strategies.

Methods: We used data from the Global Burden of Disease 2021 database to comprehensively assess regional and national ischemic stroke indicators in Eastern Europe. These indicators included the number of cases, incidence, number of deaths, mortality, disability-adjusted life years (DALYs), DALY rates, and estimated annual percentage change (EAPC). Joinpoint analysis was employed to examine sex-specific time trends in the burden of ischemic stroke across Eastern European countries. These estimates incorporated the Socio-Demographic Index (SDI).

Results: In 2021, Eastern Europe reported 490,197 cases of ischemic stroke, with an age-standardized incidence rate (ASIR) of 142.57 (95% UI: 122.12 to 164.67), exceeding the global level. The region recorded 329,291 deaths, with an age-standardized mortality rate (ASMR) of 90.99 (95% UI: 82.79 to 98.48), significantly higher than the global rate. Disability-adjusted life years (DALYs) totaled 5,713,718, with an age-standardized DALYs rate (ASDR) of 1601.20 (95% UI: 1483.51 to 1723.12). Our joinpoint regression analysis indicates that the disease burden remains notably high in Eastern Europe, despite an overall declining trend from 1990 to 2021 in ASIR and ASMR across most countries, with estimated annual percentage changes (EAPC) of -1.13 (95% CI: -1.24 to -1.02) and - 2.78 (95% CI: -3.24 to -2.32), respectively. Lithuania reported the highest incidence rate, while the Russian Federation had the highest mortality and DALY rate. Conversely, Estonia showed significant improvements in stroke indicators. Key risk factors included low temperature and smoking, contributing notably to environmental and behavioral risks.

Conclusion: Ischemic stroke continues to be a significant global health issue. Our temporal trends study results indicate that the disease burden remains notably high in Eastern Europe, particularly in Lithuania and the Russian Federation.

Background: Hydrocarbon exposure, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), is increasingly linked to vascular dysfunction and stroke, a leading cause of morbidity and mortality globally. Common in occupational and environmental contexts, hydrocarbons induce oxidative stress, systemic inflammation, and endothelial dysfunction, disrupting vascular health. This systematic review examines the association between hydrocarbon exposure and stroke, emphasizing specific metabolites and their cerebrovascular effects.

Methods: A comprehensive search across PubMed, Embase, and Web of Science was conducted through December 10 2024, identifying observational studies exploring hydrocarbon exposure and stroke risk. Studies meeting predefined inclusion criteria, excluding those with major methodological flaws, were synthesized narratively. Variations in hydrocarbon types, population demographics, and stroke outcomes were considered.

Results: Six studies, including five cross-sectional and one retrospective cohort, with sample sizes ranging from 5,537 to 283,666 participants, demonstrated significant associations between hydrocarbon exposure and stroke risk. Key findings revealed strong associations for metabolites like 1-hydroxynaphthalene (OR: 1.89; 95% CI: 1.62-2.20) and 2-hydroxyfluorene (OR: 1.94; 95% CI: 1.66-2.26). However, variability in findings was noted, attributed to differences in study design, exposure levels, and populations studied.

Conclusion: This review highlights a complex relationship between hydrocarbon exposure and stroke risk, with some studies indicating significant associations and others reporting inconsistencies. Standardized, large-scale research is essential to clarify this relationship, identify high-risk populations, and guide public health strategies to mitigate exposure and prevent stroke.

Clinical trial number: Not applicable.

Background: Guillain-Barré syndrome (GBS) is a group of immune-mediated peripheral neuropathies that causes acute flaccid paralysis. The global incidence of GBS was 0.6-4/100 000, and the incidence in China was 0.698/100 000. Although the diagnosis and treatment of GBS has made rapid progress, approximately 20% of patients with GBS are still unable to walk alone within 6 months after the onset of GBS, and 40% of patients have sequelae, such as weakened strength, limb pain, and numbness, seriously affecting their life and work. We aimed to retrospectively analyze the clinical characteristics of patients with GBS in Shenzhen, China and analyze the factors affecting disease severity to provide a reference for the precise treatment of GBS.

Methods: Clinical data of inpatients diagnosed with GBS in several hospitals in Shenzhen from April 2010 to October 2021 were obtained from an electronic medical record system (HIS system). The clinical characteristics of patients with GBS and the factors affecting disease severity were analyzed.

Results: A total of 146 patients were identified for this study, and 13 were lost during follow-up. During the follow-up period, three patients had acute-onset chronic inflammatory demyelinating polyneuropathy (A-CIDP). One hundred and thirty patients with complete data, comprising 90 males (69.23%) and 40 females (30.77%) with a median age of 39.50 ± 23.75 years, were included in the statistical analyses. Acute inflammatory demyelinating polyneuropathy (AIDP) was the most common electrophysiological variant (106 cases [81.54%]). Miller-Fisher syndrome (MFS), acute motor axonal neuropathy (AMAN), and acute motor-sensory axonal neuropathy (AMSAN) were noted in 21 (16.15%), 2 (1.54%), and 1 (0.77%) patients, respectively. The clinical course of the disease was mainly mild in 95 cases (73.08%), while 35 patients (26.92%) experienced severe disease. Logistic multivariate regression analysis showed that age ≥ 60 years old and having pneumonia may be associated with the severity of the disease.

Conclusions: AIDP is the most common electrophysiological variant of GBS in Shenzhen. Most cases of GBS in our setting are mild, and the long-term prognosis is favorable. Old age (≥ 60 years) and having pneumonia are independent risk factors for severe GBS.

Background: The lumbar sympathetic nerve block stands as a pivotal approach in managing complex regional pain syndrome (CRPS) in the lower limbs. Retroperitoneal hemorrhage is an extremely rare and severe complication of lumbar sympathetic nerve block. Here, we report for the first time a case of retroperitoneal hemorrhage that initially presented with symptoms of femoral nerve compression.

Case presentation: An 81-year-old elderly female was diagnosed with CRPS. After undergoing an ultrasound-guided lumbar sympathetic nerve block at our hospital, discomfort in her right lower back was experienced, followed by stabbing pain, numbness in the anterior thigh, and significant lower limb movement impairment. We considered that the femoral nerve might be compressed by a hematoma or abscess. An emergency percutaneous drainage was performed, resulting in partial symptom relief. However, two days later, signs of hemorrhagic shock were observed in the patient. An emergency lumbar arterial embolization was performed, effectively stabilizing her vital signs. One week later, lower limb pain and numbness disappeared, and right lower limb motor function fully recovered.

Conclusions: When retroperitoneal hemorrhage is suspected, prompt computed tomography (CT) or bedside ultrasound should be conducted. Once imaging supports the diagnosis, immediate digital subtraction angiography (DSA) could be utilized to identify the bleeding source and conduct embolization.

Objective: To evaluate the potential of two large language models (LLMs), GPT-4 (OpenAI) and PaLM2 (Google), in automating migraine literature analysis by conducting sentiment analysis of migraine medications in clinical trial abstracts.

Background: Migraine affects over one billion individuals worldwide, significantly impacting their quality of life. A vast amount of scientific literature on novel migraine therapeutics continues to emerge, but an efficient method by which to perform ongoing analysis and integration of this information poses a challenge.

Methods: "Sentiment analysis" is a data science technique used to ascertain whether a text has positive, negative, or neutral emotional tone. Migraine medication names were extracted from lists of licensed biological products from the FDA, and relevant abstracts were identified using the MeSH term "migraine disorders" on PubMed and filtered for clinical trials. Standardized prompts were provided to the APIs of both GPT-4 and PaLM2 to request an article sentiment as to the efficacy of each medication found in the abstract text. The resulting sentiment outputs were classified using both a binary and a distribution-based model to determine the efficacy of a given medication.

Results: In both the binary and distribution-based models, the most favorable migraine medications identified by GPT-4 and PaLM2 aligned with evidence-based guidelines for migraine treatment.

Conclusions: LLMs have potential as complementary tools in migraine literature analysis. Despite some inconsistencies in output and methodological limitations, the results highlight the utility of LLMs in enhancing the efficiency of literature review through sentiment analysis.