Recent radiotherapy could reduce heart-related death in patients with esophageal cancer: SEER database analysis.

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardio-oncology Pub Date : 2024-10-18 DOI:10.1186/s40959-024-00274-6

Yuta Sato, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Hinako Harada, Yasuhiro Seki, Nanae Chiba, Shinsaku Okuda, Keiichi Jingu

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Abstract

Background: There have been several reports showing that heart-related deaths are common in long-term survivors of esophageal cancer after radiation therapy; however, radiotherapy technology is evolving year by year. This study was carried out using the SEER database to determine whether the frequency of mortality from heart disease after radiotherapy has improved over time in patients with esophageal cancer.

Methods: SEER*Stat statistical software version 8.3.9.2 (National Cancer Institute) was used to perform case listing and data extraction. We reviewed causes of death in 8,297 patients who were treated by radiotherapy without surgery between 2004 and 2015 (radiotherapy group). For comparison with this group, we also reviewed causes of death in 5,149 patients who were treated by surgery without radiotherapy (surgery group).

Results: In the radiotherapy group, the cumulative heart-related death rate in patients with carcinoma in the middle to abdominal esophagus, for which it was considered that the heart was irradiated with a higher dose, was significantly higher than that in patients with carcinoma in the cervical to upper thoracic esophagus (p = 0.017). However, in the surgery group, the cumulative heart-related death rate in patients with carcinoma in the middle to abdominal esophagus tended to be lower than that in patients with carcinoma in the cervical to upper thoracic esophagus (p = 0.063). The cumulative heart-related death rate in patients treated in 2010-2015 was significantly lower than that in patients treated in 2004-2009 in the radiotherapy group (p = 0.011), although the cumulative heart-related death rate was not significantly different between patients treated in 2010-2015 and patients treated in 2004-2009 in the surgery group (p = 0.90).

Conclusions: The results suggest that recent advances in radiotherapy have enabled a reduction in radiation-induced heart disease in patients with esophageal cancer.

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近期放射治疗可减少食管癌患者因心脏原因死亡的人数：SEER 数据库分析。

背景：有多份报告显示，食管癌放疗后长期存活者中与心脏相关的死亡很常见；然而，放疗技术正在逐年发展。本研究利用 SEER 数据库来确定食道癌患者放疗后因心脏病死亡的频率是否随着时间的推移而有所改善：方法：使用 SEER*Stat 统计软件 8.3.9.2 版（美国国立癌症研究所）进行病例列表和数据提取。我们回顾了2004年至2015年间接受放疗而未接受手术治疗的8297名患者（放疗组）的死亡原因。为了与这组患者进行比较，我们还回顾了5149名接受手术治疗但未接受放疗的患者（手术组）的死亡原因：在放疗组中，中段至腹段食管癌患者的累积心脏相关死亡率明显高于颈段至上段胸段食管癌患者（P = 0.017），因为放疗对心脏的照射剂量更高。然而，在手术组中，食管中段至腹段癌患者的累积心脏相关死亡率往往低于食管颈段至胸段上段癌患者（p = 0.063）。在放疗组中，2010-2015年接受治疗的患者的累积心脏相关死亡率明显低于2004-2009年接受治疗的患者（p = 0.011），但在手术组中，2010-2015年接受治疗的患者与2004-2009年接受治疗的患者的累积心脏相关死亡率无明显差异（p = 0.90）：结果表明，放疗技术的最新进展减少了食管癌患者因放疗引发的心脏病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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