Recurrent melanoma 25 years after initial diagnosis, presenting as metastatic disease early after heart transplantation.

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardio-oncology Pub Date : 2024-10-16 DOI:10.1186/s40959-024-00273-7
Gal Rubinstein, Benjamin Izar, Diana E McDonnell, Andrea Fernandez Valledor, Justin A Fried, Kevin Clerkin, Edward F Lin, Dor Lotan, Farhana Latif, Gabriel Sayer, Nir Uriel, Jayant K Raikhelkar
{"title":"Recurrent melanoma 25 years after initial diagnosis, presenting as metastatic disease early after heart transplantation.","authors":"Gal Rubinstein, Benjamin Izar, Diana E McDonnell, Andrea Fernandez Valledor, Justin A Fried, Kevin Clerkin, Edward F Lin, Dor Lotan, Farhana Latif, Gabriel Sayer, Nir Uriel, Jayant K Raikhelkar","doi":"10.1186/s40959-024-00273-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cancer survivors (CS) comprise a particularly high-risk group for both de-novo and recurrent malignancies after solid organ transplantation.</p><p><strong>Case presentation: </strong>We report a case of relapsed melanoma, presented as metastatic disease seven months after heart transplantation in a patient who had an early-stage melanoma resected 25 years prior. Treatment with a combination of dabrafenib, a BRAF inhibitor, and trametinib, a mitogen-activated protein kinase (MEK) inhibitor resulted in a near-complete metabolic response, without major adverse effects.</p><p><strong>Conclusion: </strong>This case demonstrates the increased risk of recurrence in CS with melanoma, which can persist decades after cancer diagnosis. These patients may be amenable to treatment using modern treatment modalities in oncology.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481582/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardio-oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40959-024-00273-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Cancer survivors (CS) comprise a particularly high-risk group for both de-novo and recurrent malignancies after solid organ transplantation.

Case presentation: We report a case of relapsed melanoma, presented as metastatic disease seven months after heart transplantation in a patient who had an early-stage melanoma resected 25 years prior. Treatment with a combination of dabrafenib, a BRAF inhibitor, and trametinib, a mitogen-activated protein kinase (MEK) inhibitor resulted in a near-complete metabolic response, without major adverse effects.

Conclusion: This case demonstrates the increased risk of recurrence in CS with melanoma, which can persist decades after cancer diagnosis. These patients may be amenable to treatment using modern treatment modalities in oncology.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
初诊 25 年后复发的黑色素瘤,在心脏移植手术后早期出现转移性疾病。
背景:癌症幸存者(CS)是实体器官移植后发生新发和复发恶性肿瘤的高危人群:我们报告了一例黑色素瘤复发病例,患者在 25 年前曾切除过早期黑色素瘤,心脏移植后 7 个月出现转移性疾病。BRAF抑制剂达拉菲尼和丝裂原活化蛋白激酶(MEK)抑制剂曲美替尼联合治疗后,患者的代谢反应接近完全,且无重大不良反应:本病例表明,CS 黑色素瘤患者的复发风险增加,这可能在癌症确诊后持续数十年。这些患者可能适合采用现代肿瘤治疗方法进行治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Cardio-oncology
Cardio-oncology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.00
自引率
3.00%
发文量
17
审稿时长
7 weeks
期刊最新文献
Using machine learning in pediatric cardio-oncology: we have the questions, we need the answers. Accuracy of mitral annular plane systolic excursion in diagnosing anthracycline-induced subclinical cardiotoxicity in patients with breast cancer - a retrospective cohort study. Cardiotoxicity of venetoclax in patients with acute myeloid leukemia: comparison with anthracyclines. Unsupervised machine learning identifies distinct phenotypes in cardiac complications of pediatric patients treated with anthracyclines. Recent radiotherapy could reduce heart-related death in patients with esophageal cancer: SEER database analysis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1