Recurrent melanoma 25 years after initial diagnosis, presenting as metastatic disease early after heart transplantation.

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardio-oncology Pub Date : 2024-10-16 DOI:10.1186/s40959-024-00273-7
Gal Rubinstein, Benjamin Izar, Diana E McDonnell, Andrea Fernandez Valledor, Justin A Fried, Kevin Clerkin, Edward F Lin, Dor Lotan, Farhana Latif, Gabriel Sayer, Nir Uriel, Jayant K Raikhelkar
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Abstract

Background: Cancer survivors (CS) comprise a particularly high-risk group for both de-novo and recurrent malignancies after solid organ transplantation.

Case presentation: We report a case of relapsed melanoma, presented as metastatic disease seven months after heart transplantation in a patient who had an early-stage melanoma resected 25 years prior. Treatment with a combination of dabrafenib, a BRAF inhibitor, and trametinib, a mitogen-activated protein kinase (MEK) inhibitor resulted in a near-complete metabolic response, without major adverse effects.

Conclusion: This case demonstrates the increased risk of recurrence in CS with melanoma, which can persist decades after cancer diagnosis. These patients may be amenable to treatment using modern treatment modalities in oncology.

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初诊 25 年后复发的黑色素瘤,在心脏移植手术后早期出现转移性疾病。
背景:癌症幸存者(CS)是实体器官移植后发生新发和复发恶性肿瘤的高危人群:我们报告了一例黑色素瘤复发病例,患者在 25 年前曾切除过早期黑色素瘤,心脏移植后 7 个月出现转移性疾病。BRAF抑制剂达拉菲尼和丝裂原活化蛋白激酶(MEK)抑制剂曲美替尼联合治疗后,患者的代谢反应接近完全,且无重大不良反应:本病例表明,CS 黑色素瘤患者的复发风险增加,这可能在癌症确诊后持续数十年。这些患者可能适合采用现代肿瘤治疗方法进行治疗。
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来源期刊
Cardio-oncology
Cardio-oncology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.00
自引率
3.00%
发文量
17
审稿时长
7 weeks
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