BMI-1 in Breast Cancer - Biological Role and Clinical Implications.

IF 2.5 Q3 CELL BIOLOGY Cellular Physiology and Biochemistry Pub Date : 2024-10-15 DOI:10.33594/000000733
Aleksandra Szustka, Anna Krześlak
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Abstract

Breast cancer is the most frequent cancer among women. Despite extensive research in recent years the molecular basis of breast cancer development, growth and metastasis remains unclear. Numerous studies highlight the involvement of BMI-1 in tumorigenesis. BMI-1 protein is a key component of Polycomb Repressive Complex 1, which by ubiquitinylation of histone H2A, regulates expression of genes involved in various cellular processes including cell cycle, proliferation and programmed cell death. Overexpression of BMI-1 has been often associated with breast cancer development and progression. This review summarizes the current state of knowledge of BMI-1's role in breast cancer biology and its potential significance as prognostic marker and potential target of new anticancer therapy.

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乳腺癌中的 BMI-1 - 生物学作用和临床意义。
乳腺癌是女性最常见的癌症。尽管近年来进行了大量研究,但乳腺癌发生、生长和转移的分子基础仍不清楚。大量研究强调了 BMI-1 在肿瘤发生过程中的参与作用。BMI-1 蛋白是多聚核抑制复合体 1 的一个重要组成部分,它通过泛素化组蛋白 H2A,调节参与细胞周期、增殖和细胞程序性死亡等各种细胞过程的基因的表达。BMI-1 的过表达往往与乳腺癌的发生和发展有关。本综述总结了 BMI-1 在乳腺癌生物学中的作用及其作为预后标志物和新抗癌疗法潜在靶点的潜在意义。
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来源期刊
CiteScore
5.80
自引率
0.00%
发文量
86
审稿时长
1 months
期刊介绍: Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and biochemical disciplines as well as related fields such as genetics, molecular biology, pathophysiology, pathobiochemistry and cellular toxicology & pharmacology. Original papers and reviews on the mechanisms of intracellular transmission, cellular metabolism, cell growth, differentiation and death, ion channels and carriers, and the maintenance, regulation and disturbances of cell volume are presented. Appearing monthly under peer review, Cellular Physiology and Biochemistry takes an active role in the concerted international effort to unravel the mechanisms of cellular function.
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