Pilot scale polyhydroxyalkanoates biopolymer production using pure cultures: current status and future opportunities.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-10-20 DOI:10.1080/07388551.2024.2409112
Phavit Wongsirichot
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Abstract

The development and commercialization of bio-based and biodegradable polyhydroxyalkanoates (PHAs) biopolymers could be crucial for the transition toward a sustainable circular economy. However, despite potential traditional and novel applications in the packaging, textiles, agriculture, automotive, electronics, and biomedical industries, the commercialization of PHAs is limited by their current market competitiveness. This review provides the first critical assessment of the current pure culture pilot-scale PHA literature, which could be crucial in translating promising laboratory-scale developments into industrial-scale commercial PHA production. It will also complement reviews of mixed microbial cultures currently dominating pilot-scale PHA literature. Pure culture fermentations could provide advantages, such as ease of characterizing microbial producers' behavior, higher PHA productivities, and better alignment with existing PHA commercialization and industrial biotechnology approaches. Key aspects, including producer organisms, fermentation volumes and schemes, control schemes, optimization, and properties of the polymers produced, are discussed in-depth, to elucidate important trends, achievements, and knowledge gaps. Furthermore, specific ways for future pilot-scale studies to help address current PHA commercialization challenges are also identified. The insights, and recommendations provided will be extremely beneficial for the future development of PHA production, at both pilot and commercial scales, whilst also being beneficial to the production of other microbial polymers and industrial biotechnology as a whole.

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利用纯培养物生产中试规模的聚羟基烷酸酯生物聚合物:现状与未来机遇。
生物基可生物降解聚羟基烷酸酯(PHAs)生物聚合物的开发和商业化对于向可持续循环经济过渡至关重要。然而,尽管 PHAs 在包装、纺织、农业、汽车、电子和生物医学等行业具有潜在的传统和新型应用,但其商业化却受到当前市场竞争力的限制。本综述首次对目前纯培养中试规模的 PHA 文献进行了批判性评估,这对于将前景广阔的实验室规模开发转化为工业规模的商业 PHA 生产至关重要。它还将对目前在中试规模 PHA 文献中占主导地位的混合微生物培养的综述进行补充。纯培养发酵可提供一些优势,如易于表征微生物生产者的行为、更高的 PHA 生产率以及与现有 PHA 商业化和工业生物技术方法更好地结合。本文深入讨论了生产生物、发酵量和方案、控制方案、优化和所生产聚合物的特性等关键方面,以阐明重要趋势、成就和知识差距。此外,还确定了未来试点规模研究的具体方法,以帮助解决当前 PHA 商业化面临的挑战。所提供的见解和建议将对未来 PHA 生产在中试和商业规模上的发展大有裨益,同时也有利于其他微生物聚合物的生产和整个工业生物技术的发展。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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