Abnormal individualized functional connectivity: A potential stimulation target for pediatric tourette syndrome

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-10-09 DOI:10.1016/j.clinph.2024.09.026

Ye Wang , Juan Yue , Yu-Ting Lou , Qiu-Ye Lin , Yu-Feng Zang , Jue Wang , Jian-Hua Feng

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Abstract

Objective

In order to examine whether individualized peak functional connectivity could potentially serve as a target for repetitive transcranial magnetic stimulation (rTMS) therapy, we investigated the location of peak functional connectivity (FC) between the cortical motor area and the key brain region, the globus pallidus internus (GPi), in Tourette syndrome, and explored the relationship between the severity of the disease and these aberrant functional connections.

Methods

The study involved a cohort of 103 children diagnosed with Tourette syndrome and 66 age-matched typically developing children. The GPi was served as the seed, and the study compared individualized peak FC strength in the supplementary motor area (SMA) and premotor area between the two groups. Spatial distribution of peak FC in the motor area and GPi-based voxel-wise FC were also analyzed.

Results

Children with Tourette syndrome exhibited lower peak FC in the left SMA when using left GPi as the seed. This reduction in peak FC demonstrated a significant and negative correlation with the Yale Global Tic Severity Scale scores.

Conclusions

SMA-GPi FC is one of the key pathological circuit in Tourette syndrome.

Significance

The individual peak FC location in the left SMA potentially serve as stimulation targets for rTMS treatment of TS.

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异常的个性化功能连接：小儿抽动秽语综合征的潜在刺激目标

研究目的为了研究个体化的峰值功能连接是否有可能成为重复经颅磁刺激（rTMS）疗法的目标，我们调查了图雷特综合征患者皮层运动区与关键脑区苍白球内侧（GPi）之间峰值功能连接（FC）的位置，并探讨了疾病严重程度与这些异常功能连接之间的关系：研究对象包括 103 名确诊为妥瑞症的儿童和 66 名年龄匹配的发育正常儿童。研究以 GPi 为种子，比较了两组儿童辅助运动区（SMA）和前运动区的个体化 FC 峰值强度。研究还分析了运动区FC峰值的空间分布以及基于GPi的体素FC：结果：以左侧 GPi 为种子，图雷特综合征患儿左侧 SMA 的 FC 峰值较低。FC峰值的降低与耶鲁全球抽搐严重程度量表评分呈显著负相关：结论：SMA-GPi FC是妥瑞症的关键病理回路之一：意义：左侧SMA的单个FC峰值位置可作为经颅磁刺激治疗TS的刺激目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.