Emerging Promise of Green Synthesized Metallic Nanoparticles for the Management of Neurological Disorders.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY Current pharmaceutical design Pub Date : 2024-10-11 DOI:10.2174/0113816128337464240930042205

Zahra Esmaili Moghadam, Samin Hamidi, Maryam Azarfarin, Sara Salatin

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Abstract

The management of neurological disorders is very challenging due to the presence of the bloodbrain barrier (BBB) that prevents the entry of drugs into the central nervous system (CNS). The advancement of metallic nanoparticles (NPs) provides a novel direction for the treatment of neurological disorders. However, there is a significant concern regarding the toxic effects of metal NPs on biological tissues like the brain. The green synthesis strategy offers a superior alternative to the traditional methods for the development of metallic NPs. Notable metal and metal oxide NPs can be produced using various bio-reductants derived from natural sources such as plant tissues, fungi, bacteria, yeast, and alga. These biological agents play double roles as they expedite the reduction process and act as capping and stabilizing agents. In this paper, we discuss the major neurological disorders and the physical barriers limiting the transport of therapeutics to the CNS. Moreover, a special focus is given to the unique features of green synthesized metallic NPs for therapeutic purposes in various neurological disorders. The insights provided will guide future research toward better outcomes and facilitate the development of innovative treatments for neurological disorders.

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绿色合成金属纳米粒子治疗神经系统疾病的新前景。

由于血脑屏障（BBB）的存在阻碍了药物进入中枢神经系统（CNS），因此神经系统疾病的治疗非常具有挑战性。金属纳米粒子（NPs）的发展为治疗神经系统疾病提供了一个新的方向。然而，人们对金属 NPs 对大脑等生物组织的毒性效应非常担忧。绿色合成策略为开发金属 NPs 提供了一种优于传统方法的替代方案。利用从植物组织、真菌、细菌、酵母和藻类等天然来源提取的各种生物还原剂，可以生产出显著的金属和金属氧化物 NPs。这些生物制剂具有双重作用，既能加快还原过程，又能起到封盖和稳定剂的作用。在本文中，我们将讨论主要的神经系统疾病以及限制治疗药物向中枢神经系统运输的物理障碍。此外，我们还特别关注了绿色合成金属 NPs 在治疗各种神经系统疾病方面的独特功能。这些见解将指导未来的研究取得更好的成果，并促进神经系统疾病创新疗法的开发。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.